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Authentic Biochemistry
Authentic Biochemistry episodes
- Lymphocyte maturation and the special Innate like Lymphocyte Subclass including Natural Killer and other ILC lineages. DJGPhD.14.10.21. Authentic Biochemistry
Front Cell Dev Biol. 2019; 7: 226
Advances in Immunology. 2011 v.109.Pp125
Cell Reports 10, 2043–2054, March 31, 2015
Experimental & Molecular Medicine volume 51, pages1–15 (2019)
30 min - Immunosenescence and Inflammaging via thymic Involution and comorbid pathophysiology of obesity and aging present a chronic inflammatory phenotype prone to morbidity. DJGPhD. Oct.04,2021. Authentic BC
Dr. Guerra details the aging immune phenotype at the transcriptional and metabolic level.
References
Immun Ageing. 2020; 17: 2.
Experimental & Molecular Medicine volume 51, Article number: 80 (2019)
Nat Immunol. 2011 Nov 6; 12(12): 10
Cell 146, 772–784, September 2, 2011
Nat Immunol. 2014 Aug; 15(8): 767–776.
Cell Reports Volume 17, Issue 11, 13 December 2016, Pages 2827-2836
30 min - Natural cytotoxicity receptors (NCR's) within group 3 innate lymphoid cells (ILC3): an association of transcription factors in IBD's and aging. DJGPhD. 03.10.21 Authentic Biochemistry.
ILC3 can contribute to the progression and aggravation of IBD's while both IL-22 and IL-17, along with IFN-γ, are overexpressed by the dysregulation of NCR− ILC3 or NCR+ ILC3 function
NCR (natural cytotoxicity receptors), are type 1 transmembrane proteins of the immunoglobulin superfamily. Upon stimulation, NCR's mediate NK killing and release of IFNγ. They bind viral ligands such as hemagglutinins, neuraminidases, bacterial ligands, and cellular ligands related with auto immune diseases, tumour growth, and associated aging morbidity.
References
Experimental & Molecular Medicine volume 51, Article number: 80 (2019)
Cell Death & Disease volume 10, Article number: 315 (2019)
Front. Immunol., 28 September 2015
30 min - Omega three fatty acids and PE N-methyl transferase are associated with methylation and acetylation patterning in NK cells via AMPK and stress.DJGPhD. 29 September 2021.
Omega-Three VLCPUFA's as asymmetrically distributed in membrane glycerolphospholipids mediate vesiculation and permeability of endothelia to circulating lymphocytes and leukocytes thus coupling folic acid, Vitamin B12 and epigenetic modification of chromatin to ultimately link bioenergetics with cytotoxicity and inflammation. This regulated system involves the neuroimmunoepigenome and the senescent environment of aging human vasculature, skeletal and cardiac muscle, and the CNS toward pathobiochemical increases in morbidity -presenting disease phenotypes.
References
J Biomed Biotechnol. 2011; 2011: 298348.
Blood 2009 114:2567-2568; https://doi.org/10.1182/blood-2009-07-230904
Am J Clin Nutr. 2017 Oct;106(4):1157-1165. doi: 10.3945/ajcn.117.155648.
BIOCHEMISTRY AND CHEMICAL BIOLOGY STRUCTURAL BIOLOGY AND MOLECULAR BIOPHYSICS
March 2018 https://elifesciences.org/articles/34394Sci Signal. 2017 Jan 31; 10(464): eaaf7478.
Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49-55. doi: 10.1016/j.plefa.2015.04.007.
Int J Biol Sci. 2015; 11(11): 1272–1280
30 min - Natural Killer Cell switching via demethylation of Histone 3 LYS may correlate with the human aging phenotypic hyper-inflammatory state. DJGPhD. 28.9.21
Pro-inflammatory gene transcription is tanked when demethylation is inhibited but cytotoxicity of virally infected or cancer cells by NK’s (where demethylation is inhibited) remains intact.
References
J. Biol. Chem. 2018;293:2422-2437
J. of Biol. Chem. 2016. 291, 23756-23768
30 min - The Genome and the Immunoepigenome interact across a three-way trigonal planar field with the Environment to Obtain the Aging Phenomena. DJGPhD.27.9.21
Dr. Guerra discusses some of the complexity of both the epigenetic mechanisms and cellular responses associated with immunomodulatory failure in the aging human.
References
Anal Cell Pathol (Amst). 2018; 2018: 787.1814.
Daniel J. Guerra. 2018. DOI: 10.5772/intechopen.82176 https://www.intechopen.com/chapters/64596
30 min - Natural Killer cells and the epigenomics of gene expression: implications for the aging -senescent human. DJGPhD. 26 .9.21. Authentic Biochemistry
Dr. Guerra continues a dialectical accounting of the biochemical and cellular events leading to the terminal outcome of aging.
Topic today is the reintroduction of Natural Killer Cells and the epigenetic mechanisms that orchestrate unique gene expression.
References
Anal Cell Pathol (Amst). 2018; 2018: 787.1814.
The Journal of Biological Chemistry2018. 293: 2422-2437
30 min - REDOX Biochemistry Primer . DJGPhD Authentic Biochemistry . 24.9.21
Oxidases, dehydrogenases and oxygenases in the electron transport chain et al.
29 min - Video Lecture Announcement. Please Listen to this audio! Grazie, Dr. Daniel J. Guerra 22.9.21
This is the link to my new (second in the series) of synoptic Human Aging YouTube lectures.
https://youtu.be/IckyMGw8Ffs
Please subscribe to both my podcast and YouTube channels!
And please contribute!
It is the First day of Autumn. Enjoy!
6 min - The Interferon I role in autoimmune disease and the corruption of mechanisms that lead to age-related morbidity and mortality.DJGPhD. 22.9.21
Interferons are innate immune agents of inflammation and recovery. Mutations or epigenetic modifications associated with advanced aging may corrupt interferon pathway fidelity involving mitophagy leading to autoimmune disease and morbidity later in life.
References
Nat Immunol. 2021 Mar; 22(3): 312–321
J Neuroinflammation. 2019; 16: 236.
31 min
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.