In this special 20th-anniversary episode of Bladder Cancer Matters, host and survivor Rick Bangs sits down with leading urologic oncologist Dr. Sia Daneshmand to explore a new bladder cancer therapy: Johnson & Johnson's newly FDA-approved INLEXZO™. Dr. Daneshmand—who helped lead its clinical trials—breaks down how this "pretzel-shaped" intravesical delivery system works, why it's showing some of the highest response rates yet for BCG-unresponsive disease and what patients can realistically expect in terms of side effects, treatment schedule, and quality of life. Together, they discuss the future of drug-delivery technology in bladder cancer and why this moment can offer hope to bladder cancer patients.

In this powerful and deeply personal episode of Bladder Cancer Matters, host Rick Bangs talks with survivor and advocate Danny Gereg, who shares how a shocking 2023 bladder cancer diagnosis became the catalyst for a total life transformation.

Once diabetic, alcoholic, and obese, Danny rebuilt his body and spirit—losing over 100 pounds, reclaiming his health, and finding purpose as a voice for others navigating the challenges of cancer, sexuality, and recovery. With candor and humor, he discusses the physical and emotional realities of treatment, the life-changing support of his wife, and how BCAN's community helped him rediscover hope. This unflinching, inspiring conversation is a testament to resilience, love, and the belief that even after cancer, life can be rebuilt—stronger than ever.

In this episode of Bladder Cancer Matters, host and survivor Rick Bangs sits down with Dr. Mark Schoenberg—renowned urologist and Chief Medical Officer at UroGen® Pharma—for a wide-ranging conversation about the evolution of bladder cancer research, treatment, and patient advocacy. Dr. Schoenberg shares the story behind BCAN's founding, the early challenges of raising awareness, and the innovations that are reshaping care today, including the development of non-surgical therapies like ZUSDURI™ (mitomycin) for intravesical solution, a prescription medicine used to treat adults with a type of cancer of the lining of the bladder called low-grade intermediate-risk non-muscle invasive bladder cancer (LG-IR-NMIBC) after you have previously received bladder surgery to remove the tumor and it did not work or is no longer working. From his decades of patient-centered work to his role in pioneering new approaches with UroGen, Dr. Schoenberg offers insights into where the field has been and the promising future ahead. Tune in to hear a fascinating mix of history, science, and hope for patients and families impacted by bladder cancer.

Please see the link to the full Prescribing Information on the podcast web page or available at www.zusduri.com.

ZUSDURI Prescribing Information

• ZUSDURI Patient Information
• Holzbeierlein J, Bixler BR, Buckley DI, et al. Diagnosis and treatment of non-muscle invasive bladder cancer: AUA/SUO guideline: 2024 amendment. J Urol. 2024;10.1097/JU.0000000000003846.

ZUSDURI (mitomycin) for intravesical solution is a prescription medicine used to treat adults with a type of cancer of the lining of the bladder called low-grade intermediate-risk non-muscle invasive bladder cancer (LG-IR-NMIBC) after you have previously received bladder surgery to remove tumor and it did not work or is no longer working.

ZUSDURI™ Important Safety Information

You should not receive ZUSDURI™ if you have a hole or tear (perforation) of your bladder or if you have had an allergic reaction to mitomycin or to any of the ingredients in ZUSDURI™.

Before receiving ZUSDURI™, tell your healthcare provider about all of your medical conditions, including if you:

• have kidney problems
• are pregnant or plan to become pregnant. ZUSDURI™ can harm your unborn baby. You should not become pregnant during treatment with ZUSDURI™. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with ZUSDURI™.

Females who are able to become pregnant: You should use effective birth control (contraception) during treatment with ZUSDURI™ and for 6 months after the last dose.

Males being treated with ZUSDURI™: You should use effective birth control (contraception) during treatment with ZUSDURI™ and for 3 months after the last dose.

• are breastfeeding or plan to breastfeed. It is not known if ZUSDURI™ passes into your breast milk. Do not breastfeed during treatment with ZUSDURI™ and for 1 week after the last dose.

How will I receive ZUSDURI™?

• You will receive your ZUSDURI™ dose from your healthcare provider 1 time a week for 6 weeks into your bladder through a tube called a urinary catheter. It is important that you receive all 6 doses of ZUSDURI™ according to your healthcare provider's instructions.
• If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment.
• During treatment with ZUSDURI™, your healthcare provider may tell you to take additional medicines or change how you take your current medicines.

