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Authentic Biochemistry
Authentic Biochemistry episodes
- ImmunoEpigenetics87. Competitive inhibition of HMGCoA-R may enhance apoptosis while blocking cholesterologenesis and GGPP covalent modification of signaling kinases to thwart ETP-All in cell culture.
References
JBC.2002. Volume 277, ISSUE 2, P1128-1138.
Cancer Discov. 2022 Mar 1; 12(3): 856–871.
Guerra lectures-lipid metabolic regulation
Guerra lectures-pharmacodynamics and kinetics
30 min - ImmunoEpigenetics86. Could regimented titrating statin pharmacotherapy be useful in controlling early T lymphoid progenitor cell ETP-ALL via an epigenetic mechansim? DJGPhD.27.6.23. Authentic Biochem
Reference
Cancer Discov. 2022 Mar 1; 12(3): 856–871.
29 min - ImmunoEpigenetics85.Epigenetic plasticity-induced chromatin retailoring involving the mevalonic acid -prenyl lipid pathway promotes Early T-cell Precursor Acute Lymphoblastic Leukemia. DJGPhD.24.6.23
References
Cancer Discov. 2022 Mar 1; 12(3): 856–871.
Sci Signal. 2015 Mar 31;8(370):re4
29 min - ImmunoEpigenetics84. T cell and ILC transcription factor and cytokine signaling coordination to accelerate a combined innate/acquired immune response requires discrete epigenetic programming. DJGPhD.
References
J Exp Med. 2017 Jul 3;214(7):1861-1876
Immunol Rev. 2014 Sep;261(1):62-83
Int J Mol Sci. 2022 Mar; 23(5): 2878.
Immunity 2022. Volume 55, Issue 8. :1402-1413.e4
30 min - ImmunoEpigenetics 83. Epistemic and metaphysical considerations of immune cell epigenetic reprogramming obtaining biochemical event ontologies. DJGPhD.23.6.23. Authentic Biochemistry Podcast
References
Guerra: logical propositions and dialectical syntheses
Annual Review of Immunology2021. Volume 39: 279-311
30 min - ImmunoEpigenetics82.Innate lymphoid progenitor antibody-directed single cell DNAse hypersenitive site analysis of transcription factor specific histone methylation and acetylation modifications.DJGPhD
References
Nat Protoc. 2017 Nov;12(11):2342-2354
Annual Review of Immunology 2021. Volume 39. pp 279-311
Immunity 2022. Volume 55, Issue 8. Pages 1402-1413.e4
30 min - ImmunoEpigenetics 81.Innate lymphoid cells lack antigen receptors and are differentiated into multiple linneages via epigenetic priming of nucleosomal regions proximal to cell-specific TF's.DJGPhD.
References
Immunity 2022. 55, Issue 8. Pages 1402-1413.
Methods Mol Biol. 2018;1675:167-181.
Experimental & Molecular Medicine 2019. volume 51, Article number: 80.
Cell Reports 2015 10, 2043-2054DOI: (10.1016/j.celrep.2015.02.057)
30 min - ImmunoEpigenetics80.T lymphocyte biochemical communications are triggered epigentically and via membrane lipid molecular species recombination: A dialectical event ontological view. DJGPhD.17.6.23
Reference
Authentic Biochemistry Lecture synthesis
30 min - ImmunoEpigenetics79. T lymphocyte DPPA induced HSP27 deoligomerization-activating DGK-a associated anergy is linked to cancer cell proliferation phenotypes. DJGPhD.16.6.23b Authentic Biochemistry
Reference
J BiolChem. 2023 Mar; 299(3): 103019.
30 min - ImmunoEpigenetics 78. Classical ergodic forward deterministics do not explain biological systems; biochemical phenomena are tuned for uncertain events. DJGPhD.16.6.23. Authentic Biochemistry Podcast
References
J Biol Chem 2017 292: 20481.
Critique if Pure Reason.1781. Kant,I.
Guerra,2023. manuscripts in preparation
30 min
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.