BMJ talk medicine

In this podcast, James Cave (Editor-in-Chief) and David Phizackerley (Deputy Editor) talk about the April 2023 issue of DTB. They discuss evidence around morning and evening doses of antihypertensive medication (https://dtb.bmj.com/content/61/4/50). They review a study that analysed health technology assessment decisions made in Australia, Canada and England (https://dtb.bmj.com/content/61/4/51) and also talk about managing skin conditions in women who are planning pregnancy or who are pregnant (https://dtb.bmj.com/content/61/4/55). They begin by responding to a listener's letter about last month's podcast.

The Prescribing for pregnancy series of articles can be found here: https://dtb.bmj.com/pages/prescribing-for-pregnancy-series/

In this episode of the IJGC podcast, Editor-in-Chief, Dr. Pedro Ramirez, is joined by Dr. Giuseppe Caruso and Prof. Nicoletta Colombo to discuss updates on PARPi in ovarian cancer. Dr. Caruso is a fifth-year resident in Obstetrics and Gynecology and a first-year fellow of the PhD in “Network Oncology and Precision Medicine” at the Sapienza University of Rome in Italy. Over the past year, he has been attending the Department of Gynecologic Oncology at the European Institution of Oncology (Milan) and had the huge opportunity to follow the clinical, surgical and research activities of an international center of excellence, under the mentorship of Prof. Nicoletta Colombo and Prof. Giovanni D. Aletti. His main interest areas are gynecologic oncology, personalized oncology, clinical research, and medical writing.

Prof. Nicoletta Colombo is Chair of Gynecology Program and Director of the Ovarian Cancer Centre at the European Institute of Oncology in Milan. Principal investigators of several international clinical trials and author of several publications, she was President of ESGO and Chair of the ESMO-ESGO-ESTRO Consensus Conference in endometrial cancer (2015) and the ESMO-ESGO Consensus Conference in ovarian Cancer (2018). In 2020, Prof. Colombo received the IGCS Lifetime Achievement Award in recognition of her work in gynecological oncology.

Highlights:

- PARPi should be preferred in the upfront setting for both efficacy and safety reasons.

- Mutational status and platinum response are key factors for personalizing the maintenance treatment.

- Identifying better predictors of resistance to platinum and PARPi is an unmet need.

- PARPi combinations could become a strategy for overcoming PARPi resistance.

- The best treatment algorithm after PARPi progression needs prospective validation.

A patient and their family will often ask the most sensible, thoughtful questions and we’ll head to the evidence to find that research doesn’t quite fit the bill. We discuss this in both the abstract ‘what’s the methodological issues here’ bit of Achimedes (https://adc.bmj.com/content/108/4/323.2) and bring it to life via our case of the specialist core exercises system (https://adc.bmj.com/content/108/4/323.1). Have a listen and find out more.

We would love for you to be involved in Archi [adc.bmj.com/pages/authors/#archimedes] - just ask the questions that your patients are offering you.

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In this month’s Talk Evidence, Helen Macdonald, Juan Franco and Joseph Ross are back to talk us through some of the latest research,

They’ll talk about pay-for-perfomance schemes, and whether the data they routinely collect is measuring outcomes or tickboxes. They’ll also talk about a new analysis published on bmj.com which suggests ways in which that data could be better.

We’re also by Huseyin Naci, associate professor of health policy at the London School of Economics and Political Science, who will tell us about proposed changes to drug regulation in the UK - and we discuss research which has linked speedier regulatory approval to more adverse advents in post marketing studies.

Finally, we talk about point of care apps. The availability of medical information in the clinic has changed practice, but how good is that information? We hear about research which has evaluated those point of care apps (including BMJ’s Best Practice app) and rates them against different criteria.

Reading list

Estimated impact from the withdrawal of primary care financial incentives on selected indicators of quality of care in Scotland

https://www.bmj.com/content/380/bmj-2022-072098

How can we improve the quality of data collected in general practice?

https://www.bmj.com/content/380/bmj-2022-071950#

UK to give “near automatic sign off” for treatments approved by “trusted” regulators

https://www.bmj.com/content/380/bmj.p633

Smartphone apps for point-of-care information summaries

https://ebm.bmj.com/content/early/2023/03/14/bmjebm-2022-112146

A summary of some of the best paper we published in the April 2023 issue of the Emergency Medicine Journal. Rick and Sarah talk through topics including the impact of emergency physician gender on the outcomes of patients with early pregnancy loss; major trauma centre care for patients with low velocity trauma; the development of a new checklist for emergency paediatric intubation; the effect of head-up position on intubation success in the Emergency Department; and spiking by injection in the ED. One great feature of this month's papers is that there is so much that's immediately relevant to our clinical practice.

