Bloody Minded

Join the boys as they frollickular through the molecular and macro-cular particulars of follicular lymphoma this week. While you're at it, please sign our petition to allow Bashar back into the aquarium and take a gander at Cale's tiny hands.

Timestamps

00:52 - Bashar is banned from the Aquarium a second time
02:13 - Follicular Lymphoma Overview
06:07 - Pathophysiology of FL
09:50 - Follicular Lymphoma In Situ (Old Name)
11:54 - Clinical & Morphology
17:24 - Identifying FL in the Lab
20:08 - Staging & Workup
23:07 - Prognostication
25:56 - To treat or not to treat?
29:31 - Treating Upfront
33:59 - Treating Relapse
37:43 - Transformation
41:12 - Summary

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Why do haematologists get excited over smudges on a film? What is the deal with that whole IGHV situation? Why is Bashar no longer welcome at the zoo? Join us as we find the answers to these common haematology questions and more in a foray into Chronic Lymphocytic Leukaemia!

TIMESTAMPS

0:55 - No animals were harmed in the making of this bit
 4:13 - Epidemiology of CLL
 5:56 - Pathophysiology of CLL
 11:42 - MBL
 12:36 - SLL
 15:54 - Clinical features of CLL
 18:18 - Lab features of CLL
 20:50 - Flow cytometry for CLL
 23:46 - Staging of CLL
 25:38 - Prognostication of CLL
 27:38 - Indications for treatment in CLL
 31:04 - Treatment approaches for CLL
 41:53 - Response assessment in CLL
 42:49 - Richter's transformation
 44:47 - Take Home Messages

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Welcome to the Land of the Lymphoid. Eighty-odd subtypes, one grid. Help us break our cellular pathways and journey further into our lymphoid season as we ask the only two questions that matter - B or T, fast or slow, forget the platypuses - and build the framework we'll be filling in for the rest of the series. Bring a hat, the savannah is hot. 

0:52 - Lymphoid Planet
2:50 - Leukaemia vs Lymphoma
4:51 - Two Questions & A Recap
8:49 - Identifying a Cell
16:22 - Indolent vs Aggressive (and Super-Aggressive)
22:37 - Indolent B-Cell
23:21 - Aggressive B-Cell
25:27 - Indolent T-Cell
25:44 - Aggressive T-Cell
27:42 - Wait... what about Hodgkins
31:28 - A Framework
32:21 - General Lymphoma Workup
38:19 - Staging
40:12 - Review

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

For the first time, Cale, Nick and Bashar have managed to maintain a contiguous thought across two different episodes and are returning to school - for the basics of immunology. But they’re not going back as teachers, no, the boys are going undercover as a naïve B-cell and following the journey to the lymph node. Will they be shunned to the uncool table like they were in high school? Can they avoid the murderous hunger games of the dark zone. Will they switch classes or somatically hypermutate? Find out on the next episode of 21 Ju… Lymph Node Street.

TIMESTAMPS

 0:53 - Disguise 101
 5:10 - Naive B cells journey
 7:56 - Lymph node anatomy refresher
 13:31 - Activation of naive B cells
 18:50 - Class switching
 21:38 - Into the dark zone
 24:45 - Diseases at the various stages of maturation
 27:18 - Take Home Messages 

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Have you been asked to review “TLS” bloods?? Are you concerned the nursing staff are pranking you with haematology bloods that don’t include a FBC or coags? Why could you possibly want to look at something that isn’t a cell count? What crazy person decided after hours bloods needed to be collected on ICE? And WHY ?!?! Join us for an On The Wards approach to dealing with those TDS TLS SOS calls.

TIMESTAMPS:

0:56 - The team breaking stuff
3:40 - Episode overview
5:07 - Setting the scene
6:33 - The history of TLS
7:28 - (nailed it)
8:00 - Pathophysiology of TLS
10:41 - Mechanisms of renal injury in TLS
11:39 - Clinical consequences of TLS
12:46 - Diagnostic criteria in TLS
15:10 - Clinical TLS vs lab TLS
15:35 - Grading TLS
16:55 - Other clues of TLS
18:09 - Who is at risk of TLS?
23:15 - Prevention of TLS
24:27 - Allopurinol
26:58 - Rasburicase
33:03 - Fluids fluids fluids
33:44 - Deciding who gets prophylaxis
35:50 - What ARE TLS bloods?
36:31 - What to do with a TLS on the ward
40:05 - Take home messages

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

It’s the heaviest matter of haematology as we look at the role of heavy metals in our favourite metalloenzymes. What - you don’t have a favourite metalloenzyme?  But nothing else matters?! Anyway, this is no esoteric surgical content, join us as Nick, Cale and Bashar get comfy with the weirder parts of the periodic table and how they apply to less common deficiencies or toxicities in haematology. Look we’ll be honest with you - this is pretty low yield listening but it was fun, and really isn’t that point at the end of the day. 

