Paul Saladino MD podcast

Today, Paul and Mike unpack their opinions about lipids. They talk about true risk for cardiovascular disease, primary versus secondary prevention, lipid lowering drugs, and share their thoughts on a recent podcast episode with Peter Attia.

*Produced by Mountain Valley Media

00:06:08 Blood markers & imaging techniques of metabolic function 

00:14:38 Gene mutations

00:20:28 LDL & Plaque burden

00:27:23 Money in statins

00:31:38 Downsides of lowering LDL

01:21:23 The downsides of popular cholesterol lowering drugs

01:41:07 Should we fear heart attacks?

01:45:23 PCSK9 Inhibitors

01:52:43 Risk profile of Statins 

01:53:02 Risk vs. reward of Ezetimibe

02:04:02 Primary vs. secondary prevention

Resources:

Debunking Sugar Claims: What Dr. Lustig Got Wrong On The Huberman Podcast:

https://www.youtube.com/watch?v=JcEmSgbMfco&t=2933s

Work With Mike: https://mikefave.com/

This week, Paul shares his most recent set of bloodwork in totality. He shares what he decides to order and why, and what bloodwork you may consider getting yourself. He also unpacks the importance of cortisol to DHEA sulphate radio and his cholesterol results.

00:00:00 Podcast begins

00:01:40 Traditional bloodwork 

00:05:40 MTHFR polymorphism: Does Paul take supplements?

00:10:10 Glucose & creatine

00:14:10 Electrolytes & insulin

00:23:10 Thyroid panel

00:26:18 Cortisol to DHEA sulphate ratio

00:32:20 Cholesterol panel

00:46:10 Hormones & Other results

00:50:20 Iron panel

00:52:40 What bloodwork should you get?

References:

July 2022 Bloodwork: https://www.youtube.com/watch?v=NuD9lWHMup8&t=669s

August 2022 Bloodwork: https://www.youtube.com/watch?v=1br0cDkYv3Y

December 2022 Bloodwork: https://www.youtube.com/watch?v=LQE3mrwaE8c

March 2023 Bloodwork: https://www.youtube.com/watch?v=vonHW14TTdg

DEXA scan reveals “side effects” of red meat: https://www.youtube.com/shorts/ZgRoz60ugnc

Cortisol, DHEA sulphate, their ratio, and all-cause and cause-specific mortality in the Vietnam Experience Study: https://pubmed.ncbi.nlm.nih.gov/20498139/

Cholesterol, coconuts, and diet on Polynesian atolls: a natural experiment: the Pukapuka and Tokelau island studies: https://pubmed.ncbi.nlm.nih.gov/7270479/

Cardiovascular risk factors in a Melanesian population apparently free from stroke and ischaemic heart disease: the Kitava study: https://pubmed.ncbi.nlm.nih.gov/8077891/

The effect of HMG-CoA reductase inhibitors on cognition in patients with Alzheimer's dementia: a prospective withdrawal and rechallenge pilot study: https://pubmed.ncbi.nlm.nih.gov/22921881/

Lipid profile of term infants on exclusive breastfeeding and mixed feeding: a comparative study: https://pubmed.ncbi.nlm.nih.gov/17327867/

Total cholesterol and all-cause mortality by sex and age: a prospective cohort study among 12.8 million adults: https://www.nature.com/articles/s41598-018-38461-y

Low-Density Lipoprotein Cholesterol Is Predominantly Associated With Atherosclerotic Cardiovascular Disease Events in Patients With Evidence of Coronary Atherosclerosis: The Western Denmark Heart Registry: https://pubmed.ncbi.nlm.nih.gov/36621817/

Get your bloodwork from ultalabs.com

While the food industry continues to follow its convenience, profit, addiction business model Paul and Anthony explain the ethos behind and process of creating Lineage Provisions, a radically transparent food company determined to play their part in elevating and celebrating food quality.

Check out Lineage Meat Sticks here: lineageprovisions.com/psmdyt

Paul has Human Biologist and founder of 10X Health Systems Gary Brecka on the podcast this week. As a previous life insurance adjuster, he talks about longevity through the lens of maintenance, being nutritionally optimal, and biohacking. They touch on adequate water filtration, all things genes & methylation, and food sourcing in the US.

*Produced by ⁠Mountain Valley Media

00:00:00 Podcast begins

00:01:23 What is fluoride and is it harmful?

00:07:30 How to filter your water

00:09:00 Western medicine & longevity

00:27:00 Food sourcing and big food

00:30:50 Cyanocobalamin

00:34:55 Folic acid

00:42:00 Gathering objective & subjective data

00:49:00 The importance of gene testing & methylation

On today’s podcast, Paul shares some new things he’s been experimenting with lately including eating more heart, supplementing with creatine, attempting to incorporate white rice as a carb source, and most excitingly, the launch of his new company: Lineage.

