Base by Base - Music

This release contains only the music track from Base by Base Episode 389.

Song title: Crotonylation, Hold the Line
Original Base by Base episode: 389: Crotonylation impedes c-Myc oncogenic activity

Article metadata:
Article title: Crotonylation impedes c-Myc oncogenic activity
Journal: PNAS
DOI: 10.1073/pnas.2530020123
Reference: https://doi.org/10.1073/pnas.2530020123

Lyrics:
Verse 1
Under white lights, the signals start to spark,
A switch on a protein in the dark.
A tiny mark where the messages align,
And suddenly the noise learns how to decline.

Pre-Chorus
Hands on the bench, eyes on the screen,
A lock clicks shut where it shouldn’t have been.
If the grip is broken, the storm can slow,
One quiet change in the afterglow.

Chorus
Crotonylation, hold the line,
Keep that wildfire from crossing the signs.
K289, K298—stay in place,
Let the runaway lose the race.
Crotonylation, hold the line.

Verse 2
When the mark is missing, the binder comes close,
Skp2 pulls tight like a knot in a rope.
The pages turn faster, the volume climbs,
More genes lit up in relentless time.

Bridge
And there’s a variant turning the key—K298N,
Less of the mark, and the pull begins.
In living tissue the shadow can grow,
But the map says where the pressure flows.
Break the handshake, change the deal,
Turn down the drive, make the damage kneel.

Final Chorus
Crotonylation, hold the line,
Keep that wildfire from crossing the signs.
K289, K298—stay in place,
Let the runaway lose the race.
Cut the Skp2 chain in time,
Crotonylation—hold the line.

This release contains only the music track from Base by Base Episode 388.

Song title: Borrowed Time, Brand-New Liver
Original Base by Base episode: 388: Base by Base | Episode 388 — In situ CAR‑macrophage alleviates liver fibrosis

Article metadata:
Article title: mRNA‑laden LNP‑enabled in situ CAR‑macrophage alleviates liver fibrosis via inhibiting activated HSCs and modulating the immune microenvironment
Journal: Proceedings of the National Academy of Sciences (PNAS)
DOI: 10.1073/pnas.2534673123
Reference: Huang X, Wang J, Hao J, et al. mRNA‑laden LNP‑enabled in situ CAR‑macrophage alleviates liver fibrosis via inhibiting activated HSCs and modulating the immune microenvironment. Proc. Natl. Acad. Sci. U.S.A. 2026;123(22):e2534673123. doi:10.1073/pnas.2534673123. Published May 29, 2026.

Lyrics:
Verse 1
In the dim-lit lab where the red lines grow,
Scar tissue stacking like a heavy shadow.
But a tiny message rides a lipid glow,
Knocking on the cells that started the battle.

Pre-Chorus
Find the marker, hit the right door,
Turn the hunters into healers once more.
Not forever—just enough to change the score,
A spark in the dark on the cellular floor.

Chorus
Send the mRNA, let it light the switch,
Teach the macrophage to lock onto the itch.
Clear the FAP signal, cut the tethered pain,
Break down the walls, let the blood run clean again.
We don’t need forever, we just need right now—
Watch the scar unwind, watch the body remember how.

Verse 2
It’s a quick-lived badge on an immune-cell frame,
A focused grip, not a runaway flame.
Phagocytosis rising like a drumline beat,
Old collagen crumbling under moving feet.

Bridge
Syk to the signal, NF-kappa to the roar,
Matrix starts to loosen where it locked before.
MMP12 humming through the crowded space,
And the tissue turns—slowly—toward a gentler place.

Final Chorus
Send the mRNA, let it light the switch,
Teach the macrophage to lock onto the itch.
Clear the FAP signal, cut the tethered pain,
Break down the walls, let the blood run clean again.
Transient and targeted—yeah, that’s the vow—
Watch the scar unwind, watch the body remember how.

This release contains only the music track from Base by Base Episode 387.

Song title: When the Shield Gets Thin
Original Base by Base episode: 387: Homotypic Dengue Reinfections and Long-Term Antibody Decay

Article metadata:
Article title: Long-term antibody dynamics challenge the paradigm of lifelong homotypic immunity to dengue virus
Journal: PNAS
DOI: 10.1073/pnas.2606206123
Reference: Andrade J, Mitard de Girardie A, Huang AT, et al. Long-term antibody dynamics challenge the paradigm of lifelong homotypic immunity to dengue virus. PNAS. 2026;123(22):e2606206123. doi:10.1073/pnas.2606206123

Lyrics:
Verse 1
We thought the lightning only struck one time
Same face, same fever, same border line
But numbers in the blood don’t hold that bright
They rise like a flare, then slip from sight

