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Military strikes by the US and Iran have taken place across multiple cities in Iran.

Explosions were reportedly heard across the country, including: Isfahan, Qom, Karaj, and Kermanshah.

Israel says "several senior figures" from the Iran regime have been "eliminated". Prime Minister Benjamin Netanyahu has said that there are “growing signs” that amongst the dead are Iran’s Supreme Leader, Ayatollah Ali Khamenei.

Iran retaliated by launched strikes targeting Israel and other sites in the Middle East - including Bahrain, Dubai, Doha and Kuwait.

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The US and Israel have today launched “major combat operations” against Iran, according to US President Donald Trump, with “several senior figures” from the Iran regime having been “eliminated” according to Israel officials.

Israeli Prime Benjamin Netanyahu has said that there are “growing signs” that amongst the dead are Iran’s Supreme Leader, Ayatollah Ali Khamenei.

The attacks, which come after weeks of negotiations over Iran’s nuclear programme, have resulted in apparent Iranian strikes in response across the Middle East, with countries such as the UAE, Qatar, Bahrain, and Kuwait – places with US military bases, or that are allied to the US – being targeted.

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Iranian Foreign Ministry spokesman Esmail Baghaei says he's "not in a position to confirm" whether members of Iran's senior leadership targeted by the US and Israel are unharmed.

Earlier, Iranian Foreign Minister Abbas Araghchi told NBC News that Supreme Leader Ayatollah Ali Khamenei is “alive” as far as he is aware but Iran “may have lost one or two commanders”.

Following reports that Khamenei's offices and residences were targeted, BBC News chief international correspondent Lyse Doucet pressed Baghaei to confirm or deny the reports.

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More strikes by the US and Iran have taken place in Iran.

Explosions were reportedly heard across the country, including: Isfahan, Qom, Karaj, and Kermanshah. The office of the supreme leader and the presidential office were also reportedly targeted.

The Israel Defense Forces (IDF) said its strikes in Tehran targeted locations where senior political and security figures were gathered.

Iran retaliated by launching strikes targeting Israel and other sites in the Middle East - including Bahrain, Dubai, Doha and Kuwait.

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Iranian Foreign Ministry spokesman Esmail Baghaei says he's "not in a position to confirm" whether members of Iran's senior leadership targeted by the US and Israel are unharmed.

Earlier, Iranian Foreign Minister Abbas Araghchi told NBC News that Supreme Leader Ayatollah Ali Khamenei is “alive” as far as he is aware but Iran “may have lost one or two commanders”.

Following reports that Khamenei's offices and residences were targeted, BBC News chief international correspondent Lyse Doucet pressed Baghaei to confirm or deny the reports.

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Today, we look at US and Israeli attacks on Iran.

US President Donald Trump has described ongoing "major combat operations" and called for Iranian government forces to lay down their arms.

Iranian forces say they have struck a US naval base in Bahrain and across the region in response.

Earlier, Israel's defence minister said Israel had launched a "pre-emptive attack" against Iran, with explosions heard across the country.

Chief international correspondent Lyse Doucet, just back from Iran, joins to explain what's happening, why, and what could happen next.

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Iranian forces say they have struck a US naval base in Bahrain, as Iran launched strikes across the region in retaliation for a "massive" and ongoing attack against it by the US and Israel.

Elsewhere across the region, the UAE, Qatar and Kuwait - all home to US military bases - said they have intercepted missiles in their air space.

In Doha, Qatar's defence ministry said it had intercepted several missiles apparently targeting the al-Udeid air base, the largest American base in the region.

US President Donald Trump has described ongoing "major combat operations" and called for Iranian government forces to lay down their arms.

Earlier, Israel's defence minister said Israel had launched a "pre-emptive attack" against Iran, with explosions heard across the country.

This comes after weeks of threats and negotiations over Iran's nuclear programme.

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Airlines serving the Middle East have cancelled or diverted flights after the US and Israel launched deadly strikes on Iran.

Sites in Iran including in the capital, Tehran, have been targeted in the attacks on Saturday. Iran has been accused of launching retaliatory strikes on Israel and several other nations hosting US facilities in the region.

British Airways, Virgin Atlantic and Wizz Air are among carriers to greatly reduce their schedules to destinations in the Middle East, citing safety concerns.

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The Israeli military says Iran has launched retaliatory strikes on Israel after President Donald Trump confirmed that the US and Israel launched "major combat operations" in Iran.

Explosions - thought to be Iranian attacks - have also been heard in the United Arab Emirates, Bahrain and Kuwait.

President Trump posted an eight-minute video on his social media platform, Truth Social, confirming the US’s involvement in the strikes, which hit five cities in Iran today.

It comes after weeks of threats and negotiations over Iran's nuclear programme.

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Israel and the US have launched an attack on Iran, with explosions reported in five cities including the capital, Tehran.

President Donald Trump confirmed that the US has launched "major combat operations" in Iran, while Israeli Defence Minister Israel Katz says his country launched a "pre-emptive" strike on Tehran.

The US president posted an eight-minute video on his social media platform, Truth Social claiming that Iran, "attempted to rebuild their nuclear program and to continue developing long range missiles that can now threaten our very good friends and allies in Europe, our troops stationed overseas and could soon reach the American homeland."

A state of emergency has also been declared in Israel in anticipation of retaliatory strikes.

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