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Authentic Biochemistry
Authentic Biochemistry episodes
- ImmunoEpigenetics97.Bcell maturation involves a multilevel epigenetic mark-up of differentiating pathways to subsequently respond to T cell activation upon 2nd signal stimulation. DJGPhD.24.7.23
References
Cellular & Molecular Immunology. 2022. volume 19, pages 1215–1234.
Front. Cell Dev. Biol. 2022. 07 January Sec. Epigenomics and Epigenetics # 805195
30 min - ImmunoEpigenetics96. APC-agMHCII and Bcell:Tcell synapse interactions yield subsequent plasma cell antibody production under the H3K4me3 epigenetic alteration of chromatin accessibility.DJGPhD.23.7.23
References
J Immunol. 2014 Aug 15; 193(4): 1531–1537
Immunology lecture notes-Guerra
30 min - Mountain Pass Adventure I. The "five best" and an excursion into asymmetry. Dr. Daniel J. Guerra. 22.7.23. Authentic Biochemistry Podcast.
Inspirations
A hot summer day and what passes as a ponder on the asymmetric.
30 min - ImmunoEpigenetics 95. Does H3K4 trimethylation play a quantitative or qualitative role in nascent activation of neonatal naive T cells toward a specific polarity of gene expression?DJGPhD.20.7.23
Reference
Immunol Cell Biol. 2022 Aug; 100(7):562–579.
30 min - ImmunoEpigenetics. 94. Neonate TCR stimulation and subsequent signaling circumventing TCR specificity differ from adult activation and cytokine expression. DJGPhD. 19.7.23. Authentic Biochemistry
Reference
Immunol Cell Biol. 2022 Aug; 100(7):562–579.
29 min - ImmunoEpigenetics 93. tTREG's not only control Th differentiation and proliferation but in an HLA-antigen mediated specificity thus differentiating CD4+ vs CD8+ inflammation as directed by 6mA.
References
Signal Transduction and Targeted Therapy 2021.volume 6, Article number: 412.
Nature Immunology. 2022. volume 23, pages 1208–1221.
30 min - ImmunoEpigenetics 92. thymic Treg populations alter Th1 differentiation. Antigen presenting DC's coordinate TCR with associated membrane proteins to support activation via PM lipid sequence.DJGPhD.
References
J Biol Chem. 2021 Jul;297(1):100900
Immunol Rev. 2014 May; 259(1):88–102.
30 min - ImmunoEpigenetics91. WTAP conditional deletion via LoxPCre controlled by FoxP3 obtains a Treg phenotype incapable of supressing murine spontaneous colitis. DJGPhD. 15.7.23. Authentic Biochemistry.
Reference
Nature Immunology 2022. volume 23, pages 1208–1221.
30 min - ImmunoEpigenetics90. Tcell receptor organization activation and adaptor protein ligand molecular signaling is regulated down stream by 6methyl mRNA speciation.DJGPhD.7July2023.Authentic Biochemistry
References
Nature Immunology 2022. volume 23, pages 1208–1221
Signal Transduction and Targeted Therapy 2021. volume 6, Article number: 412.
30 min - Enzyme Kinetics sensu strictu. The Michaelis Menten equations and precison of the kcat. DJGPhD.9July23b. Authentic Biochemistry Podcast.
References
Guerra lectures archives
30 min
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.