Thermo Fisher Scientific, a world leader in biotechnology, has built a new polymerase chain reaction (PCR) system for DNA sequencing. Designed for low- to midlevel throughput laboratories that conduct real time PCR experiments, the system runs on individual QuantStudio devices. These devices are connected to Thermo Fishers cloud computing platform, which is built on AWS using Amazon EC2, Amazon DynamoDB, and Amazon S3. With this single platform, applied and clinical researchers can learn, analyze, share, collaborate, and obtain support. Researchers worldwide can now collaborate online in real time and access their data wherever and whenever necessary. Laboratories can also share experimental conditions and results with their partners while providing a uniform experience for every user and helping to minimize training and errors. The net result is increased collaboration, faster time to market, fewer errors, and lower cost. We have architected a solution that uses Amazon EMR, DynamoDB, Amazon Elasticache, and S3. In this presentation, we share our architecture, lessons learned, best design patterns for NoSQL, strategies for leveraging EMR with DynamoDB, and a flexible solution that our scientist use. We also share our next step in architecture evolution.