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A revolutionary new gene therapy for an aggressive and previously incurable form on blood cancer has had dramatic results.

Two-thirds of patients in a trial of the treatment have gone into what doctors are calling “deep remission”, showing no signs of their previously untreatable leukaemia.

The treatment has been pioneered at Great Ormond Street Hospital and University College Hospital in London. It involves editing the DNA of donor immune cells to make them resistant to chemotherapy and able to target cancer cells.

The same technology has been used to treat other illnesses, including sickle cell disease and may have potential to reverse other forms of cancer.

It’s the latest in a series of recent breakthroughs using new forms of gene therapy to modify DNA. Recent successes have lead to new treatments for Huntingdon’s disease and Hunter syndrome.

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Today, we discuss President Trump’s new vision for global security, one that is creating a lot of criticism in Europe.

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The 33-page document called the National Security Strategy suggests Europe is facing "civilisational erasure" and does not cast Russia as a threat to the US. Russia says the strategy is “largely consistent” with their vision.

Security correspondent Frank Gardner and former UK ambassador to the US Lord Kim Darroch join Adam to discuss what this means for Europe.

Plus, we discuss what has happened in Syria a year after former President Bashar al-Assad was overthrown. Adam chats with Mina Al-Lami from BBC Monitoring.

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The Royal Navy has unveiled some of the ways it plans to counter what the government regards as an increasingly serious threat from Russia to the UK's undersea infrastructure.

They include new technologies and prototypes, such as unmanned surface vessels, helicopters and autonomous submarine gliders.

The Ministry of Defence said in a statement that the programme was "in direct response to the resurgence in Russian submarine and underwater activity".

The government says there has been a 30% increase in the number of Russian vessels threatening UK waters in the last two years.

Russia says its the UK government that's being provocative.

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Ukraine's President Volodymyr Zelensky met key European allies in London on Monday as he faces US pressure to reach a swift peace deal with Russia.

Zelensky held talks with UK Prime Minister Sir Keir Starmer, French President Emmanuel Macron and the German Chancellor Friedrich Merz.

The meeting came amid US efforts to get Moscow and Kyiv to sign up - quickly - to a plan to end the war in Ukraine.

For Kyiv, the crucial issues are the question of ceding territory to Russia as part of any peace deal and obtaining strong security guarantees to ensure that Moscow respects an eventual agreement.

The big names Starmer hosted in London discussed hugely significant issues - not only for Ukraine's future, but for the security of the continent as a whole.

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With his first Formula 1 world championship, Lando Norris joins an illustrious sporting club.

His third-place finish at the Abu Dhabi Grand Prix was enough to secure him the driver's title for the first time, breaking Max Verstappen's four-year winning streak.

Only 35 drivers in the 75-year history of the sport have won the F1 title.

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Ex-footballer Joey Barton has been given a suspended jail sentence for "grossly offensive" social media posts about broadcaster Jeremy Vine and football pundits Lucy Ward and Eni Aluko.

Barton was given six months in custody, suspended for 18 months.

He was also made to do 200 hours of unpaid work in the community, pay more than £20,000 in costs, and given restraining orders.

The former Premier League footballer was found guilty last month after comparing Aluko and Ward to serial killers Fred and Rose West and calling Vine a "bike nonce" in posts sent between January and March 2024.

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Ukraine's President Volodymyr Zelensky is meeting key European leaders in London on Monday, as Ukraine's allies plan their response to an ongoing US push for Kyiv to accept concessions in peace talks.

The leaders of France and Germany will join Zelensky and UK Prime Minister Keir Starmer at No 10 Downing Street as they seek to ensure any deal deters a future Russian attack.

The high-level meeting follows three days of talks in Florida, where Zelensky's chief negotiator pushed for changes to a White House plan widely considered to accommodate central Kremlin demands.

The US and Ukraine said there was progress but US President Donald Trump appeared to criticise Zelensky on Sunday, saying he "hasn't read" the draft.

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One year ago today, Bashar al-Assad's 24-year rule of Syria came to an end, bringing a close to 13 years of brutal civil war.

On 8 December 2024, Assad stepped down as Syria's president and fled to Russia, marking one of the most significant political shifts in the Middle East in decades.

Twelve months on, the dust has begun to settle but the country is still grappling with the immense social, political and emotional toll left behind.

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Thousands of civilians along the Thailand-Cambodia border are fleeing after an escalation of violence between the two countries.

A Thai military spokesperson said air force jets bombed Cambodian military positions after a Thai soldier was killed in an exchange of fire along the disputed border.

Cambodia has said that four civilians were killed in Thai Army gunfire in its northern border provinces of Preah Vihear and Oddar Meanchey.

Both sides have accused each other of starting the violence, which is the most serious confrontation since their agreed ceasefire in July.

Clashes have also been reported in Thailand's north-eastern Si Sa Ket and Ubon Ratchathani provinces.

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Laura, Paddy, and Joe Pike discuss the government's plan to get almost one million young people back to work, plus the foundation of Your Party and the latest tory defection to Reform.

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