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Tom Masterson, COO of Deep Genomics, on AI drug discovery where precision beats creativity. He explains how the company's siRNA model picked an approved cholesterol drug out of 3,500 candidates for a target it had never seen, why it designs toxic molecules on purpose, and how a COO runs a company where the lab and the software move on different clocks.
In this episode, Tom and Michael discuss:
About Tom:
Tom Masterson is chief operating officer of Deep Genomics, the Toronto company building biological foundation models for RNA drug discovery. He joined in business development and strategy, then served as chief of staff to founder Brendan Frey and to CEO Brian O'Callaghan before becoming COO. He partners with the CEO on board and investor relations, owns the company's project management and executive functions, and is the person who turns Deep Genomics' science into its business story. Before Deep Genomics he was the first employee at Microbiome Insights in Vancouver, worked in contract research and healthcare design strategy, and founded Caregiver Support, a startup that helped family caregivers through medical crises. He started his career selling dental lasers at a medical device company. He holds a BSc in cell biology and genetics from the University of British Columbia and an MBA from Harvard Business School.
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Paul Kedrosky of SK Ventures says AI capex is driving up to 70 percent of US GDP growth, and most of it is now borrowed. He walks through the money map, the 2029 maturity wall, why AI tokens are a deflationary commodity, and three ways the AI bubble reaches companies that never touch a data center.
In this episode, Paul and Michael discuss:
About Paul:
Paul Kedrosky is co-founder and managing partner of SK Ventures and a fellow at MIT’s Initiative on the Digital Economy, where his research focuses on AI and the future of work. A former Wall Street technology equity analyst, he consults with major asset managers, is a regular contributor at CNBC and Bloomberg, and co-hosts a weekly show with former Twitter CEO Dick Costolo.
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Lior Eldan, co-founder and COO of Moburst, has reinvented what his agency sells three times, from app store optimization to AI products. He explains why replacing people with AI is backwards, why managers have to do the work, and why automating a broken process just gets the AI blamed.
In this episode, Lior and Michael discuss:
About Lior:
Lior Eldan is co-founder and COO of Moburst, the digital marketing agency he started in 2013 with Gilad Bechar after the two met as HR officers in the Israeli army. Moburst began in app store optimization, grew through acquisitions including Uproar and Kitcaster, and now sells AI products alongside its services. Adweek has named it one of the fastest-growing agencies in the world.
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Part 2 of 2. Part 1 is here: https://betweentwocoos.com/65
In part 1, Joe Yaffe explained how an orbital data center works. This time, the question is
In this episode, Joe and Michael discuss:
About Joe:
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Part 1 of 2. Part 2 drops later this week.
Joe Yaffe had climbed as high as the ladder goes. Fifteen years at Latham & Watkins,
In this episode, Joe and Michael discuss:
About Joe:
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Riikka Söderlund is the chief operating officer at Katana Cloud Inventory, a Finland-based platform that helps small product businesses run inventory, manufacturing, and multi-channel sales. She and host Michael Koenig discuss how AI search is affecting product discovery, why an out-of-stock product is invisible to an AI chat, and why she thinks marketing is an underused path to the COO seat. Along the way: six-week sprints instead of quarters, why Katana opened its API while SAP closed theirs, and the brand that discovered it had been selling at a loss.
Riikka Söderlund is the chief operating officer at Katana Cloud Inventory, where she runs the commercial side of the business. She spent two decades in marketing, starting in Helsinki ad agencies, then a decade in consumer marketing, before joining Katana as VP of marketing and later CMO. She studied communications, and she credits narrative building as the skill that carried across from marketing into operations. Katana serves merchants in over 70 countries, with more than $3 billion in gross merchandise value flowing through the platform.
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Rick Marini, co-founder of Rails and former COO of Grindr, joins Between Two COOs to explain why he would rather be a great COO than a good CEO. He and host Michael Koenig cover the CFIUS-forced sale that put Grindr in play, the day-one culture reset that ended two and a half years later in a $2 billion New York Stock Exchange debut, the three-months-of-cash pivot that saved Tickle in the dot-com crash, and how he evaluates moats now that AI lets anyone stand up a company in a weekend.
Rick Marini has founded and operated consumer technology companies for 26 years. He co-founded Tickle in 1999, founded and led BranchOut to 800 million profiles and $49 million raised, and served as COO of Grindr from its 2020 acquisition through its $2 billion NYSE debut. He has been an angel investor in 60 companies, 15 of them unicorns, started Protocol Ventures, the first crypto fund of funds, and is now co-founder of Rails, a crypto perpetuals exchange.
