Base by Base - Music

This release contains only the music track from Base by Base Episode 369.

Song title: Break the Efflux
Original Base by Base episode: 369: NEK2 drives EBV-positive NHL pathogenesis

Article metadata:
Article title: NEK2 drives pathogenesis, drug resistance, and LMP1 expression in EBV-positive non-Hodgkin lymphoma
Journal: PNAS
DOI: 10.1073/pnas.2535550123
Reference: White MC, Lange PT, Stewart J, Damania B. NEK2 drives pathogenesis, drug resistance, and LMP1 expression in EBV-positive non-Hodgkin lymphoma. Proc Natl Acad Sci U S A. 2026;123:e2535550123. doi:10.1073/pnas.2535550123

Lyrics:
Verse 1
Midnight in the lab, bright screen, steady hand
A quiet enemy hides where the signals land
It teaches the cells how to never let go
Pumping out the cure like a practiced flow
But we traced the switch that keeps it all aglow

Pre-Chorus
Follow the current, it’s pulling the wires
One kinase spark lighting bigger fires
Hold that lever, watch the armor fall
When the gate goes down, the echoes call

Chorus
Break the efflux, cut the line, let it burn clean
Shut the engine down, make the dark unseen
When the pumps stop running, hope gets in
Turn resistance into paper-thin skin
Hit the switch—watch the tide begin

Verse 2
A viral whisper keeps the survival song
Names on the membrane humming all night long
Beta-catenin dreaming, myc in the glow
Pro-survival prayers in a brutal row
Till an iron-lock inhibitor says “No”

Bridge
Oxygen storms and a crimson flare
Inflammation rising through the air
Gasdermin tearing open the seal
A final warning the cells can feel
And the burden drops—more time is real

Final Chorus
Break the efflux, cut the line, let it burn clean
Drop the defenses, make the path unseen
When the pumps stop running, chemo gets in
Turn resistance into paper-thin skin
Hold the switch—let the new day begin

This release contains only the music track from Base by Base Episode 368.

Song title: Cut the Static, Save the Signal
Original Base by Base episode: 368: PARP1 and Amyloid: Protecting Neurons in a Familial AD Model

Article metadata:
Article title: PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer’s disease model
Journal: PNAS
DOI: 10.1073/pnas.2525028123
Reference: Jhaldiyal A., Kumari M., Guttman L. C., et al. PARP1 deficiency mitigates amyloid pathology, neurodegeneration, and cognitive decline in a familial Alzheimer’s disease model. PNAS (2026). DOI: 10.1073/pnas.2525028123

Lyrics:
Verse 1
Bright screen glow in the after-hours
Little shards in the synapse air
A whispered storm that never showers
Leaves a fracture everywhere

Pre-Chorus
When the damage starts to flicker
You can hear the cells go thin
But there’s a switch inside the circuit
Let the quiet fight begin

Chorus
Cut the static, save the signal
Don’t let the memory burn
Turn down PAR, break the spiral
Let the tide reverse and turn
Less made, more cleared—hold the line
We can slow the fall with time

Verse 2
Oligomers knock like broken rhythm
Set off alarms in neural code
But if PARP1 can’t feed the system
The heavy chain won’t overload

Bridge
Lower the blade that makes the fragments
Shift the gears that shape the cut
Raise the cleaner in the current
So the dark can’t pile up

Final Chorus
Cut the static, save the signal
Don’t let the memory burn
Turn down PAR, break the spiral
Let the tide reverse and turn
Less made, more cleared—hold the line
We can draw new maps from time

This release contains only the music track from Base by Base Episode 367.

Song title: Old Notes, New Bites
Original Base by Base episode: 367: Ancestral Splice Variation Fuels Cichlid Jaw Diversification

Article metadata:
Article title: Ancestral splice variation is a key substrate for rapid diversification in African cichlids
Journal: PNAS
DOI: 10.1073/pnas.2516477123
Reference: Singh P., Ahi E.P., Duenser A., Durdevic M., Gessl W., Schaeffer S., Gall J., Seehausen O., Sturmbauer C. Ancestral splice variation is a key substrate for rapid diversification in African cichlids. PNAS. 2026;123(20):e2516477123. doi:10.1073/pnas.2516477123

Lyrics:
Verse 1
In the lab light, I can hear it breathe
One gene, many voices underneath
Old blueprints folded in a quiet way
Waiting for a switch to turn and stay

Pre-Chorus
Not a brand-new page, just a different read
Hidden in the margins like a seeded need
Low and rare, it lingers out of sight
Then it rises when the timing’s right

