Wade Davis and RFK Jr discuss The Amazon River Basin and Ayahuasca, a psychoactive brew used both socially and as spiritual medicine among the indigenous peoples of the region.  Haiti and the Caribbean are also discussed in this episode.

Wade Davis is an ethnobotanist. Davis came to prominence with his 1985 best-selling book The Serpent and the Rainbow about the zombies of Haiti. His photographs have appeared in some 20 books and more than 80 magazines, journals, and newspapers, including National Geographic. 

Davis and Kennedy are featured in the MacGillivray Freeman IMAX film Grand Canyon Adventure: River at Risk, released in the spring of 2008.