Read the highlights: https://emj.bmj.com/content/40/4/239

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Thank you for listening!

In this podcast, JNIS Editor-in-Chief, Dr. Felipe C. Albuquerque, speaks with Mariam Kyarunts(1) and Charlotte Michaelcheck(2), contributing authors to the recently published article "Gender disparities in industry compensation and research payments among neurointerventional surgeons in the USA" - https://jnis.bmj.com/content/early/2023/01/23/jnis-2022-019921

This paper is free-to-access for a month following the publication of this podcast.

Please subscribe to the JNIS Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest episodes. Also, please consider leaving us a review or a comment on the JNIS Podcast iTunes page: https://podcasts.apple.com/gb/podcast/jnis-podcast/id942473767

Thank you for listening!

This episode was edited by Brian O'Toole.

(1)Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA

(2)Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA

From the moment you start medical school, you’re asked the same question - ‘what kind of doctor are you going to be?’. Whilst some know from the very beginning that they’re going to be a surgeon or a paediatrician or a GP, others have no idea.

The reality of choosing a specialty can be really difficult. In this episode, we talk about the common worries that medical students or junior doctors might have when it comes to choosing a specialty. We’ll also discuss some steps we can take to make that process a little easier.

Expert guests:

Heather Samuel is a professionally qualified careers adviser with over 30 years experience, spending the last 15 years specialising in working with doctors from F1 to CCT and beyond. She now works on a freelance basis for the NHS and with schools.

Check us out on social media:

Twitter: https://twitter.com/BMJStudent

Instagram: https://www.instagram.com/bmj_student/

Facebook: https://www.facebook.com/BMJStudent/

This podcast is produced and edited by Dom Byrne and Duncan Jarvies.

Dr Philip Smith, Deputy Editor of FG and Social Media Associate Editor and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Dr Simon Everett, Consultant Gastroenterologist at Leeds Teaching Hospitals NHS Trust, Leeds, UK and BSG ERCP and EUS Quality improvement Lead, on the paper 'Individualised consent for endoscopy: update on the 2016 BSG guidelines’ published online in Frontline Gastroenterology in February 2023: https://fg.bmj.com/content/early/2023/02/07/flgastro-2022-102353

Listen to our regular podcasts and subscribe in Apple Podcasts, Google Podcasts, Stitcher and Spotify. If you enjoy our podcast, please rate us on your chosen platform, and leave us a review on the Frontline Gastroenterology Podcast page on iTunes: https://podcasts.apple.com/gb/podcast/fg-podcast/id942944229

Dr Philip Smith, Digital and Education Editor of Gut and Honorary Consultant Gastroenterologist at the Royal Liverpool Hospital, Liverpool, UK interviews Professor Tine Jess, from the Center for Molecular Prediction of Inflammatory Bowel Disease, Department of Clinical Medicine, and Department of Gastroenterology and Hepatology, Aalborg University, Aalborg, Denmark, and Dr Adam S Faye, from the Department of Medicine and Population Health, New York University Langone Health, New York, USA, on the paper 'Antibiotic use as a risk factor for inflammatory bowel disease across the ages: a population-based cohort study' published in paper copy in Gut in April 2023 and published online: https://gut.bmj.com/content/72/4/663

Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Age-related macular degeneration is the third most common cause of visual impairment worldwide. The main risk is advanced disease and resultant visual loss.

Prompt diagnosis and treatment can make a big difference to the outcome - so it is vital that we get the diagnosis and management of this condition right.

In this BMJ Best Practice podcast on macular degeneration, Kieran Walsh talks with Dr. Sajjad Mahmood, Consultant Ophthalmic Surgeon, Medical Retina Specialist, and Honorary Clinical Lecturer at the University of Manchester.

For more on age-related macular degeneration, visit BMJ Best Practice: bestpractice.bmj.com/topics/en-gb/554

Competing interests: SM has done consultancy work and received honoraria for lecturing and travel from Bayer Pharmaceuticals and Novartis. He has also been a principal investigator for clinical trials on behalf of Bayer, Novartis, and Roche.