Pre-Chorus
A fast fall in the first few moons
Then a long, slow fade through quiet afternoons
Years pass by in a steady slide
And the old “always” doesn’t always survive

Chorus
So we count the echoes in the vein
Protection isn’t permanent, it wanes
Most of it moves in silence, unseen
A shield gets thin, but life goes on between
And when the bite comes back around
We learn what immunity leaves on the ground

Verse 2
In crowded days where mosquitoes hum
Nearly every hit feels like nothing comes
But hidden sparks can still redraw the chart
Age writes patterns on the antibody arc
And after more than one hard-earned scar
The drop slows down—still drifting far

Bridge
Not every vaccine can promise “never again”
If the curve keeps bending, if the memory thins
So plan for the long night, not just the start
Watch the slow decline like a beating heart
Boost the light when the signal turns dim
Build the model where reality lives within

Final Chorus
Yeah, we count the echoes in the vein
Protection isn’t permanent, it wanes
Most of it moves in silence, unseen
A shield gets thin, but life goes on between
And when the same storm wears a different crown
We don’t look away—we track it down

This release contains only the music track from Base by Base Episode 386.

Song title: Double the Light
Original Base by Base episode: 386: Genome Doubling and the Bioeconomy

Article metadata:
Article title: Polyploidy: A macromutational force pushing bioeconomic developments
Journal: Proceedings of the National Academy of Sciences (PNAS)
DOI: 10.1073/pnas.2522065123
Reference: Peeters MKR & Van de Peer Y (2026). Polyploidy: A macromutational force pushing bioeconomic developments. Proc. Natl. Acad. Sci. U.S.A. 123:e2522065123. https://doi.org/10.1073/pnas.2522065123

Lyrics:
Verse 1
In the lab glow, we tilt the dice of life
One more whole blueprint, stitched into the drive
Cells get wide like a sunrise in the grain
A giant kind of ordinary, rewriting what we tame

Pre-Chorus
Copies of the code, singing out of time
Switching on new colors in the metabolic line
But every bright expansion has a shadow on the floor
So we measure, we listen, we ask for something more

Chorus
Double the light, let it grow
Bigger leaves, deeper roots below
New compounds in the air we breathe
Strength in the heat, in the storm, in the sea
Double the light—careful, true
A boom of promise, and a risk to move
We hold both truths in view

Verse 2
Fields and forests dreaming heavier wood
Biofuel rivers where the old stalk stood
Algae turning sunlight into medicines and dye
Yeast that keeps on working when the pressure runs high

Bridge
Triploid quiet—no wild escape
A safer harvest in a shifting landscape
But genomes can tremble, outcomes can split
So we test what it builds, and we test what it costs, bit by bit

Final Chorus
Double the light, let it grow
More from the same, in a brighter flow
Resilience written in a second chance
A wider palette for the future’s hands
Double the light—steady, wise
Build it with wonder, audit the signs
We turn the key, and we rise

This release contains only the music track from Base by Base Episode 385.

Song title: Double the Light, Double the Shadow
Original Base by Base episode: 385: Growth under Pressure: Polyploidy Induced by Stress

Article metadata:
Article title: Growth under pressure: The pros and cons of polyploidy induced by stress
Journal: PNAS
DOI: 10.1073/pnas.2522063123
Reference: Sarabia Olivera L, Belato PB, Silva J, Selmecki A, Fox DT, Roeder AHK. Growth under pressure: The pros and cons of polyploidy induced by stress. PNAS. 2026;123(22):e2522063123. doi:10.1073/pnas.2522063123

Lyrics:
Verse 1
Under the microscope, the night runs long
A little heat, a hard hit, something goes wrong
Red sparks in the cell like a warning flare
Then the genome breathes deep, takes on extra air

Pre-Chorus
Skip the checkpoint, slide past the line
A cycle rewired in real time
One wound can teach a tissue to cope
But every shortcut bends the rope

Chorus
Whole world doubling under pressure tonight
Two sets of stories in the same small light
It can heal the break, make the weak one brave
Or shake the ground where the futures are saved
Double the light, double the shadow we face

Verse 2
Mitotic bypass, endoreplication—new roads
Failed cytokinesis, heavy-lift loads
From plants to animals, from fungi to skin
A backup blueprint when survival is thin

Bridge
But echoes stack up, and the math gets strange
Instability whispers, chromosomes change
Resistance rises, the bad cells learn
So we chase the switchbacks where lessons turn

Final Chorus
Whole world doubling under pressure tonight
Two sets of stories in the same small light
It can build back strength, help the lost regrow
Or fuel the chaos we’re trying to slow
Double the light, double the shadow—hold tight

This release contains only the music track from Base by Base Episode 384.

