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President Donald Trump and Prime Minister Benjamin Netanyahu have indicated that an objective of the US-Israel war with Iran is regime change. But is that possible? What will happen in Tehran now that Supreme Leader Ayatollah Ali Khamenei is dead? Will we see regime change? Or a changed regime?

We speak to the BBC's chief international correspondent Lyse Doucet, who has covered Iran for years and is one of the few Western journalists to report from inside the country in recent months.

Photo credit: Abedin Taherkenareh/EPA/Shutterstock

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US President Donald Trump has said he took the decision to launch a war against Iran because it was the "last, best chance" to stop the country's regime.

In his first live remarks since US strikes on Iran, the president said the US military is continuing to carry out “large-scale combat operations”.

The US and Israel struck Iran on Saturday, killing Supreme Leader Ayatollah Ali Khamenei. The Israeli military has since launched new strikes on Tehran, but the US defense secretary said that the operation against Iran will not lead to an "endless war".

Earlier, new Iranian strikes were reported on a major gas plant in Qatar, where the Ministry of Defence later said it had shot down two Iranian aircraft, seven missiles and five drones.

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Conflict has spread across the Middle East after Iran's Supreme Leader, Ayatollah Ali Khamenei, was killed during strikes launched by the US and Israel on Saturday.

Iran has responded by launching missiles and drones across the region, targeting Israel, Bahrain, Kuwait, Qatar, the United Arab Emirates, Jordan, Saudi Arabia, Cyprus and ships passing through the Strait of Hormuz.

The BBC's Security Correspondent Frank Gardner answers your top questions on the escalating war in the Middle East - what’s happening between the US, Israel and Iran, why it’s spreading region-wide, and what it means for global politics, security and energy markets.

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Europe is "absolutely supportive" of US action in Iran, according to Secretary General of Nato Mark Rutte.

The US and Israel struck Iran on Saturday, killing the country's Supreme Leader Ayatollah Ali Khamenei.

In an interview with the BBC, Rutte said that Europe is "really stepping up" in the wake of this weekend's operations in Iran.

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UK Prime Minister Keir Starmer has said the UK's decision not to join the US-Israeli strikes on Iran was “deliberate”.

The prime minister also said “the best way forward for the region and the world is a negotiated settlement” but he called Iran's response to the attacks "outrageous”.

It comes after the US and Israel struck Iran on Saturday, killing the country's Supreme Leader Ayatollah Ali Khamenei. The Israeli military has launched new strikes on Tehran.

Meanwhile, new Iranian strikes have been reported on a major gas plant in Qatar and in Saudi Arabia.

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The United States has urged its citizens in Lebanon to leave the country immediately.

It comes after the Lebanese health ministry said Israeli attacks in Beirut and southern Lebanon killed at least 31 people. Israel said it was responding to Hezbollah attacks.

"The security situation in Lebanon is volatile and unpredictable. Airstrikes have occurred throughout the country, especially in the south, the Beqaa, and parts of Beirut", the US Embassy in Beirut said.

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Resident Evil turns 30 years old on March 22nd, three decades after the original survival‑horror classic arrived in 1996. To mark the anniversary - and the launch of Resident Evil Requiem (RE9) - Mel Ramsay speaks with two of the voices shaping the modern era of the franchise.

Nick Apostolides, the voice and motion-capture actor for Leon S. Kennedy in the Resident Evil franchise, (Resident Evil 2 remake, Resident Evil 4 remake, and the Netflix series Resident Evil: Infinite Darkness), talks fandom, manifestation, motion capture, leaks, and what it means to carry one of gaming’s most iconic characters into a new generation.

Nicole Tompkins, who plays Jill Valentine in the Resident Evil 3 remake and Resident Evil: Death Island, reflects on legacy characters, fan stories, camp vs. grit, and why Jill remains such an inspirational figure for women in games.

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Ayatollah Ali Khamenei, who ruled Iran for more than 30 years, was killed over the weekend in joint US-Israeli strikes.

In Iran, his death was met with an outpouring of grief by his supporters, while many across the country and in the diaspora met the news with jubilation and a tentative sense of hope.

But what happens now?

President Trump has urged Iranians to “seize control of your destiny, and to unleash the prosperous and glorious future that is close within your reach,” but how realistic are the prospects of them forming a new – and significantly different - government? And how will the weakened regime retaliate against the US and Israel’s strikes?

Caroline Hawley, Diplomatic Correspondent for the BBC, joins Asma Khalid to discuss what happens next.

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Chapters:

00:00 Trump announces strikes against Iran

01:28 How the strikes unfolded

02:48 Why strike now?

05:35 What will happen to Iran after the fighting stops?

07:12 Who was Ayatollah Ali Khamenei?

10:10 What was life like for Iranians under Khamenei?

12:00 Who is in charge of Iran now?

15:20 What is the likelihood of an uprising?

18:10 Who might come next in Iran?

24:00 Conclusions

Airlines are continuing to cancel and divert flights in the Middle East after the US and Israel launched strikes against Iran.

Flights in and out of airports in Tel Aviv, Dubai, Doha and other international hubs in the region have been suspended.

The UK Foreign Office is warning British citizens against all but essential travel to Bahrain, Kuwait, Qatar and the United Arab Emirates.

Iran has launched attacks on the Gulf states as part its retaliation to US and Israeli strikes which began early on Saturday.

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US President Donald Trump has posted a video statement on Truth Social saying the US will "deliver the most punishing blow" to the Iranian regime.

The president warned "there will likely be more" US deaths after three service members were killed.

He said "combat operations" against Iran will continue "until all of our objectives are achieved”.

It comes after Israel and the US struck Iran on Saturday, killing the country's Supreme Leader Ayatollah Ali Khamenei. The Israeli military now says it has launched additional strikes on Tehran.

Meanwhile, new Iranian strikes have been reported across the Middle East.

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