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Authentic Biochemistry
Authentic Biochemistry episodes
- Membrane Biochemistry 67. VDAC oligimerization inhibition can block mitochondria-mediated apoptosis and NLRP3 inflammasome activation. DJGPhD.22.10.22.Authentic Biochemistry.
References
Immunity 2022 551370-1385.e8DOI: (10.1016/j.immuni.2022.06.007
J Biol Chem. 2016 Nov 25; 291(48): 24986–25003.
J of Visualized Experiments. 2013; (81): 50966
30 min - Membrane Biochemistry 66. Staph aureus infection, autoimmune disease, biliary cholangitis, and neurodegeneration involve NLRP3 Inflammasome activation with core bioenergetic involvement. DJGPhD.
References
Dr Guerra's immunology lecture notes
J Vis Exp. 2013; (81): 50966
Front Immunol. 2019; 10: 1309.
Infect Immun. 2013 Dec; 81(12): 4478–4489.
Immunity 2022. Volume 55 Issue 8 Pages 1370-1385.e8
30 min - Membrane Biochemistry 65. The integration of pro-inflammatory signaling from a plenum of molecular membranous events: The NRLP3 Inflammsome. DJGPhD. 19.10.22. Authentic Biochemistry.
References
Dr Guerra's Immunology lectures
Am J Gastroenterol. 2004 Nov;99(11):2147-9.
Front Immunol. 2019 Jun 7;10:1309
Nat Rev Gastroenterol Hepatol. 2019 Dec 9
Immunity Volume 55 Issue 8 Pages 1370-1385.e8 (August 2022) DOI: 10.1016/j.immuni.2022.06.007
30 min - Membrane Biochemistry 64. Prelude to Biochemical Metaphysics and the Mitochondrial Membrane Damage Response I. Dr. Daniel J. Guerra.18.10.22.Authentic Biochemistry Podcast
References
Dr. Guerra's lecture notes
Immunity 2022. Volume 55 Issue 8 Pages 1370-1385.e8.
30 min - Membrane Biochemistry 63. The TCR:APC Chemokine receptor Trigger for Cytokine Stimulation. DJGPhD. 16 Oct 2022 Authentic Biochemistry Podcast
References
Dr Guerra's membrane immune synapse lectures
Al-Aghbar, M.A., Jainarayanan, A.K., Dustin, M.L. et al. The interplay between membrane topology and mechanical forces in regulating T cell receptor activity. CommunBiol 5, 40 (2022). https://doi.org/10.1038/s42003-021-02995-1
Dinkel BA, Kremer KN, Rollins MR, Medlyn MJ, Hedin KE. GRK2 mediates TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation that drives PI3Kγ/PREX1 signaling and T cell cytokine secretion.
J Biol Chem. 2018 Sep 7;293(36):14022-14039. doi: 10.1074/jbc.RA118.003097. Epub 2018 Jul 17. PMID: 30018141;30 min - Membrane Biochemistry 62. The T cell receptor mechanism II. Dr. Daniel J. Guerra. 14.10.22 Authentic Biochemistry
Al-Aghbar, M.A., Jainarayanan, A.K., Dustin, M.L. et al. The interplay between membrane topology and mechanical forces in regulating T cell receptor activity. CommunBiol 5, 40 (2022). https://doi.org/10.1038/s42003-021-02995-1
Dr Guerra Membrane lipid lectures
30 min - Membrane Biochemistry 61. The Tcell membrane :APC synapse I. Dr Daniel J. Guerra 13.10.22 Authentic Biochemistry
References
Al-Aghbar, M.A., Jainarayanan, A.K., Dustin, M.L. et al. The interplay between membrane topology and mechanical forces in regulating T cell receptor activity. CommunBiol 5, 40 (2022). https://doi.org/10.1038/s42003-021-02995-1
Seminars in Immunology Volume 13, Issue 2, April 2001, Pages 129-138
30 min - Membrane Biochemistry 60. Human neocortical membrane lipid evolution and the links to cognition,fasting, and neurodegeneration. Dr Daniel J. Guerra. 03Oct2022.Authentic Biochemistry.
References
Dr Guerra's membrane lipid lectures
Neuron 2015. Volume 85, Issue 4.Pages 695–702
30 min - Membrane Biochemistry 59. Back to the Basics.Dr Daniel J. Guerra 30 September 2022.Authentic Biochemistry
Referewnce
Guerra basics lecture
30 min - Membrane Biochemistry 58. Cardiolipin biosynthesis involves a PC-linoleic acid requiring maturase and a unique phosphatidylglycerol phosphate phosphatase. DJGPhD.25.9.22.Authentic Biochemistry
References
Dr Guerra membrane lectures
Cell Metab. 2020 Dec 1;32(6):981-995.e7
PNAS 2011.108 (29) 11860-11865
J. Dev. Biol. 2020, 8(2), 10.
Chem & Phys of Lipids.2000. June. 106:1-29
30 min
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You have wisely landed upon Authentic Biochemistry, with Dr. Daniel J Guerra, where published biochemical, physiological, genetic and immunological research along with biomedical and pharmaceutical science are interrogated.