Chorus
Old notes, new bites—watch the shape change fast
Ancient little variants waking from the past
Cut and stitch the message, make it fit the fight
One body, many answers in a single line
Old notes, new bites—feel the future bite

Verse 2
Some lines get louder, some stay in the blur
While expression moves, the splice can still outspur
And in the jaws where pressure turns to art
Fresh forms spark from a familiar start

Bridge
A minor set of brand-new turns appear
Quick-made meanings drawing near
In bone and cartilage, the pattern shifts its tone
From one code, a thousand ways to grow

Final Chorus
Old notes, new bites—watch the shape change fast
Ancient little variants waking from the past
Cut and stitch the message, make it fit the fight
Craniofacial dreams in fluorescent light
Old notes, new bites—now the whole world’s bright

This release contains only the music track from Base by Base Episode 366.

Song title: Circle in the Static
Original Base by Base episode: 366: BRCA1P1 suppresses antiviral and antitumor immunity

Article metadata:
Article title: Regulation of antiviral and antitumor immunity by the BRCA1 pseudogene in human cancers
Journal: Proceedings of the National Academy of Sciences (PNAS)
DOI: 10.1073/pnas.2528911123
Reference: Han YJ, Zhang J, Shariff M, Wu S, Khramtsova G, Nguyen LC, Peiffer DS, Li N, Lewicka A, Moore M, Piccirilli JA, Olopade OI. Regulation of antiviral and antitumor immunity by the BRCA1 pseudogene in human cancers. Proc Natl Acad Sci U S A. 2026;123(19):e2528911123. doi:10.1073/pnas.2528911123

Lyrics:
Verse 1
In the lab-light glow, where the cold gels shine,
A ghost of a gene drew a hidden line.
It looped into a circle, quiet and tight,
Holding back the thunder in the middle of the night.

Pre-Chorus
RelA at the doorway, keys in its hand,
But the lock kept turning like shifting sand.
Then we cut the whisper, broke the subtle chain,
And the room filled up with signal like rain.

Chorus
When the circle lets go, the sirens sing,
Interferon fire with a silver sting.
Turn on the warning, let the dark cells know:
You can’t hide forever when the defenses glow.

Verse 2
Tumor shadows talking in a borrowed tone,
Keeping the cytokines low, keeping danger prone.
But when that loop went missing, the story flipped fast,
More cracks in the armor, more weight on the past.

Bridge
Macrophage hands reach in, clear the floor,
T-cells press closer at the tumor door.
Apoptosis rising like a hard-earned dawn,
And the silent advantage is suddenly gone.

Final Chorus
When the circle lets go, the sirens sing,
Interferon fire with a silver sting.
Turn on the warning, let the dark cells know:
We’re built to survive—watch the defenses glow.

This release contains only the music track from Base by Base Episode 366.

Song title: Circle in the Static
Original Base by Base episode: 366: BRCA1P1 suppresses antiviral and antitumor immunity

Article metadata:
Article title: Regulation of antiviral and antitumor immunity by the BRCA1 pseudogene in human cancers
Journal: Proceedings of the National Academy of Sciences (PNAS)
DOI: 10.1073/pnas.2528911123
Reference: Han YJ, Zhang J, Shariff M, Wu S, Khramtsova G, Nguyen LC, Peiffer DS, Li N, Lewicka A, Moore M, Piccirilli JA, Olopade OI. Regulation of antiviral and antitumor immunity by the BRCA1 pseudogene in human cancers. Proc Natl Acad Sci U S A. 2026;123(19):e2528911123. doi:10.1073/pnas.2528911123

Lyrics:
Verse 1
In the lab-light glow, where the cold gels shine,
A ghost of a gene drew a hidden line.
It looped into a circle, quiet and tight,
Holding back the thunder in the middle of the night.

Pre-Chorus
RelA at the doorway, keys in its hand,
But the lock kept turning like shifting sand.
Then we cut the whisper, broke the subtle chain,
And the room filled up with signal like rain.

Chorus
When the circle lets go, the sirens sing,
Interferon fire with a silver sting.
Turn on the warning, let the dark cells know:
You can’t hide forever when the defenses glow.

Verse 2
Tumor shadows talking in a borrowed tone,
Keeping the cytokines low, keeping danger prone.
But when that loop went missing, the story flipped fast,
More cracks in the armor, more weight on the past.

Bridge
Macrophage hands reach in, clear the floor,
T-cells press closer at the tumor door.
Apoptosis rising like a hard-earned dawn,
And the silent advantage is suddenly gone.

