DeepMind’s artificial-intelligence system AlphaFold has predicted the three-dimensional shape of almost all known proteins. The company’s boss Demis Hassabis tells us how the AI was able to solve what was, for decades, biology’s grand challenge. Plus, Gilead Amit, The Economist’s science correspondent, explores the significance of the breakthrough for scientists tackling neglected diseases and designing new molecules. The leap forward could be AI’s greatest contribution to biology to date, but how else could machine learning help science? Kenneth Cukier hosts.

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