Today we will cover an overview of traumatic brain injury (TBI) and spinal cord injury (SCI), focusing on their pathophysiology, clinical presentation, and management. It covers the mechanisms of injury, the resulting neurological complications, and the various diagnostic and treatment approaches for both conditions. We delve into the anatomy and physiology of the brain and spinal cord, explaining key concepts like intracranial pressure, cerebral perfusion pressure, and the Monroe-Kellie hypothesis.