Song title: CisR on the Switch
Original Base by Base episode: 384: RNA Brake on Cholera Phage: CisR Controls CTXϕ

Article metadata:
Article title: A 3’UTR-derived small RNA modulates the life cycle of the cholera toxin–encoding filamentous phage, CTXϕ
Journal: PNAS
DOI: 10.1073/pnas.2535142123
Reference: Haycocks JRJ, O’Driscoll E, Sprenger M, Thriene K, Jung E-M, Siemers M, Lippegaus A, Krautwurst S, Grainger DC, Papenfort K. A 3’UTR-derived small RNA modulates the life cycle of the cholera toxin–encoding filamentous phage, CTXϕ. PNAS. 2026;123(23):e2535142123. doi:10.1073/pnas.2535142123

Lyrics:
Verse 1
In the glow of lab-screen midnight, a whisper splits from the tail,
A small-cut message from the afterword, riding a ribonuclease trail.
It finds a waiting chaperone, it learns a lock-and-key,
And hovers near the start of fire, where proteins want to be.

Pre-Chorus
When the crowd gets louder, when the carbon signs turn bright,
Two sentries lift a signal up to keep the timing right.
A hidden line becomes a lever, gentle but precise,
And stops the spark from catching fast with one clean slice of ice.

Chorus
CisR on the switch, on the edge of the start,
Hands on the ribosome door, keeping toxins apart.
Hold the coat, slow the tide, let the storm lose its grip,
One small RNA can change the whole trip.

Verse 2
A filament wants a highway, a coat wants to rise,
But base-paired in the doorway, the invitation dies.
Less Cep in the darkened lane, fewer threads released,
And what could spread like wildfire turns to embers, then to peace.

Bridge
Not a siren—more a checkpoint where the busy signals meet,
Quorum voices in the airwaves, hunger tapping out a beat.
Between the cell and what escapes, a quiet rule is drawn:
Translate a little slower now, and see the danger gone.

Final Chorus
CisR on the switch, on the edge of the start,
Hands on the ribosome door, keeping toxins apart.
Hold the coat, slow the tide, let the storm lose its grip,
One small RNA can change the whole trip.

This release contains only the music track from Base by Base Episode 383.

Song title: Trans Signals in the Bloodlight
Original Base by Base episode: 383: Genetics of the Circulating Proteome: pQTLs, Pathways, and Disease Links

Article metadata:
Article title: Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome
Journal: Cell
DOI: 10.1016/j.cell.2026.03.049
Reference: Koprulu M., Smith-Byrne K., Ferolito B.R., et al., 2026. Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome. Cell 189, 3339–3357. https://doi.org/10.1016/j.cell.2026.03.049

Lyrics:
Verse 1
Late-night screens and a sea of names,
Thirty-eight crowds, one pulse in frames,
Proteins drifting like paper kites,
Genes pull strings from distant sites.

Pre-Chorus
Not just next door, not the closest key,
The loudest levers move silently,
Across the map, through hidden lanes,
A distant switch rewrites the veins.

Chorus
It’s trans, trans—across the line,
Distant hands draw the design,
Sugar-coats and secret roads,
Turning whispers into codes,
Read the blood like city light—
Find the driver, not the hype.

Verse 2
Glyco gears in the dark run true,
N-linked loops in a midnight queue,
Liver sparks, immune drums,
Cell-type choirs where the signal comes.

Bridge
Biomarkers shine, but they can mislead,
Cis says “cause,” while the charts just “read,”
Triangulate—don’t fall in love,
Follow the effector from glove to glove.

Final Chorus
It’s trans, trans—across the line,
Distant hands draw the design,
From protein storms to disease routes,
We tag the targets, we test the doubts,
New paths open, sharp and bright—
Find the driver, not the hype.

This release contains only the music track from Base by Base Episode 382.

Song title: Old Codes, New Blood
Original Base by Base episode: 382: How animal blood cells evolved from unicellular ancestors

Article metadata:
Article title: Animals have expanded the evolutionary legacy of unicellular ancestors in blood cells
Journal: PNAS
DOI: 10.1073/pnas.2528110123
Reference: Nagahata Y, Ishidae T, Satou Y, Nishimura Y, Kaitani R, Leong JCK, Oda-Ishiie I, Carmona-Rivas M, Najle SR, Ruiz-Trillo I, Kohtsuka H, Abeg S, Ikuta K, Miura T, Kawamoto H, Casacuberta E, Ogasawara M, Irieda N. Animals have expanded the evolutionary legacy of unicellular ancestors in blood cells. PNAS. 2026;123(23):e2528110123. doi:10.1073/pnas.2528110123

Lyrics:
Verse 1
Before the bodies learned to breathe and run,
A single cell kept watch beneath one sun,
A borrowed spark, a Fos-lit, ancient tune,
That taught the dark to swallow danger whole.

