Authentic Biochemistry

By Dr Daniel J. Guerra

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FAQs about Authentic Biochemistry:

How many episodes does Authentic Biochemistry have?

The podcast currently has 1,182 episodes available.

Authentic Biochemistry episodes:

May 16, 2023 ImmunoEpigenetics 66. The NOX/PHOX/DUOX enzymes in atherosclerosis, thyroid hormonogenesis and thyroid tumorigenesis. An epigenetic telos from oxidized lipid to altered transcription patterns.DJGPhD.
References
PLoS ONE 2012. 7(4): e3440
Steroids 2021. Volume 172, August, 108854
Antioxidants 2019, 8(5), 126
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30min
May 14, 2023 ImmunoEpigenetics65. 7-keto-cholesterol-induced miR-144 transcription inhibits IDH2 translation lowering NADPH required for NO synthesis to maintain endothelial function leading to atherosclerosis.
References
Free Radical Biology and Medicine
Volume 71, June. Pages 1-15
Cardiovasc.Res. 2012 May 1; 94(2): 379–390.
Int. J. Mol. Sci. 2020, 21(7), 2578; https://doi.org/10.3390/ijms21072578
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30min
May 13, 2023 ImmunoEpigenetics65A. Micro-RNA mediated cancellation of mitochondrial NADPH-producing Isocitrate Dehydrogenase 2is controlled by 7-Keto cholesterol. DJGPhD 12May2023. Authentic Biochemistry Podcast
References
Free Radical Biology and Medicine
Volume 71, Pages 1-15
Steroids. 2021 Aug; 172:108854.

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16min
May 12, 2023 ImmunoEpigenetics64. IDH1/2 ad Malic enzymes 1/2/3 may generate NADPH thus driving removal of ROS while simultaneously promoting atherosclerosis and tumorigenesis via epigenetic and bioenergetic means
References
Free Radical Biology and Medicine 2014. Volume 71, June.Pages 1-15
J Mol Endocrinol. 2020 Nov; 65(4): R77–R90.
REDOX and Cholesterol metabolism lectures-Dr Guerra

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30min
May 10, 2023 ImmunoEpigenetics63. Amino acid metabolism is linked to DNA methylation via glycolytic intermediates and redox poise to expose neomorphic /antimorphic IDH1/2 transformation generating oncometabolites
References
Cancers (Basel). 2019 May; 11(5): 678.
Oncogene.2017 Mar 23; 36(12): 1607–1618
Dr Guerra's annotated lecture notes from graduate biochemistry course(s)
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30min
May 10, 2023 ImmunoEpigenetics62.Macrophage "training" and T cell activation are epigentically controlled by moonlighting glycolytic and amino acid metabolic enzymes generating enantiomers of 2-OH glutarate.DJGPhD
References
Front. Cell Dev. Biol., 26 March2021 Sec. Molecular and Cellular Oncology Volume 9
Cancer Drug Resist 2020;3:762-74.
Oncogene.2017 Mar 23; 36(12): 1607–1618
Front Immunol. 2020; 11: 1782.
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30min
May 09, 2023 ImmunoEpigenetics61. The role of leucocyte and lymphocyte aerobic glycolysis and bioenergetic trafficking between cytosol and the mitochondria mediating nuclear epigenetic substrate availability.
References
Dr Guerra Intermediary metabolic lecture notes-graduate biochemistry lecture archives
Epigenetics. 2019; 14(12): 1183–1193.
Drug Discov Today. 2017 Jan; 22(1): 186–193.
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30min
May 07, 2023 Immunoepigenetics 60. LOH of PHLDA3 confers wt allelic methylation and loss of activity in pancreatic neuroendocrine tumorigenesis. DJGPhD.7May23 Authentic Biochemistry Podcast
References
Int J Mol Sci. 2020 Jun; 21(11): 4098.

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30min
May 06, 2023 ImmunoEpigenetics59. The P53/AKT/PHLDA3 axis over tumorigenicity is controlled by endomembraneous targeting via glycerol lipid PhosphatidylInositol bis-phosphate (PIP2) phosphorylation to PIP3.5.12.23
References
Int J Mol Sci. 2020 Jun; 21(11): 4098.
Authentic Biochemistry lectures :ImmunoEpigenetics 56-58

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30min
April 28, 2023 ImmunoEpigenetics 58. Epigenetic mechanisms role in Loss of Heterozygosity (LOH) in TSG's advancing targeting of solid tumors via pharmacotherapeutic CAR-T cells. DJGPhD 27.4.23. Authentic Biochem.
References
BMC Medical Genomics. 2015. volume 8, Article number 45.
Journal for ImmunoTherapy of Cancer 2022;10:e003826.

...more
30min

FAQs about Authentic Biochemistry:

How many episodes does Authentic Biochemistry have?

The podcast currently has 1,182 episodes available.