Bloody Minded

This is getting out of hand, now there are two of them (Dr Nicks). Join the boys as they make a new friend and strongly consider upgrading the house Nicholas to this newer shiny model, and learn a bit about Burkitt Lymphoma along the way!

TIMESTAMPS

 0:57 - **** Is Dead
 9:52 - The immune system as Starcraft units
 11:53 - MYC - The Common Culprit
 17:25 - Subtypes of Burkitts
 19:23 - The Discovery of EBV
 29:04 - Banelings = Spontaneous TLS
 35:25 - Histology of Burkitts
 37:43 - Flow cytometry for Burkitts
 42:47 - Treatment of Burkitts
 47:11 - Differentials for Burkitts
 49:43 - Take Home Messages 

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The Bloody Minded crew hit the road on a tour of Australia’s big things, and this week’s stop is the biggest of them all: the Big Cell. Joining us as tour guide (and DJ, with an all-Phil-Collins playlist) is Dr Jed Kitson, final-year haematology registrar, here to rescue us from a run of indolent lymphomas and talk about the most common aggressive lymphoma in Australia. From R-CHOP to Axi-cel, from Hans to CNS staging, this is a roadtrip you just can't miss.

TIMESTAMPS

00:56 - The boys take Jed on a roadtrip!
02:47 - Who is this Jed?
03:36 - What IS DLBCL?
05:25 - Classifying DLBCL
07:32 - Epidemiology
08:42 - Presentation of DLBCL
11:03 - Diagnosing DLBCL
14:11 - Pathological features on biopsy
15:58 - Determining cell of origin (COO)
20:03 - DZSig
22:38 - Completing the biopsy examination
23:39 - BCL2, BCL6 and MYC
29:26 - Limitations of FISH
30:36 - Workup in new DLBCL
33:07 - CNS risk
35:17 - Treatment - RCHOP as frontline
37:51 - Trying to improve on RCHOP
43:53 - CNS prophylaxis
45:17 - Assessing treatment response
46:04 - Options in relapsed/refractory DLBCL
48:00 - Options in late relapse
54:00 - Take home messages

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As Nick once again leaves Bashar and Cale unsupervised they attend Blood 2026 and speak with the finest Australian and New Zealand haematologists in Auckland. They cover a pot pourri of myeloma, iron replacement, HHT, CAR-T, Cheese and mostly lets be honest, garbage. 

Thanks to Dr Georgina Calov, Dr Lise Kempler, Dr Miles Ma, Dr Michel Lu, Dr Alison Chandler for putting up with us and we'll resume our scheduled programming as usual. 

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Look! It’s a follicular lymphoma! No wait, it’s a DLBCL! No wait, it’s a CLL? Actually is it a leukaemia? Join Nick, Cale and Bashar as they wrestle with the morphological and prognostic chameleon that is Mantle Cell Lymphoma. With all the bad bits of an indolent lymphoma and all the bad bits of an aggressive one – as Michael Jackson would say, it's bad (really, really bad). Except when it isn't. Who knows what mantle is doing – we don't think it knows itself

TIMESTAMPS

0:57 - Conspiracies 101
 3:47 - Epidemiology of MCL
 6:41 - Morphology of MCL
 7:41 - Flow cytometry for MCL
 9:16 - Cyclin D1
 14:49 - Risk Stratification for MCL
 17:20 - Ki67 - what is it
 19:15 - MRD for MCL?!
 22:47 - Treatment of MCL
 30:52 - Do we need an autoSCT?
 33:20 - Leukaemic Non-Nodal MCL
 36:27 - Cyclin D1 negative MCL
 37:43 - Take Home Messages

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What do you call a small B-cell lymphoma that isn't CD5 positive, isn't CD10 positive and generally refuses to wear any of the usual hats? Probably marginal zone lymphoma. Possibly. Maybe.

Join the Bloody Minded crew as we head to the edge of the follicle where the bloodstream's customs officers live, and look at what happens when they go rogue. Discover how to cure a cancer with a PPI, and why we're so very bored of the NF-κB pathway.

TIMESTAMPS

0:57 - Whisky sponsorship pls and thx
2:11 - What the marginal zone is/isn't 
6:28 - Marginal zone B cells
8:35 - Classifying marginal zone lymphoma
11:05 - Epidemiology
12:09 - Pathophysiology in gastric MALT
16:42 - Stimuli for other marginal lymphomas
19:55 - Pathological features of marginal
21:20 - Splenic MZL
25:43 - Flow cytometric features
30:13 - Workup of MZL
32:20 - Management strategies
37:53 - Prognosis
38:56 - High grade transformation
40:07 - Take home messages

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Join the boys as they frollickular through the molecular and macro-cular particulars of follicular lymphoma this week. While you're at it, please sign our petition to allow Bashar back into the aquarium and take a gander at Cale's tiny hands.