Read more and explore related coverage at betweentwocoos.com/rick-marini-good-ceo-vs-great-coo. (update if slug changes)
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Michael Koenig talks with Wade Foster, co-founder and CEO of Zapier, about running the company for 14 years without a CEO safety net and without ever naming a COO. Wade explains why he thinks hiring a chief operating officer from outside a company is a coin flip, why Zapier put AI transformation inside the chief people officer role instead of naming a dedicated AI executive, and why he believes AI adoption is fundamentally an organizational and people problem rather than a technology problem. The conversation covers Zapier's “code red” response to GPT-4, the pricing decision that traded short-term revenue for long-term customer trust, and what changed in Wade's own leadership style over 14 years in the same seat.
Wade Foster co-founded Zapier and serves as its CEO. Zapier is a workflow automation platform that connects thousands of software tools and now powers billions of automated actions each month. Under Wade's leadership, Zapier grew to roughly 850 employees and a multi-billion dollar valuation while raising only a small seed round after Y Combinator.
Read the full episode page at Between Two COOs: Wade Foster on why AI adoption is a people problem.
Zulema Quintans runs operations at an energy company, and she has a clear theory about why goals fail. This is a conversation about making OKRs actually work, and how AI is changing the operator's job.
In this episode, Zulema and Michael discuss:
- Why most OKRs never get done, and the one link that fixes it
- Running OKRs as an operating system, not a quarterly ritual
- Aiming for 70 percent completion, and the Federer mindset behind it
- Being directive without micromanaging
- The $200 billion commercial buildings spend on energy, and how much is wasted
- How Noda connects to legacy buildings and cleans messy data
- Automated demand management, and the knob that quietly saves energy
- Why AI makes this a golden age for operators
- Where the human still has to stay in the loop
Chapters
00:00 Cold open: the energy waste problem
01:05 Meet Zulema and Noda
01:45 From Juilliard ballet to COO
03:30 Holding focus and flexibility
06:01 Why OKRs fail, and the 70% rule
08:41 Top-down meets bottom-up OKRs
13:09 Making OKRs the operating system
15:55 Inside Noda: climate tech for buildings
19:19 Turning messy building data usable
20:39 The modular path to automation
22:50 AI cuts onboarding from weeks to hours
24:50 The Buildings IoT acquisition
25:46 AI, the COO role, and human judgment
32:09 The five-year view for buildings
34:42 A warehouse full of sensors
About Zulema:
Zulema Quintans is the chief operating officer of Noda, an energy and building intelligence platform for commercial real estate, where she leads product, operations, and customer success. Before Noda she held leadership roles at Arcadia, American Express, and Bain & Company. She began her career as a professional ballet dancer trained at Juilliard.
Resources mentioned:
- Roger Federer, 2024 Dartmouth commencement address: https://www.youtube.com/watch?v=pqWUuYTcG-o
Connect with Zulema:
- LinkedIn: https://www.linkedin.com/in/zulema-quintans-36152223/
- Noda: https://noda.ai
Connect with Michael:
- LinkedIn: https://www.linkedin.com/in/michael-koenig514
- Building Helm: https://helmapp.ai
Subscribe to Between Two COOs:
- Apple Podcasts: https://podcasts.apple.com/us/podcast/between-two-coos/id1635533318
- Spotify: https://open.spotify.com/show/2NjVgGm6mqLPEbJUvHnHEH
- Newsletter: https://betweentwocoos.com
Watch on YouTube.
In this episode, Peter and Michael discuss:
About Peter: Peter Rojas co-founded Gizmodo and Engadget, two publications that changed how people understand technology. He has been an operator and investor across AOL, Meta, and BetaWorks, where he was a founder and VC. Today he leads new product development at Mozilla and runs Mozilla Pioneers.
00:00 Cold open
01:46 The email that started the show
03:33 Startup vs building inside a company
06:57 The corporate product numbers game
11:03 Vibe coding and Mozilla Pioneers
15:13 When a trusted brand is the advantage
18:04 Why incumbents lose the next wave
21:58 Meta's metaverse bet vs AI
25:44 If I were running Meta
29:02 Was the VR bet a failure
30:27 Why coordination breaks at scale
35:07 Fear, focus, and the CEO filter
38:56 How Mozilla runs on KPIs
40:30 The founder who hid his idea
46:33 Where to find Peter
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From the publisher's feed