Chemical synthesized RNA can be used in the development of mRNA vaccines and genome editing tools, as well as the development of mRNA amplification-based diagnostics.https://mrna.creative-biolabs.com/custom-chemical-synthesis-of-mrna.htm

Modified mRNAs can readily be obtained from any DNA template using RNA polymerases in a short time.https://mrna.creative-biolabs.com/custom-chemical-synthesis-of-mrna.htm

reagents for mRNA delivery, genome editing mRNA, reporter gene mRNA, growth factor mRNA, mRNA kits, enzymes for mRNA research, and nucleotide products for mRNA research

https://mrna.creative-biolabs.com/category-mrna-products-443.htm

 In vitro transcription (IVT) is an elegant way to obtain highly pure and uniform mRNA oligonucleotides of lengths ranging from about 15 to several thousand nucleotides.https://mrna.creative-biolabs.com/category-in-vitro-transcription-vector-452.htm

Cytokines are low molecular weight soluble proteins produced by cells stimulated by immunogens, mitogens or other factors, including interleukins, interferons (IFN), lymphokines, colony-stimulating factors (CSF), chemokines, monoclonal factors and other factors. https://mrna.creative-biolabs.com/category-cytokine-mrna-455.htm

Antibodies are immunoglobulins produced by B lymphocytes during their differentiation into plasma cells that bind specifically to the corresponding antigen. Antibodies can be divided into five major classes (IgG, IgA, IgM, IgD, IgE), which have a protective effect on the organism. Antibody mRNAs don't require nuclear localisation to mediate protein translation, but can be translated directly into target proteins or immunogenic activation of the immune response in vivo by using genetic sequence of the virus.https://mrna.creative-biolabs.com/category-antibody-mrna-479.htm

Messenger ribonucleic acid (mRNA), a type of RNA molecule that can be found in various cells. In general, the structure of mRNA is often composed of a 5' cap, two untranslated regions (5' UTR and 3' UTR), a coding domain, a 3' poly(A) tail. mRNA can be produced during the process of transcription in the nucleus. Normally, primary transcript mRNA (pre-mRNA) will be created at the early stage of transcription. https://mrna.creative-biolabs.com/applications-of-mrna-as-research-tools.htm

mRNA is potentially beneficial for vaccination because it can provide adjuvant activity to drive dendritic cell (DC) maturation and thus elicits a strong sputum and B cell immune response. Our optimization services include the following aspects:

Nucleosides-modified mRNA

Sequence-optimized mRNA

Self-amplifying mRNA

HPLC (high-performance liquid chromatography)-purified

FPLC (fast protein liquid chromatography)-purified

Addition of adjuvant

https://mrna.creative-biolabs.com/mrna-pharmacology-optimization.htm

IVT mRNA can be created by incorporating naturally occurring modified nucleosides such as 2-thiouridine, pseudouridine, 5-methylcytidine, 5-methyluridine, or N6-methyladenosine into the IVT mRNA. This has been shown to suppress both the intrinsic adjuvant activity of IVT mRNA as well as its inhibitory effects on translation.

https://mrna.creative-biolabs.com/mrna-pharmacology-optimization.htm

Use of modified nucleosides for modulating innate immune activation

Engineering favorable secondary structures by sequence optimization

https://mrna.creative-biolabs.com/mrna-pharmacology-optimization.htm