TIMESTAMPS

0:55 - Wacken Open Air or Bloody Minded?
3:58 - Molybdenum ft. Black Eyed Peas
11:07 - Copper ft. Calf Livers
14:41 - Zinc ft. Dentures
18:35 - Cobalt - ft. Goblins and Beer
22:40 - Lead ft. Basophilic Stippling
26:13 - Aluminium ft. Pronunciation Issues
28:29 - Take Home Messages

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

Is it a giant Cthulu-esque sea monster? Is it an excellent Australian parody breakfast show? No - it’s everyone’s favourite (well everyone who counts) coagulation related Vitamin - Vitamin K! Where does it come from? Why is it so hard to find on the eMR when you want to prescribe it and what is it doing under phytomenadione? Can we test for it? After listening to Nick, Cale and Bashar wax lyrical about carboxylation for half an hour you’ll be ready to vitamin K-nock yourself out.

TIMESTAMPS

0:53 - Birdsong
3:54 - The history of Vitamin K
10:02 - Types of Vit K
12:02 - K1 + K2
13:16 - K3 + K4
14:18 - K1-4 without the possession
15:46 - What does Vit K actually do?
19:37 - Dietary sources of Vit K
23:20 - Vit K Absorption Pathway
28:00 - Vit K + Gamma glutamyl carboxylase
33:20 - Practical aspects of Vit K replacement
38:48 - Take Home Messages

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Four humours in balance, the ancients decreed -
so open a vein, let the bad blood be freed.
From Galen to Harvey, from humours to genes, 
From black bile and phlegm to the things on our screens.
From PML::RARA to blood counts okay 
Let’s celebrate our specialty - we’ve come a damn long way

Join us as we travel from the first man to see a red cell, to the first to give people arsenic on purpose who was actually well-intentioned! Pour one out for Galen who was confidently incorrect for fifteen centuries but everyone just went with it anyway because it seemed pretty good at the time. We interrupt your scheduled haematinic programming for a historical grab bag and some chat about the podcast as we celebrate 100 episodes and still going strong. 

TIMESTAMPS

1:49 - Sappy Stuff
7:15 - In the Beginning
9:52 - Leeches
12:57 - Harvey
14:43 - Microscopes
16:08 - Leukaemia
18:11 - Transfusion
20:30 - Anticoagulants
22:55 - Molecular
27:23 - Chemo
29:34 - Transplant
31:07 - Coags
33:07 - CAR-T
35:11 - Wrapup

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Two vitamins survived the great B-numbering cull to become the tests we order most and trust least. Meet the 80% of your B12 result your cells can't touch, and the antibody that sabotages the very test built to catch it. Join the Bloody Minded Crew as we come to the lab for a second time this season to learn how B12 and folate assays are performed. 

TIMESTAMPS

0:55 - The boys check out a new lab
 2:25 - Episode overview
 3:43 - Sample requirements
 4:12 - B12 refresher
 6:03 - Total B12 assays
 9:36 - Caveats in interpretation
 14:00 - Active B12
 15:59 - MMA and Homocysteine
 18:13 - Folate testing
 22:18 - Take home messages

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Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au

‘This bad boy can fit so much iron in it’ he said slapping the roof of a badly photoshopped molecule of apoferritin superimposed on a car. Is too much ferritin bad for you? Of course it is - too much is precisely the quantity that is in excess. But most of the time hyperferritinaemia has nothing to do with iron overload. Strap in to your 1992 Honda Civic as the Bloody Minded Crew learn all about ferritin, and why most of the time too much of it has nothing to do with your iron levels at all. Also join Cale specifically as he continues his vendetta against hepatology and their referrals. 

Timestamps

0:59 - Bashar visits the salon
2:03 - Hyperferritinaemia overview
3:13 - Ferritin vs Iron Overload
6:08 - Signs and Symptoms associated with Hyperferritinaemia
10:50 - Causes of Hyperferritinaemia w/o Iron Overload
16:59 - Hyperferritinaemia w/ Iron Overload
21:30 - Chelation
22:43 - Erythoferrone
24:16 - Summary

Support the show

Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au