An intro to the "spirit molecule" and "the toad" plus safety and ethical considerations around their use

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References:

“Ayahuasca and 5 Me-ODMT.” UC Berkeley Center for the Science of Psychedelics. Last accessed 28 Sept 2023. https://psychedelics.berkeley.edu/substance/ayahuasca/

Bernal A, et al. Reactivations after 5-methoxy-N,N-dimethyltryptamine use in naturalistic settings: an initial exploratory analysis of the phenomenon’s predictors and its emotional valence. Frontiers in Psychiatry. 2022; 13: 1049643

Halberstadt A. Dimethyltryptamine: Possible Endogenous Ligand of the Sigma-1 Receptor. MAPS bulletin: Spring 2011 volume 21, number 1. https://maps.org/wp-content/uploads/2021/08/v21n1-56to58-1.pdf

Niznansky L, et al. Ayahuasca as a Decoction Applied to Human: Analytical Methods, Pharmacology, and Potential Toxic Effects. Journal of Clinical Medicine. 2022; 11(4): 1147. https://www.mdpi.com/2077-0383/11/4/1147

Paredes R. DMT vs Ayahuasca: is one better than the other? Mind Better. 17 Aug 2022. https://mindbetter.com/dmt-vs-ayahuasca/

Reckweg J, et al. A phase 1/2 trial to assess safety and efficacy of a vaporized 5-methoxy N,N-dimethyltryptamine formulation (GH001) in patients with treatment resistant depression. Frontiers in Psychiatry. 2023; 14: 1133414. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10319409/

Smith, Patrick. Ayahuasca vs DMT. Third Wave. 30 April 2023 (accessed 28 Sept 2023). https://thethirdwave.co/ayahuasca-vs-dmt/

Thomas, SS. Ayahuasa vs DMT: Unveiling the Differences and Similarities. Psychable. 23 April 2021. https://psychable.com/ayahuasca/ayahuasca-vs-dmt-whats-the-difference