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Authentic Biochemistry
Authentic Biochemistry episodes
- Dr Guerra admits Serpin mediated cancer ablation is multivalent and pharmaceutically treacherous
Dr Dan Guerra reveals that serine protease inhibitors (Serpins) are endogenous proteins that block protease-mediated metastasis and cancer associated fibroblast activation in some tumor microenvironments but not all. The myriad 'labyrinth' interactions among cytokines , proteases, protease inhibitors and the dysregulation of the T-lymphocytic immune response obtains a confounding pharmacotherapeutic anisotropy.
30 min - Introduction to Proteases and Protease Inhibitors as Prolegomena to Specific HCC pathophysiology
Dr.Guerra of Authentic Biochemistry provides a primer on polypeptide proteases and their mode of action as well as their control via processing and inhibition in clinical medicine
30 min - HCC Episode VII. Dr Guerra tackles the pathogenecity of the serine proteinase inhibitor paradigm . 08 JUne 2019
Serine proteinases and their peptide inhibitors, the SERPINS, have a role to play in liver pathology and disease potentiation leading to subcellular protein aggregation, enhanced inflammation and ultimate hepatocellular carcinoma. Dr. Guerra of Authentic Biochemistry introduces this new plank in the knowledge platform being constructed to apprehend either the necessary or sufficient conditions in HCC.
29 min - Hepatocellular Carcinoma Pathobiochemistry Chapter/Lecture V from Dr. Daniel J. Guerra. Authentic Biochemistry.28 May 2019.
In this segment I provide more discussion of the published evidence linking glycolytic pathway enzymes to HCC progression. The expression of certain interfering RNA's that differentially regulate gene expression and promoter habilitation can lead to cyclin dependent kinase mediated chromatin remodeling enhancing cell -specific expression of enzyme isoforms that promote rather than defeat disease progression.
29 min - Dr Guerra Characterizes How Glycolytic Enzymes Proxy Oncogenically in Prodromal Hepatocellular Carcinoma. 26 May 2019
Dr. Guerra of Authentic Biochemistry continues with the 4th in a series of HCC lectures from the primary research literature by explaining the interacting roles of pyruvate kinase M2 and phosphofructokinase 2 promote aerobic glycolysis-enhancing cancer progression.
29 min - Dr Guerra introduces the pseudo-paradoxical irony of Pyruvate kinase M2 expression toward the biochemical Aetiology of HCC
Authentic Biochemistry's host, Dr Dan Guerra, continues his in depth cellular and molecular discussion of hepatocellular carcinoma (HCC) by introducing the non-universal yet a priori role for the glycolytic enzyme pyruvate kinase isoform M2 in paradigmatic tumor associated aerobic glycolysis.
29 min - Authentic Biochemistry Podcast. Dr. Dan Guerra presents Heptaocellular Carcinoma Part II: Metabolic and Signal Transduction Cascades
Dr Guerra takes a deeper dive into the hormonal and subcellular dysfunctional arrays linking obesity to Non-alcoholic Steatohepatitis (NASH) and Hepatocellular Carcinoma
29 min - Dr Guerra Starts his podcast lecture sequence on Obesity and Hepatocellular Carcinoma. Series session#1
This is Part One of what will be a 3-5 part sequence of podcast lectures giving Authentic Biochemical discussion concerning the links between obesity , sedentary lifestyle, alcohol consumption and inflammatory diseases of the liver that may lead to the high mortality cancer, Hepatocellular Carcinoma.
29 min - HDAC 4 is a positive player in ALS muscle since it is not a functional histone deacetylase: The complexity of motor neuron disease reveals not-so-subtle differences in protein function
Because HDAC4 closely resembles the structural component of the superfamily of histone deacetylases, in might be assumed it functions to catalyze the removal of LYS bound acetate. But since HDAC4 does not contain the catalytically necessary TYR-OH but rather an HIS-imidizole it has no deacetylase enzymatic activity. However HDAC4 does interact with other proteins and the net result is protective of skeletal muscle atrophy and motor neuron degeneration in a murine mutant human SOD1 model of Amyotrophic Lateral Sclerosis (ALS). This Authentic Biochemistry podcast episode reveals once again that specificity in time and space with coordinated expression of biochemical species will be more complicated than previously reported once a sharper lens is used to examine the disease pathology at the biochemical/molecular level.
28 min - Dr Guerra continues : Glutamate induced ferroptosis involves lipid peroxidation and ceramide production leading to an inflammatory response in neurodegeneration
Dr Daniel Guerra or VerEvMed and AB podcast provides the second part of his discussion concerning excitotoxic glutamate inducing aSMASE mediated neurodegeneration involving iron and the depletion of the glutathione-ROS- scavenging system in damaged and diseased oligodendrocytes. 25March2019B
30 min
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.