Despite strong recommendations for colorectal cancer screening, many eligible patients are still unscreened because of access and convenience issues. Emerging blood-based screening tests may help expand participation, but important questions remain about their ability to detect advanced precursor lesions and how they compare with established screening approaches. Joining Dr. Peter Buch to discuss the evolving role of blood-based colorectal cancer screening and what clinicians should know about these new testing strategies is Dr. Aasma Shaukat. Dr. Shaukat is the Robert M. and Mary H. Glickman Professor of Medicine at the NYU Grossman School of Medicine and the Director of Outcomes Research in Gastroenterology.