*Produced by ⁠Mountain Valley Media

This week, Paul talks to Mike Fave, critical care RN, about all things sugar & fructose. They share their thoughts on a recent podcast with Andrew Huberman and Alex Lustig, and why they disagree with certain points made about insulin, fruit juice, and fructose.

*Produced by ⁠Mountain Valley Media

On this week's podcast, Brad Marshall, evolutionary biologist, talks with Paul about how signaling to our body that winter is coming is not advantageous for humans and why humans may want to stop consuming olive oil. They do a deep dive into the human metabolism, what European diets are truly like, and touch on other kinds of oils & fats as well.

*Produced by ⁠Mountain Valley Media

00:00:00 Podcast begins

00:02:50 Brad’s weight loss journey

00:10:50 The human metabolism

00:15:10 How olive oil makes us fat

00:34:24 Deep dive into European diets

00:48:50 PREDIMED trial comparing different types of olive oil

00:51:05 De novo lipogenesis (DNL)

00:53:50 What happens when humans eat canola oil

00:59:20 A story about the Inuit & long-term ketosis

01:07:20 Takeaways about olive oil

Connect with Brad:

https://www.youtube.com/@fireinabottle3410

References:

Diabetes prevalence, 2021: https://ourworldindata.org/grapher/diabetes-prevalence

Trends of overweight, obesity and anthropometric measurements among the adult population in Italy: The CUORE Project health examination surveys 1998, 2008, and 2018: https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0264778.g004

OBESITY AMONG CHILDREN IN EUROPE: https://landgeist.com/2023/02/18/obesity-among-children-in-europe/

Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030: https://pubmed.ncbi.nlm.nih.gov/29886156/

Effects of free omega-3 carboxylic acids and fenofibrate on liver fat content in patients with hypertriglyceridemia and non-alcoholic fatty liver disease: A double-blind, randomized, placebo-controlled study: https://www.lipidjournal.com/article/S1933-2874(18)30362-3/fulltext

Quality of Dietary Fat Intake and Body Weight and Obesity in a Mediterranean Population: Secondary Analyses within the PREDIMED Trial: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315420/

This episode is my response to Layne’s video about seed oils. Due to the pervasive mainstream support for seed oils, I believe it’s extremely important to shed some light on the hidden truth behind these oils. There is a lot of conflicting evidence on seed oils out there. Looking at the totality of the evidence can be very misleading, so we must look at the details. By thoroughly breaking down each trial from Layne’s video, we can see massive flaws in the methods and designs of each study. Trans fat consumption by the control group and multifactorial interventions in the experimental group were the primary confounding variables.

Listen on YouTube: https://www.youtube.com/watch?v=8QhWNBXamCM&t=1s

Sign-up for Animal Based 30: https://heartandsoil.co/animalbased30/

Today, Paul has Dave Feldman on the podcast to discuss, in depth, a recent study that he conducted about LDL and cardiovascular risk and what this may mean for the future of medicine.

*Produced by Mountain Valley Media

00:03:30 The genesis of Dave’s most recent study

00:07:00 is FH a phenotype or genotype polygenetic vs monogenetic

00:22:30 Dave’s overall perspective while conducting studies

0:24:00 Diving into Dave Feldman’s most recent study: Does APOE-B cause atherosclerosis

00:42:30 How the medical community has received this study

00:46:30 Do credentials matter?

00:58:30 Thoughts on Statins

01:04:45 What alters lipid levels

01:13:30 Connect with Dave

References:

Twitter: @realdavefeldman

Instagram: @realdavefeldman

Youtube: youtube.com/@realdavefeldman

https://citizensciencefoundation.org/

Paul sits down in person with Calley Means to talk about the ins and outs of food industry corruption. Calley shares his firsthand experience as a previous consultant for Coca Cola, and unearths their strategies in keeping Americans addicted to sugar.

*Produced by Mountain Valley Media

00:02:00 The truth about Ozempic

00:08:15 Calley’s experience working for Big Pharma

00:27:45 When is Western medicine necessary?00:32:00 Addiction & targeting children

00:42:00 The infertility crisis

00:46:00 How Big Pharma manipulates the narrative

01:06:10 Food Compass & Dariush Mazaffarian

01:12:00 The path forward for medical professionals

01:35:20 Politics & disrupting the nutritional space

01:40:40 Ideas

01:45:40 Seed oils in infant formula

01:52:00 Conclusion & how to connect with

Calley

References:

https://www.truemed.com/