Final Chorus
When the circle lets go, the sirens sing,
Interferon fire with a silver sting.
Turn on the warning, let the dark cells know:
We’re built to survive—watch the defenses glow.

This release contains only the music track from Base by Base Episode 365.

Song title: Pocket Full of Proof
Original Base by Base episode: 365: MEN1 mutations and menin inhibitor resistance

Article metadata:
Article title: CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials
Journal: Nature Communications
DOI: 10.1038/s41467-026-72685-1
Reference: Bourgeois, W., Rice, H.E., Wenge, D.V. et al. CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials. Nat Commun (2026). https://doi.org/10.1038/s41467-026-72685-1

Lyrics:
Verse 1
Bright screens in the midnight lab,
Tiny letters change the map.
One swap in the lock’s pure shape,
And the key don’t fit the latch.

Pre-Chorus
We watched the numbers rise and slide,
Same drug, different ride.
In the pocket where partners meet,
A single bump can shift the beat.

Chorus
In the binding pocket, sparks and stone,
Some changes stand, some changes don’t.
Push comes to pressure, cells hold the line,
Resistance learns in real time.
But now we see it, clean and close—
A pocket full of proof, and a better dose.

Verse 2
We edited base by base,
Let the variants show their face.
Some went broad, some played it sly,
One blocker fails, another might.

Bridge
Crystal-clear in black and white,
Steric clashes in the light.
When contact breaks, affinity falls,
And the living system answers the call.

Final Chorus
In the binding pocket, sparks and stone,
Some changes stand, some changes don’t.
Under drug-lit nights the pattern shines,
Resistance writes its own designs.
But now we name it, we choose our road—
A pocket full of proof, and a next-gen hope.

This release contains only the music track from Base by Base Episode 365.

Song title: Pocket Full of Proof
Original Base by Base episode: 365: MEN1 mutations and menin inhibitor resistance

Article metadata:
Article title: CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials
Journal: Nature Communications
DOI: 10.1038/s41467-026-72685-1
Reference: Bourgeois, W., Rice, H.E., Wenge, D.V. et al. CRISPR base editor screening identifies spectrum of MEN1 mutations impacting menin inhibitors in clinical trials. Nat Commun (2026). https://doi.org/10.1038/s41467-026-72685-1

Lyrics:
Verse 1
Bright screens in the midnight lab,
Tiny letters change the map.
One swap in the lock’s pure shape,
And the key don’t fit the latch.

Pre-Chorus
We watched the numbers rise and slide,
Same drug, different ride.
In the pocket where partners meet,
A single bump can shift the beat.

Chorus
In the binding pocket, sparks and stone,
Some changes stand, some changes don’t.
Push comes to pressure, cells hold the line,
Resistance learns in real time.
But now we see it, clean and close—
A pocket full of proof, and a better dose.

Verse 2
We edited base by base,
Let the variants show their face.
Some went broad, some played it sly,
One blocker fails, another might.

Bridge
Crystal-clear in black and white,
Steric clashes in the light.
When contact breaks, affinity falls,
And the living system answers the call.

Final Chorus
In the binding pocket, sparks and stone,
Some changes stand, some changes don’t.
Under drug-lit nights the pattern shines,
Resistance writes its own designs.
But now we name it, we choose our road—
A pocket full of proof, and a next-gen hope.

This release contains only the music track from Base by Base Episode 364.

Song title: C4 Under the Skin
Original Base by Base episode: 364: Peripheral C4 and Schizophrenia: A Neutrophil Gene–Protein Link

Article metadata:
Article title: Peripheral complement C4 protein in schizophrenia: Association with gene copy number and immune cell subtypes
Journal: PNAS
DOI: 10.1073/pnas.2536376123
Reference: Kalinowski A., Macaubas C., Guo H., et al. Peripheral complement C4 protein in schizophrenia: Association with gene copy number and immune cell subtypes. PNAS. 2026;123(20):e2536376123. doi:10.1073/pnas.2536376123

Lyrics:
Verse 1
White coat lights in a quiet room
Cold blue screens, the numbers bloom
In the bloodstream’s shadow, hidden lore
A silent signal knocking at the door

Pre-Chorus
Not in the flood, not in the plain
Not in the plasma we used to blame
It’s closer than we ever saw
A coded spark behind the draw

Chorus
C4 under the skin, won’t stay still
In the cell’s dark current, it learns your will
Copy by copy, the risk gets loud
A fire in the frontline, inside the crowd
C4 under the skin—now we know where it’s been

Verse 2
Neutrophils carry a private key
Monocytes hold it quietly
Gene-count echo in a protein trace
A tethered charge you can’t erase

Bridge
And if the mind feels stormy, pulled off track
There’s a thread in the body pulling back
Not a verdict, not a cure in hand
But a map you can measure, understand

Final Chorus
C4 under the skin, won’t stay still
In the cell’s dark current, it learns your will
Copy by copy, the signal’s proud
Not in the open—deeper, bound
C4 under the skin—turn the lock, read it in

This release contains only the music track from Base by Base Episode 363.

