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Authentic Biochemistry
Authentic Biochemistry episodes
- BioMed Portrait VIII. c.16. Coordinated complimentarity of cell cycle MEK kinase cascade with the IL33-ST2 and CysLT1R mediatedILC2 activation to promote type 2 immunopathology. DJGPhD.25.1.24
References
J Immunol. 2018 Feb 1; 200(3): 915–927
Cells. 2020 Jan; 9(1): 198.
Cells. 2022 Apr; 11(7): 1105
Nature Comm. 2020. volume 11, Article number: 35
Schubert F. 1829. Fantasie in F minor. D940
https://youtu.be/UyjzqPPXDcw?si=XW_SMP7j-Kza8pmq
Winwood, Capaldi and Wood. 1967 (Traffic). "Dear Mr Fantasy"
https://youtu.be/dyMiUmrouZU?si=1ZSdXupm3WFBAxTz
30 min - BioMedical Portrait VIII.c.15. ILC associated hippocampal RNA-BP's exacerbate GLU neurotoxicity and regulate CysLT1R in lung ILC2's. DJGPhD. 23.1.24.
References
Nat Commun. 2022; 13: 4435.
Nat Commun 2020; 11: 35
Hayward, J. 1971. "You Can Never Go Home" Moody Blues.
https://youtu.be/mUhboF8d1x0?si=IX4iP_W0f3uR65qo
Jagger, Richards, Oldham. 1964. "As Tears Go By". Marianne Faithful.
https://youtu.be/S8EykQaZ8CU?si=X42TiNsveR7rwdHB
30 min - BioMedical Portrait VIII.c.14 The dialectical events between immune responses and leukotriene signaling are modulated by tissue-resident and circulating cell patterns via RNA binding proteins.DJGPhD.
References
Nat Commun. 2022; 13: 4435.
Virchows Archiv: European Journal of Pathology, 2020. Vol. 476, Issue 2
Cell Death Differ. 2015 Apr; 22(5): 703–718
Pentangle.1971. Hunting Song.
https://youtu.be/CwvpMGc_J-w?si=s6pS2agc5s1N0H2z
Falconieri , Cima, Uccellini, Turini, Merula, et al. 1600-1650. Early Italian Baroque Ensemble.
https://music.youtube.com/playlist?list=OLAK5uy_mQznM05seareQTK-s3j-1VgS4DHblD5po&si=3mJts6TW3-T2g7k5
30 min - BioMedical PortraitVIII.c.13 Leukotriene metabolism and reception is linked to innate like lymphocytes involved in airway inflammation and hyper-responsiveness-associated asthma.DJGPhD.19.1.24.AB.
References
J Immunol. 2009 Feb 1; 182(3): 1641–1647.
Cell Reports 2015 10, 2043-2054DOIVirchows Archiv:European Journal of Pathology. 2020. 09456317, Vol. 476, Issue 2
Poe, EA. 1845. "the Raven" https://youtu.be/wAdQ3CcPHQU?si=2qpStYF2gdUJ4f35
Buddy Morrow and his Orchestra. 1960. "the Black Cat"
https://youtu.be/9w_VL7oq-mE?si=XiorgTkvSGzJ4BK0
30 min - BioMedical Portrait VIII.c.12. 5-LOX associates with FLAP and PLA2 at the nuclear envelope to trigger and control ILC2 mediation of the allergic asthma AHR pathology. DJGPhD 17.1.24. Authentic Bioch.
References
Immunology. 2019 Apr; 156(4): 402–412.
J Immunol. 2017 Aug 1; 199(3): 1096–1104
Front. Immunol., 06 June 2019
Mol Biol Cell. 2012 Nov 15; 23(22):4456–4464.
Virchows Archiv: European Journal of Pathology, 09456317, Feb2020, Vol. 476, Issue 2
Pavana, Gagliarda, Ciaccona, Passacaglia 1535-1615.
https://youtu.be/AY533zpCw74?si=224HuGs438aPHrrd
30 min - BioMedical Portrait VIII. C.11 Peptidyl leukotrieneR- mediated transcription of PTGS2and LOX15B with IL4/IL13 and IL33 in asthmatic lung airway constrictionin MDM's LM's and ILC2's DJGPhD.16.1.24
References
Immunol.2017 Aug 1; 199(3): 1096–1104.
British J of Pharmacology. 2015. Volume172, Issue17: 4319-4330
Beethoven, L. 1826. String Quartet Op. 135 in F Major (#16)
https://youtu.be/1hxpIQ3XhXA?si=65eTt7TlOZYCNsG8
30 min - BioMedical Portrait VIII. c.10. The LOX5 and LOX12/15 pathways for 20:4, 20:5 and 22:6produce over 50 unique molecular species of oxylipins and lipoxins with unique biological sequalae.DJGPhD.14.1.24.
References
Int.J. Mol. Sci. 2022, 23(23), 14883.
Prostaglandins Other Lipid Mediators. 2023 Jun:166:106726.
British J of Pharmacology. 2015. Volume172, Issue17. 4319-4330
Mozart, WA. 1791. Requiem.D Minor, K. 626
https://music.youtube.com/watch?v=RDegrbjfiWU&si=x-SSYDxEOv5Vc4xE
Miller, S. 1977. Wintertime.
https://youtu.be/HUv7pXgZ9NA?si=JzaZOWKLkPEMiyKj
30 min - BioMedical Portrait VIII. c.9. Initial detail of the LOX vs.COX isoform utilization of essential and other dietary PUFA's in complex leukotriene biosynthesis. DJGPhD.11Jan24.Authentic Biochemistry.
References
British J of Pharmacology 2015. Volume172, Issue17September
Pages 4319-4330Prostaglandins Other Lipid Mediators. 2023 Jun:166:106726.
1718. Concerto No. 4 in F minor, Op. 8, RV 297, "Winter" (L'inverno)30 min - BioMedical Portrait vIII. Leukotrienes. c.8 Leukotriene regulated Heterodimer Nuclear Receptor transcription factors organize around complex multi-ligand binding and sojourner molecular modifiers
References
British J of Pharmacology 2015. Volume172, Issue17 September
Pages 4319-4330Chem Rev. 2011 Oct 12; 111(10): 6321–6340
JBiol Chem. 2020 Jul 17; 295(29): 10045–10061
Mozart, WA. 1768. January. Symphony #7 in D major K.45.composed in Vienna just 10 days before he turned 12 years old.https://youtu.be/ABOle_eSq9c?si=GcA8EvXbpEZP0W0A
29 min - BioMedical Portrait VIII.c.7. Differential control over fatty acid oxygenation and PPAR/RXR heterodimer pairing in mammalian uterine cell estrus physiology.DJGPhD.8Jan2024
References
General and Comparative Endocrinology,2018-06-01, Volume 262, Pages 27-35
Pisendel JG 1735.Violin Concerto in D major, JunP I.5.
https://youtu.be/dvwhXXvFiNg?si=YfS2waKLC5WHy0En
30 min
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.