Antibiotics are frequently prescribed for pets with urinary tract infections (UTIs), but antimicrobial resistance (AMR) is a real-life dilemma that presents a One Health challenge to veterinary clinicians. VetFolio Voice podcast host Dr. Cassi discusses the latest guidelines for treating UTIs in small animal patients and important pharmacological concepts for antibiotics with Dr. Natalie Young, who is board certified through the Board of Pharmacy Specialists in sterile compounding. They address the dangers posed by antimicrobial resistance and the “catch-22” circumstance veterinarians face as they balance their “gut checks” versus their desire to be good antimicrobial stewards.