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Authentic Biochemistry
Authentic Biochemistry episodes
- Do Omega three fatty acids ameliorate obese adipose derived inflammation via a T cell response?
Dr. Guerra of Authentic Biochemistry discusses a current published paper that shows how DHA and EPA derived from dietary alpha linolenic acid (18:3 cis d 9,12,15) correlates with a decrease in the production of the pro-inflammatory cytokine, IL17-A in a model system composed of obese adipose stem cell populations.
28 min - Dr. Guerra finishes the Treg lectures by drawing upon on a transcription factor molecular thread of Ariadne to deliver T cell lineage architechtonics.
This is volume VI of the Tregs lecture narrative in which Dr. Guerra provides an introduction to a Diaeventontological process for navigating the labyrinth of T cell biochemistry. Published 17 August 2019. Authentic Biochemistry Podcast.
28 min - Dr Guerra reports on evidence that Treg cells are negatively controlled by Nfil3 via inhibition of FOXp3 transcription while activating Th1 and Th2
Treg and Th cells are under transcriptional modulation via cytokine mediated control of a Nfil3 protein that serves to block FOXp3 expression.DR Guerra verifies the evidence in the data from a recent paper: Experimental & Molecular Medicine volume 51, Article number: 80 (2019) that demonstrated Inhibition of the TGF-β signaling pathway led to increased Nfil3 expression which blocked Foxp3 transcription via SMAD3.
This is an important contribution to the T lymphocyte literature as it points to the proximal and distal modulation of T cell lineage differentiation, thus focusing attention to potential pharmacotherapeutic and immunoepigenetic mechanisms to control inflammation in diseases such as IBD while simultaneously suggesting strategies to reorganize the T cell profile to destroy tumors.
Dr Daniel J Guerra, Authentic Biochemistry. 17 August 2019.
28 min - Dr Guerra moves onward through the T cell lineages to an event ontology for Treg Stimulation/Activation and Stabilization IV.
Prof. Guerra provides a narrative focusing on evolutionary perspectives and the resultant lymphocyte differentiating foundations for the adaptive immune response as a means to apprehend the event-ontological diverse transcriptional mediation ultimately landing on the Treg FOXp3 promoter . Part IV
29 min - T-regulatory Transcription Factor modulation directs lineage adaptation and potency in a pro-inflammatory environment
In this Authentic Biochemistry episode Dr Guerra unfolds the complex transcription factor and membrane & nuclear- receptor repertoire associated cytokine and chemokine axis activating and maintaining Treg cell differentiation to mediate the Th pro- inflammatory response
29 min - Innate lymphoid cells and the frank T lymphocyte family as controlled by cytokinogenesis, co-stimulation, and Tregs. Part I.Dr Dan Guerra
Dr Dan Guerra presents "T regulatory Cells in Human Biology and Disease. An update on transcriptional control". Vol.I. This first segment introduces the elaborate nature of innate and acquired lymphoid cells and the transcription factors that drive lineage differentiation.
29 min - Prolegomena to T regulatory cell transcriptional control mechanisms and a request to subscribe from Dr. Guerra
This is a brief introduction to what will be a multi-segmented sequence of podcasts on the complexity of T cell mediated immunity and its native regulation via Treg activation.
8 min - The fate of the mammalian CNS is a matter of lipid sponsored program cell death
In this podcast, Authentic Biochemistry's own Dr. Dan Guerra ties the actuated Moebius strip of anti-apoptosis rendered neuronal differentiation amidst a tempest of ceramide synthetic possibility.
29 min - Dr. Guerra provides a clinical discussion of HCC pathogenesis and treatment including the role of HCV. 03 July 2019
Dr Guerra of Authentic Biochemistry navigates through the protease inhibitor literature and starts a journey into hepatitis C virus (HCV)-mediated HCC induction and some of the pharmacotherapies impacting this axis.
29 min - SERPIN mediates transcriptional control over pro-tumorigenic pathways including a phosphatidyl inositol 1,3 kinase delta mediated mechanism.
Dr. Guerra focuses on emerging signaling and immunoepigenetic variations around the theme of protease inhibitor mediation of various stages and forms of solid organ and metastatic tumorigenesis in this June 29,2019 installment of Authentic Biochemistry.
29 min
About Authentic Biochemistry
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.