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Authentic Biochemistry
Authentic Biochemistry episodes
- BioiMedical Portrait III. NLRP3 Inflammasome and senescence-associated heterochromatic foci in macrophages, Kuppfer Cells and Liver sinusoidal endothelial cells contibute to liver/adipose disease
References
Telemann Georg P. 1765. Overture D Major, TWV 55:D18 | Tafelmusik https://youtu.be/8r-IFLtN9x4?si=T2hp65oGT--dTivY
Leukemia 2020 volume 34, pages 75–86
Nat Cell Biol. 2019 Mar; 21(3): 397–407
30 min - BioMedical Portrait III.c12. Senescent cells from aging and obesity obtain chronic hyperinflammation of adipose associated leucocyte infiltrates potentiating alternating systemic proliferation or PCD.
References
Haydn, Michael. 1760. Salve Regina in G MH32. https://youtu.be/u_Xjo5KJ3mg?si=kmKaaBJMvUgs_blX
Leukemia 2020. volume 34, pages 75–86
CELL 2006. Volume 126, Issue 3, Pages 503-514
Nat Cell Biol. 2019 Mar; 21(3): 397–407.
Curr Opin Pharmacol. 2021 Apr; 57: 107–116.
30 min - BioMedical Portrait III. AMPK regulation of ACC2 blocks MalCoA inhibition of CPTI allowing for fatty acid beta oxidation thus alleviating adipose obesity-induced macrophage pro-inflammation.DJGPhD.
References
Saint-Saens. C. 1886. Symphony 3 (avec orgue) OP.78
J Clin Invest. 2011 Dec 1; 121(12):4903–4915
Cell Metab. 2022 Dec 6; 34(12): 2036–2046.e8.
30 min - BioMedical Portrait III. c10. Ribosomal collision frequency is attenuated by ZAK and GCN2 via mutually exclusive signalling events, DJGPhD. 25.9.23. Authentic Biochemistry Podcast
References
Cell. 2020 Jul 23; 182(2):404–416.e14.
Curr Genet. 2021 Feb; 67(1): 19–26.
RNA Biol. 2023; 20(1): 737–749. published online 13sept23
30 min - BioMedical Portrait III. c9. Amino acid deprivation-linked fall of polypeptide synthetic fidelity triggers downstream ribosomal stress response phenomena including kinase mediated cell fate sequalae.
References
Cell. 2020 Jul 23; 182(2):404–416.e14.
Nature Communications 2020. volume 11,3146
Curr Genet. 2021 Feb; 67(1):19–26
30 min - BioMedical Portrait III. c8. Unique mRNA upstream open reading frames direct both the integrated stress response and rare selective up-regulation of stress-correcting protein synthesis.DJGPhD.21.9.23
References
Dr Guerra's lectures
RNA Biol. 2023; 20(1): 737–749
30 min - BioMedical Portrait III.c.7 Elementary polypeptide synthesis-translation. Lecture 1. DJGPhD.20.9.23.Authentic Biochemistry Podcast.
Reference
Dr Guerra's lecture notes
30 min - BioMedical Portrait III. c6. Adipokine and the succinate receptor systems in obese adipose inflammation as regulated by AMPK.DJGPhD.19.9.23. Authentic Biochemistry Podcast
References
Cream 1968 Wheels of Fire
J Neuroinflammation. 2019; 16: 34.
Front Immunol. 2019; 10: 345.
Cell Metabolism 2023. Volume 35 Issue 4. 601-619.e10
Sci Signal. 2017 Jan 31; 10(464):eaaf7478
30 min - BioMedical Portrait III.c.5. Adipokine mediated adipose inflamation is linked to the hypothalamic control over metabolism and systemic inflammation.DJGPhD.18.9.23.Authentic Biochemistry Podcast
References
Prostaglandins Leukot Essent Fatty Acids. 2015 Jul;98:49-55
Int J Biol Sci. 2015; 11(11):1272–1280
Front. Physiol., 01 June 2018
Int. J. Mol. Sci. 2019, 20(6), 1505
Front Immunol. 2023; 14: 1149366
30 min - BioMedical Portrait III. c.4. Adipose tissue macrophages express galectin binding proteins which alter immunosuppression and polarization;adipokines mediate the inflammatory response. DJGPhD.17.9.23
References
Luigi Boccherini: Symphony Op. 12 No. 4 in D Minor
JCI Insight. 2016 Nov 17; 1(19): e87748
Front Immunol. 2023; 14: 1149366
Adv Biol Regul.2019 Jan;71:41-54.
Int. J. Mol. Sci. 2019, 20(6), 1505
30 min
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.