Authentic Biochemistry

Patho-Biochemical Pathways in CNS-Endocrine Organs with a special emphasis on sphingomyelin phosphodiesterases in the HPA axis of the CNS and Beta hemolysins as virulence factors from the human bacterial pathogen, Staphylococcus  aureus. Dr Daniel J Guerra published on 27 April 2020.

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Authentic Biochemistry Rules!

Dr Guerra delivers his third informed discussion of Membrane lipid raft biology and the role of Sphingolipids in mediating an immune response that results in massive tissue damage and poor disease outcome. Published 11 April 2020

In this audio lecture presentation, Dr Guerra gives an aggregated explanation for the association of subcellular biochemical metabolism of sphingolipids via the target of Cationic Amphipathic Drugs such as SSRI's in altering cell fate from programmed cell death to tissue preserving autophagy. Published 11 April 2020.

Dr Guerra uses the Dialectical Method via the Logical Square of Opposition combined with an analysis of the current biomedical evidence associated with the COVID 19 corona virus  to obtain validated conclusions. 23 March 2020.

In this third segment on the grounding of Natural Science and the world View it advances,  Dr Dan Guerra introduces the endojective perspective for space-time and the foundation of knowledge toward the representation of phenomena as pattern recognition from a possibilistic metaphysical landscape via freely chosen inductive reasoning in an ultimately uncertain universe. Published 20 March 2020.

In this second philosophical segment, Dr. Guerra introduces space-time as a physical manifestation of the synthetic a priori of Phenomenological Metaphysics as he draws inferences from pre-Socratic concepts of vortices and co-mingles these ideas with Clerk Maxwell's explanation of the electromagnetic theory and quantifiable resolution for the velocity of light. Published on the IDES of March 2020.

In this first segment  of a three part series, Dr Guerra  sets out to ground his scientific principles with an a priori epistemological reasoning that leads to the transcendental method for instantiating metaphysics to perform biochemical, genetic  and physiological research. Recorded 11 March 2020.  

Dr Guerra explains how  there is a cumulative balance between S1P and Ceramide will influence apoptosis and change the regulation of autophagy by the complex interplay between mTOR, beclin, and Bcl-2 where S1P-dependent autophagy is thought to be a homeostatic, pro-survival response involved in the clearance of intra-cellular debris.Describing these systems within the context of inflammation and pathobiochemistry will be obtained.

Today's podcast establishes the significance of sphingolipids in maintaining normal biochemical and physiological homeostasis by detailing membrane organization of pathways and linkage to cell fate and the potential for pathobiology in human disease. Published 03 March 2020 by Daniel J. Guerra, PhD