After receiving ZUSDURI™:

• ZUSDURI™ may cause your urine color to change to a violet to blue color. Avoid contact between your skin and urine for at least 24 hours.
• To urinate, males and females should sit on a toilet and flush the toilet several times after you use it. After going to the bathroom, wash your hands, your inner thighs, and genital area well with soap and water.
• Clothing that comes in contact with urine should be washed right away and washed separately from other clothing.

The most common side effects of ZUSDURI™ include: increased blood creatinine levels, increased blood potassium levels, trouble with urination, decreased red blood cell counts, increase in certain blood liver tests, increased or decreased white blood cell counts, urinary tract infection, blood in your urine.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to UroGen Pharma at 1-855-987-6436.

Please see ZUSDURI Full Prescribing Information, including the Patient Information, for additional information.

JELMYTO® Important Safety Information

You should not receive JELMYTO® if you have a hole or tear (perforation) of your bladder or upper urinary tract.

Before receiving JELMYTO®, tell your healthcare provider about all your medical conditions, including if you

• are pregnant or plan to become pregnant. JELMYTO® can harm your unborn baby. You should not become pregnant during treatment with JELMYTO®. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with JELMYTO®. Females who are able to become pregnant: You should use effective birth control (contraception) during treatment with JELMYTO® and for 6 months after the last dose. Males being treated with JELMYTO®: If you have a female partner who is able to become pregnant, you should use effective birth control (contraception) during treatment with JELMYTO® and for 3 months after the last dose.
• are breastfeeding or plan to breastfeed. It is not known if JELMYTO® passes into your breast milk. Do not breastfeed during treatment with JELMYTO® and for 1 week after the last dose.
• Tell your healthcare provider if you take water pills (diuretic).

How will I receive JELMYTO®?

• Your healthcare provider will tell you to take a medicine called sodium bicarbonate before each JELMYTO® treatment.
• You will receive your JELMYTO® dose from your healthcare provider 1 time a week for 6 weeks. It is important that you receive all 6 doses of JELMYTO® according to your healthcare provider's instructions. If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment. Your healthcare provider may recommend up to an additional 11 monthly doses.
• JELMYTO® is given to your kidney through a tube called a catheter.
• During treatment with JELMYTO®, your healthcare provider may tell you to take additional medicines or change how you take your current medicines.

After receiving JELMYTO®:

• JELMYTO® may cause your urine color to change to a violet to blue color. Avoid contact between your skin and urine for at least 6 hours.
• To urinate, males and females should sit on a toilet and flush the toilet several times after you use it. After going to the bathroom, wash your hands, your inner thighs, and genital area well with soap and water.
• Clothing that comes in contact with urine should be washed right away and washed separately from other clothing.

JELMYTO® may cause serious side effects, including:

• Swelling and narrowing of the tube that carries urine from the kidney to the bladder (ureteric obstruction). If you develop swelling and narrowing, and to protect your kidney from damage, your healthcare provider may recommend the placement of a small plastic tube (stent) in the ureter to help the kidney drain. Tell your healthcare provider right away if you develop side pain or fever during treatment with JELMYTO®.
• Bone marrow problems. JELMYTO® can affect your bone marrow and can cause a decrease in your white blood cell, red blood cell, and platelet counts. Your healthcare provider will do blood tests prior to each treatment to check your blood cell counts during treatment with JELMYTO®. Your healthcare provider may need to temporarily or permanently stop JELMYTO® if you develop bone marrow problems during treatment with JELMYTO®.

The most common side effects of JELMYTO® include: urinary tract infection, blood in your urine, side pain, nausea, trouble with urination, kidney problems, vomiting, tiredness, stomach (abdomen) pain.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit http://www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to UroGen Pharma at 1-855-987-6436.

Please click here for JELMYTO® Full Prescribing Information, including the Patient Information, for additional information.

