Authentic Biochemistry

T Lymphocyte communication with antigen presenting innate immune cells coupled with B cell activation may be regulated by a glycoprotein that links to discrete glycosylation patterns on membrane polypeptide domains

The epigenetic control over gene expression via transcriptional and post-transcriptional molecular interactions through time including interfering RNA and covalent modification of chromatin results in enivonmental, nutritional and age-related phenotypes . In this episode of Authentic Biochemistry, Dr. Guerra starts investigating  the molecular mechanisms employed.

Professor Guerra begins an arc of lectures on the molecular events that describe the covalent modification and temporal variation of gene expression collectively called epigenetics.

Prof Guerra gives a brief examination of Leptin -associated cancers. 15 October 2019

Dr Guerra discusses the intricate roles of Leptin and its receptor in various human diseases. 10 October. 2019

Dr Guerra of Authentic Biochemistry provides his  third discussion of adipokine-mediated control over obesity and associated disease from animal models to clinical disease. 02 October 2019.

Dr Dan Guerra pursues how Leptin and POMC regulate neuroendocrine and neuro-appetitive behaviours that link obesity and associated metabolic and life-style disease with the dysregulation of energy homeostasis

Dr. Guerra of Authentic Biochemistry and the VerEvMed YouTube channel provides critical in-depth neuro-anatomical and HPA axial complicity in Leptin Signaling from the Adipose to the stress- and basal regulation of human physiological responsiveness. 22 September 2019 

In this Authentic Biochemistry Podcast Episode Prof. Guerra describes the specific metabolism of very long chain polyunsaturated fatty acids from essential dietary precursors of both the Omega 6 and Omega 3 series and associates these pathways with a recent 2019 publication that provides evidence for Omega 3 fatty acid inhibition of adipose stem cell associated IL17a  proinflammatory  cytokine transcription thus inhibiting obese adipose inflammation. 08 September 2019. 

Authentic Biochemistry's Dr Daniel Guerra implements his keen understanding of lipid metabolism to uncover the network of cellular, subcellular and pathway domains  regulating fatty acid oxygenation and both glycerol-and sphingosine- lipid signaling that function to mediate cell fate and the inflammatory response in relation to dietary omega three fatty acid.   04 Sept 2019.