Timestamps

00:52 - Bashar is banned from the Aquarium a second time
02:13 - Follicular Lymphoma Overview
06:07 - Pathophysiology of FL
09:50 - Follicular Lymphoma In Situ (Old Name)
11:54 - Clinical & Morphology
17:24 - Identifying FL in the Lab
20:08 - Staging & Workup
23:07 - Prognostication
25:56 - To treat or not to treat?
29:31 - Treating Upfront
33:59 - Treating Relapse
37:43 - Transformation
41:12 - Summary

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Why do haematologists get excited over smudges on a film? What is the deal with that whole IGHV situation? Why is Bashar no longer welcome at the zoo? Join us as we find the answers to these common haematology questions and more in a foray into Chronic Lymphocytic Leukaemia!

TIMESTAMPS

0:55 - No animals were harmed in the making of this bit
 4:13 - Epidemiology of CLL
 5:56 - Pathophysiology of CLL
 11:42 - MBL
 12:36 - SLL
 15:54 - Clinical features of CLL
 18:18 - Lab features of CLL
 20:50 - Flow cytometry for CLL
 23:46 - Staging of CLL
 25:38 - Prognostication of CLL
 27:38 - Indications for treatment in CLL
 31:04 - Treatment approaches for CLL
 41:53 - Response assessment in CLL
 42:49 - Richter's transformation
 44:47 - Take Home Messages

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Welcome to the Land of the Lymphoid. Eighty-odd subtypes, one grid. Help us break our cellular pathways and journey further into our lymphoid season as we ask the only two questions that matter - B or T, fast or slow, forget the platypuses - and build the framework we'll be filling in for the rest of the series. Bring a hat, the savannah is hot. 

0:52 - Lymphoid Planet
2:50 - Leukaemia vs Lymphoma
4:51 - Two Questions & A Recap
8:49 - Identifying a Cell
16:22 - Indolent vs Aggressive (and Super-Aggressive)
22:37 - Indolent B-Cell
23:21 - Aggressive B-Cell
25:27 - Indolent T-Cell
25:44 - Aggressive T-Cell
27:42 - Wait... what about Hodgkins
31:28 - A Framework
32:21 - General Lymphoma Workup
38:19 - Staging
40:12 - Review

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

For the first time, Cale, Nick and Bashar have managed to maintain a contiguous thought across two different episodes and are returning to school - for the basics of immunology. But they’re not going back as teachers, no, the boys are going undercover as a naïve B-cell and following the journey to the lymph node. Will they be shunned to the uncool table like they were in high school? Can they avoid the murderous hunger games of the dark zone. Will they switch classes or somatically hypermutate? Find out on the next episode of 21 Ju… Lymph Node Street.

TIMESTAMPS

 0:53 - Disguise 101
 5:10 - Naive B cells journey
 7:56 - Lymph node anatomy refresher
 13:31 - Activation of naive B cells
 18:50 - Class switching
 21:38 - Into the dark zone
 24:45 - Diseases at the various stages of maturation
 27:18 - Take Home Messages 

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Have you been asked to review “TLS” bloods?? Are you concerned the nursing staff are pranking you with haematology bloods that don’t include a FBC or coags? Why could you possibly want to look at something that isn’t a cell count? What crazy person decided after hours bloods needed to be collected on ICE? And WHY ?!?! Join us for an On The Wards approach to dealing with those TDS TLS SOS calls.

TIMESTAMPS:

0:56 - The team breaking stuff
3:40 - Episode overview
5:07 - Setting the scene
6:33 - The history of TLS
7:28 - (nailed it)
8:00 - Pathophysiology of TLS
10:41 - Mechanisms of renal injury in TLS
11:39 - Clinical consequences of TLS
12:46 - Diagnostic criteria in TLS
15:10 - Clinical TLS vs lab TLS
15:35 - Grading TLS
16:55 - Other clues of TLS
18:09 - Who is at risk of TLS?
23:15 - Prevention of TLS
24:27 - Allopurinol
26:58 - Rasburicase
33:03 - Fluids fluids fluids
33:44 - Deciding who gets prophylaxis
35:50 - What ARE TLS bloods?
36:31 - What to do with a TLS on the ward
40:05 - Take home messages

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au