In the wake of widespread adoption of artificial intelligence (AI) in critical infrastructure, education, government, and national security entities, adversaries are working to disrupt these systems and attack AI-enabled assets. With nearly four decades in vulnerability management, the Carnegie Mellon University Software Engineering Institute (SEI) recognized a need to create an entity that would identify, research, and identify mitigation strategies for AI vulnerabilities to protect national assets against traditional cybersecurity, adversarial machine learning, and joint cyber-AI attacks. In this SEI podcast, Lauren McIlvenny, director of threat analysis in the SEI's CERT Division, discusses best practices and lessons learned in standing up an AI Security Incident Response Team (AISIRT).