Pre-Chorus
Same old signal, new disguise,
Through open gates and changing skies,
From quiet hunger to a shield—
One simple script the world could wield.

Chorus
Old codes, new blood—turn the pages, feel the flood,
From first-time phagocytes to guardians in the mud,
Split into fire, split into bite, drawing borders in the night,
We didn’t start from nothing—
We learned to fight with light.

Verse 2
Then came the granules, sharp with protease rain,
A mast-born lightning for the parasite’s chain,
And later branches carved the lines we know:
Killer songs, red rivers, clot and flow.

Bridge
At the edge of gills, a first small training ground,
Where future hunters learned a quieter sound,
And even now, inside the marrow’s glow,
Those old potentials rise and rearrange the show.

Final Chorus
Old codes, new blood—turn the pages, feel the flood,
From first-time phagocytes to guardians in the mud,
From ancient Fos to modern wars, the map keeps opening doors,
We carry deep instructions—
And we can be more.

This release contains only the music track from Base by Base Episode 381.

Song title: Light Writes the Map
Original Base by Base episode: 381: Light-written spatial barcodes enable tunable multiomic sequencing (BALI)

Article metadata:
Article title: Spatially tuneable multiomic sequencing using light-driven combinatorial barcoding of molecules in tissues
Journal: PNAS
DOI: 10.1073/pnas.2527896123
Reference: Battistoni G, Torres-Garcia S, Sia CY, Corriero S, Boquetale C, Williams E, et al. Spatially tuneable multi-omics sequencing using light-driven combinatorial barcoding of molecules in tissues. Proc Natl Acad Sci U S A. 2026;123(21):e2527896123. doi:10.1073/pnas.2527896123

Lyrics:
Verse 1
Late nights, bright screens, a tissue like a sky
We aim a thin beam where the answers like to hide
A quiet click—uncaged, the lock becomes a key
And tiny names are stitched where we decide to see

Pre-Chorus
One more round, let it run, let it bind in time
Digits stack like steps in a rising climb
From a few to a field, from a blur to a sign
We don’t chase the dark—we draw the line

Chorus
Light writes the map, right where it matters most
Tag the words and the open doors, coast to coast
In the same thin slice, hear the message, see the gates
One section, two stories, and the future calibrates

Verse 2
Some regions whisper different, some chromatin shouts
Peaks in the silence, turning maybes into routes
We tune the scale—wide view or razor-tight detail
Save what’s worth the reads, let the wasted cycles fail

Bridge
Not painted after—written in the living scene
A combinatorial pulse, clean and machine
Two-four-eight—keep the pattern growing strong
From hundreds to the millions, watch the grid sing along

Final Chorus
Light writes the map, right where it matters most
Tag the words and the open doors, coast to coast
Every cycle, every mark, brings the picture into focus
We don’t just read the tissue now—
We compose it, and it shows us

This release contains only the music track from Base by Base Episode 380.

Song title: Barcode the Breakthrough
Original Base by Base episode: 380: Prime-SGE maps drug-resistance variants at scale

Article metadata:
Article title: A multiplex, prime editing framework for identifying drug resistance variants at scale
Journal: Cell Genomics
DOI: 10.1016/j.xgen.2026.101167
Reference: Abadie FMC, Suiter CC, Smith NT, et al. A multiplex, prime editing framework for identifying drug resistance variants at scale. Cell Genomics. 2026;6:101167. doi:10.1016/j.xgen.2026.101167

Lyrics:
Verse 1
Long nights under white-blue screens
We redraw the letters in the genes
One clean change, no shattered strands
A future built with steady hands

Pre-Chorus
Load the library, let it run
Thousands of maybes under one sun
Then pressure hits like medicine
And only the answers rise again

Chorus
We barcode the breakthrough, line by line
Watch the resistant sparks align
Different drugs, different maps in the fire
We don’t guess—we climb higher
If a variant stands, we learn its name
And turn tomorrow’s fight in our favor again

Verse 2
Covalent grip, then slip away
Non-covalent finds another way
Some hide quiet, some shout loud
In the data’s moving crowd

Bridge
But the edits don’t land the same each time
Low signal ghosts in the timeline
Still we trace what survives the dose
And follow the ones that matter most
From dish to living proof, it grows

Final Chorus
We barcode the breakthrough, line by line
Let the resistant sparks align
Rank the risks, make the next design
Turn the lock before it rewinds
Even when the signal’s thin, we aim again
’Cause knowledge is how the cure begins