During the 2023 ESVS Annual Meeting in Belfast we sat down with PIs of the BEST CLI trial, Drs. Alik Farber and Matt Menard, to dig deeper into the interpretation of the results of this landmark trial. That conversation has become a series of 3 Q&A podcasts, of which this is the first. Find out in what patients the trial results are applicable and so we should look out for in our everyday clinical practice.