Authentic Biochemistry

A general audio lecture involving a molecular interactome mediating  the  innate immune response and the control over T and B lymphocyte memory cells resulting in long term potentiation of autoimmune disease during aging.

I discuss the complex  but potent interactions of TLR signaling with plasma membrane protein complexes including  semaphorin cytoplasmic kinase interactions leading to PPAR gamma transcription that fires off CD36 and beta oxidation gene transcription to switch M1 to M2 macrophage polarity thus feedback regulating the pro-inflammatory glycolytic mToRC system dynamics.

Aging is associated with a corruption in this fine-tuning that presents in the older sedentary human individual as a simple dysregulation of inflammation that ultimately impairs the ability to ward off otherwise relatively innocuous pathogens while simultaneously punctuating the equilibrium otherwise exerted  to control tissue repair and the potential for cellular proliferation and oncogenesis. 

References

Nat Immunol. 2018 Jun;19(6):561-570.

FEBS Letters 2011 Volume 585, Issue 23, Pages 3829-3835

Scientific Reports 2015 volume 5, Article number: 11789

Ann Allergy Asthma Immunol. 2000 Jul;85(1):9-18 

Macrophage polarization and differentiation works in conjunction with CD4+ T lymphocyte differentiation into Th1 and Th2 subclasses and both NK and B cell activities. The aging human loses feedback control over the pro-inflammatory and anti-inflammatory pathways from these classical cellular differentiations contributing to hyperinflammation and/or hypoinflammatory responses ultimately resulting in pathological cell degeneration or proliferation, morbidity and death. Dr. Daniel J. Guerra Authentic Biochemistry Production. 18.9.21.

Reference

Nature Immunology June 2018  19: 561–570

https://youtu.be/4sW-BNVhzrs

Dr. Guerra introduces a primer on membrane biochemistry in preparation for a florid analysis of autophagy and the various forms of programmed cell death linked to the aging human.

References

Cell Discovery volume 7, Article number: 4 (2021)

Non coding RNA may regulate melanogenesis and in combination with plasma cell producing IgG the nutritional regulation of satiety.

Aging results in alterations of this complex system thus resulting in localized melanogenesis and a corruption of the HPA axis.

References:

Aging (Albany NY). 2021 Jan 31; 13(2): 2700–2726.

Stem Cells Int. 2020; 2020: 1047896. First Published online 2020 Jul 8

PNAS. 2002 Dec 24;99(26):17155-60

Components of metabolic sequence toward gluconeogenesis in the human liver.

Dr. Guerra details the glucagon and epinephrine mediated control through Stimulatory G-protein couple adenylate cyclase activating PKA over Hepatic Glycolysis and Gluconeogenesis. 

Utilization of a protein cysteine SH derived thioester intermediate alters the free energy hurdle for the synthesis of 1,3 bis PGA thus allowing for glycolytic ATP and NADH synthesis.

The interaction of glycolysis and lactic acid transport from skeletal muscle to the liver plays a significant role in oxygen uptake, transport and release in association with pulmonary carbon dioxide efflux . Dr. Daniel J. Guerra. An Authentic Biochemistry Production 19.8.21.