On the game preview episode this week, Matt & Ryan begin with Josh Allen, who's coming off two turnovers in the fourth quarter against the Los Angeles Chargers last week. The 49ers forced the Rams into 4 last week and if Allen can't protect the ball this week, the guys envision serious trouble (6:03). Then on the other side, the Bills defense is going to have its hands full trying to stop the run with speedy runners Raheem Mostert and Jeff Wilson. How can the Bills slow them down (11:34)? The guys also hit on some other big storylines going into this game, including whether star linebacker Matt Milano could make his return (27:58). Then they dive into a couple interesting matchups (33:45) and provide their predictions (42:59).

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