In this powerful episode of Bladder Cancer Matters, host Rick Bangs welcomes Dr. Rick Zera, a retired surgical oncologist who spent decades treating breast cancer before unexpectedly becoming a bladder cancer patient himself. Dr. Zera shares his remarkable story of moving from the operating room to the patient's chair, beginning with a shocking diagnosis of an extremely rare and aggressive bladder cancer. He speaks candidly about the delays and frustrations he faced in getting timely care, the difficult choices between treatment options, and the emotional toll of navigating his own cancer journey after a career spent guiding others through theirs.

What follows is an honest, deeply human conversation about risk, resilience, and perspective. Dr. Zera reflects on what he learned about himself, his colleagues, and the vital role of support systems—from family and friends to social workers and fellow patients.

Bladder Cancer Matters just hit a huge milestone—our 100th episode! In this special 20th anniversary edition of our Partners in Progress series, host Rick Bangs talks with Drew and Erica, whose mom Fran is living with bladder cancer, about what it means to be a caregiver. From music-filled car rides to difficult treatment decisions, they share honest, heartfelt stories of resilience, laughter, hope and the power of family. 💙 Tune in and be inspired by their journey—and celebrate this milestone with us!

In this powerful episode of Bladder Cancer Matters, host Rick Bangs sits down with Dr. Ruchika Talwar, a leading urologic oncologist and health policy expert, to tackle the growing issue of financial toxicity in bladder cancer care. With candid insights and clear explanations, Dr. Talwar breaks down the hidden and rising costs patients face—from co-pays and lost wages to caregiver burdens and high drug prices—and explains why bladder cancer is the most expensive cancer per patient in the U.S. Listeners will gain practical tips to navigate the system, avoid financial pitfalls, and advocate for support—all while learning why open conversations with healthcare providers matter more than ever. Whether you're a patient, caregiver, or healthcare professional, this episode sheds light on a critical but often overlooked side effect of cancer: the financial toll. Don't miss this eye-opening discussion.

In this powerful episode of Bladder Cancer Matters, host and survivor Rick Bangs sits down with Dr. Brian Zheng of Brigham and Women's Hospital and Harvard Medical School to explore a deeply personal yet often overlooked topic: life after a radical cystectomy. Dr. Zheng shares candid insights on the different types of incontinence, how they uniquely affect men and women, and—most importantly—practical tips and treatment options that can dramatically improve quality of life. From behavioral changes and physical therapy to products, medications, and surgical solutions, this episode arms listeners with actionable advice and much-needed hope. If you or a loved one are living with a neobladder, this is an essential listen.

In this compelling episode of Bladder Cancer Matters, host Rick Bangs sits down with Dr. Vijay Kasturi, Chief Medical Officer at CG Oncology, for a must-hear conversation that blends science, heart, and hope. From the personal loss that fuels his passion to the groundbreaking clinical trials underway for Cretostimogene—an innovative investigational therapy targeting non-muscle invasive bladder cancer—Dr. Kasturi offers a behind-the-scenes look at how CG Oncology is working to change the game for patients. Whether you're a patient, caregiver, clinician, or advocate, this episode delivers crucial insights into new horizons for bladder cancer treatment.

In this powerful episode of Bladder Cancer Matters, host Rick Bangs talks with Deb Wells, a survivor of high-grade upper tract urothelial cancer (UTUC), who shares her emotional and eye-opening journey to diagnosis and treatment. After months of misdiagnoses and repeated ER visits, Deb finally learned the truth behind her symptoms—an experience that will resonate with many bladder cancer patients, especially women. She opens up about the importance of being an informed patient, finding the right medical team, and leaning on a support system when facing uncertainty.

Deb's story is both inspiring and practical, filled with advice for navigating complex medical decisions, coping with treatment side effects, and embracing life during and after cancer. If you or someone you love has been impacted by bladder or upper tract urothelial cancer, this episode offers hope, clarity, and a powerful reminder that no one has to face this journey alone. Don't miss this honest and uplifting conversation.

Can you really just take out part of the bladder? It's one of the most common questions bladder cancer surgeons hear—and in this episode of Bladder Cancer Matters, host Rick Bangs sits down with renowned urologic oncologist Dr. John Gore to break it all down. From TURBTs to partial cystectomies, they explore when bladder-sparing approaches are appropriate, what the real risks and benefits are, and how treatment choices affect long-term outcomes. Whether you're a patient, caregiver, or advocate, this episode is packed with the kind of honest, expert insight that can help you make more informed decisions.