Song title: Entropy Between the Beats
Original Base by Base episode: 363: cfDNA size deconvolution reveals a 159‑bp nucleosomal pivot and tumor fragmentomic signatures

Article metadata:
Article title: Cell-free DNA size deconvolution resolves nucleosomal origins and reveals tumor-associated fragmentomic alterations
Journal: Nature Communications
DOI: 10.1038/s41467-026-72925-4
Reference: Zhou Z, Cooper WN, Cheng Z, et al. Cell-free DNA size deconvolution resolves nucleosomal origins and reveals tumor-associated fragmentomic alterations. Nat Commun (2026). https://doi.org/10.1038/s41467-026-72925-4

Lyrics:
Verse 1
Late-night glass, cold spin, bright screen glow
Tiny shards of truth in a river below
Lengths like footprints in a shadow parade
We sift the noise for the cuts that were made

Pre-Chorus
Not every short piece means the same kind of fight
Some hands break clean, some break in the light
Draw the curves, let the hidden peaks speak
Find the signal everybody used to miss

Chorus
Read it in the fragments, where the nucleosomes breathe
A line at one-five-nine, like a seam in the weave
Tumor tells a different story—wilder in the core
Higher inner entropy, knocking at the door
We don’t guess, we resolve it—hear the pattern get clear
From the mess to the message, the truth is near

Verse 2
Lorentzian halos, stacked like steps in time
Regular spacing, a mechanical rhyme
Shallow reads, still we fit it tight
R-squared high, like a target in sight

Bridge
And when phagocytes shorten, it’s a different kind of shift
Amplitude can rise, but the chaos doesn’t lift
So we take that ratio, intra to inter in the frame
Separating look-alikes that never shared a name
Now the ROC climbs higher—new eyes on the trace
A liquid whisper turning into evidence

Final Chorus
Read it in the fragments, where the nucleosomes breathe
A line at one-five-nine, like a seam in the weave
Tumor tells a different story—wilder in the core
Higher inner entropy, opening the door
We don’t guess, we resolve it—let the components align
From the blur to the breakthrough, we cross the line

This release contains only the music track from Base by Base Episode 362.

Song title: When the Bridge Breaks
Original Base by Base episode: 362: D614G Reshapes Spike Allostery and Speeds RBD Opening

Article metadata:
Article title: D614G reshapes allosteric networks and opening mechanisms of SARS - CoV - 2 spikes
Journal: PNAS
DOI: 10.1073/pnas.2504793123
Reference: Kearns FL, Bogetti AT, Calvó-Tusell C, et al. D614G reshapes allosteric networks and opening mechanisms of SARS-CoV-2 spikes. PNAS. 2026;123(19):e2504793123. doi:10.1073/pnas.2504793123

Lyrics:
Verse 1
Long nights, white light, and a restless screen,
I watch a hidden hinge in the in-between.
One tiny swap where the currents run,
And the whole locked door learns to come undone.

Pre-Chorus
A clasp lets go, the tension rewrites,
Signals travel like city lights.
Through quiet linkers, line to line,
The map of motion starts to shine.

Chorus
When the bridge breaks, the window swings wide,
A faster opening on the inside.
One small change, but it changes the game,
New shapes to see, new targets to name.
We ride that wave where the meanings live—
When the bridge breaks, the virus learns to give.

Verse 2
Two pathways humming—back and forth,
A message threaded from south to north.
What used to stall now slips on through,
Flex in the backbone, opening cue.
And later versions hold on tight,
With different knots in the folded night.

Bridge
Somewhere a “peel” reveals a different face,
A turn of the mask, a new kind of space.
What’s open changes what eyes can meet,
What hands can block, what shields can beat.
So we trace the dance, note by note,
To build the answers we can devote.

Final Chorus
When the bridge breaks, the window swings wide,
A faster opening on the inside.
One small change, but it changes the game,
New shapes to see, new targets to name.
So light the lab, let the rhythms live—
When the bridge breaks, we learn what to forgive.