Brain Health and Healing

Why folate (folic acid) can have opposite effects on mood. How It can worsen undemethylated depression, by reducing serotonin, dopamine and norepinephrine in the synapse. How, conversely, it can be antidepressant for people who do not create enough antidepressant neurotransmitters. Also discusses how folate can, in some cases, help counter voices and mania.

Reference books
Walsh WJ, Nutrient Power
Edelman E, Natural Healing for Bipolar Disorder/Schizophrenia

#Folate, #depression, #mania, #folate depression, #folate mania, #folate bipolar, #folic acid, #BH4, #biopterin, #methyl-folate, #OCD, #overstimulation, #voices, #paranoia

Brain undermethylation is frequently associated with chronic severe depression and schizoaffective. It is also common in autism, OCD, and learning and behavior disorders.  This podcast describes the means by which methylation regulates the availability of serotonin, dopamine and norepinephrine to counter depression. We also discuss effects on mental and physical health, and look at methionine, SAMe, methyl-B12, and other nutrients which support methylation.

Studies and Books
Pfeiffer: Histamine in schizophrenia
Jaffe/Kruesi: Biotypes
Walsh book: Nutrient Power
Edelman book: Natural Healing for Bipolar Disorder

#brain undermethylation, #methylation, #histadelia, #depression, #schizoaffective, #OCD #autism, #serotonin, #dopamine, #norepinephrine, #SAMe, #methionine, #methyl-B12, #severe depression, #obsessions, #compuslsions

Brief overview of the importance of B6 to cognition, mood, and neuroprotection. Discusses dopamine, norepinephrine, acetylcholine, GABA, taurine, and MAO.  Looks at effects on depression anxiety, learning, autism, psychosis,  etc.
Some of the studies:
Learning disorders
Anxiety depression, epilepsy
Vitamin B6 info
Rimland on autism
#vitamin B6, #P5P, #depression, #anxiety, #learning disorders, #autism, #childhood psychosis, #pyroluria, #pyrrole disorder, #serotonin 

Copper and zinc exist in a dynamic balance. High copper with low zinc is overstimulating and can contribute to symptoms in anxiety, paranoia, violence, hyperactivity, schizophrenia, bipolar, autism and insomnia.  Discusses the effects of zinc and copper on body and brain.
Studies:
Copper info
Zinc and wound healing
Metal metabolism enzyme
Walsh on copper in autism, postpartum issues, and violence.

#copper, #copper zinc ratio, #bipolar, #schizophrenia, #violence, #insomnia, #anxiety, #mania, #paranoia, #autism, #anxiety, #hyperactivity, #copper anxiety,  #copper autism, #copper schizophrenia, #cooper violence, #copper mania, #zinc anxiety, #zinc paranoia, #zinc insomnia, #brain health and healing podcast

We talk here about a major stress disorder, pyroluria, that occurs across the gamut of mental health conditions: schizophrenia, bipolar, anxiety, panic, PTSD, learning and behavior disorders, etc. People with pyrrole disorder react intensely to stress. The good news is it’s very responsive to nutrient treatment, particularly to zinc and B6 (or P5P), which are constantly depleted by pyrroles. (But similarly, people can go downhill fast if nutrients are discontinued.) This podcast looks at signs, symptoms, and nutrients.

Definitions useful for this episode:
Pyrrole - a natural biochemical used in forming the hemoglobin in red blood cells.
Pyrrole disorder - a condition in which excess of certain pyrroles removes significant quantities of B6 and zinc, increasing sensitivity to stress, and leading to adverse mental and physical reactions.
P5P (pyridoxal-5-phosphate) - a more potent form of B6.

A couple of good articles on pyroluria:
https://pubmed.ncbi.nlm.nih.gov/18383989/
https://pubmed.ncbi.nlm.nih.gov/18517107/

#BrainHealthAndHealing, #PyrroleDisorder, #pyroluria, #PTSD, #anxiety, #stress, #mood, #RapidCyclingBipolar, #schizophrenia, #zinc, #B6, #P5P, #IntegrativePsychiatry, #OrthomolecularPsychiatry

Explores the profound influence of sunlight on mood. Also goes into the effects of light dark cycles on hormone rhythms, on serotonin and melatonin production, and on cortisol and sleep interactions. And how these changes further alter mood.

See also:
Vitamin D history.
https://www.sciencedirect.com/science/article/abs/pii/S1876201816301757
Two studies on predominance of mania inequatorial regions:
https://www.researchgate.net/publication/10882671_Predominant_Polarity_of_Bipolar_Patients_in_Israel
https://www.sciencedirect.com/science/article/abs/pii/S1876201816301757

A short segment on neural communication. A nerve cell is like a tree with a filament-like trunk, and branches on either end. Messages go to receptors on dendrites (the initial branches). Second messengers transfer information through to the nerve cell body, which computes whether to send it on through the neural axon. Sequential interchange of sodium and potassium ions creates an electrical potential down the axon to the terminal branches. Here calcium smashes vesicles filled with neurotransmitter against the terminal branch membrane, spilling neurotransmitter into the synapse. Neurotransmitter stimulates receptors on one or many other nerve cells. Reuptake transporters take neurotransmitter back up into the sending neuron and so mediate the time in which the neurotransmitter is available to send messages.
Videos on neurotransmission: https://duckduckgo.com/?q=neural+communication+video&t=ffab&iax=videos&iai=https%3A%2F%2Fwww.youtube.com%2Fwatch%3Fv%3DWhowH0kb7n0&ia=videos
#brainhealthandhealing, #neurotransmission, #neurotransmitter #reuptaketransporter, #axon, #synapse, #action potential, #neuralreceptor, #dendrites #neuralcommunication

Biochemical individuality. In 1957, Dr Roger Williams, with his book, Biochemical Individuality, brought attention to the concept that each person is biochemically unique. Some people are born with 3 kidneys or a heart on the “wrong” side of the body. Some have thyroid glands that can get so overactive under stress, as to trigger mania. Or overproducing adrenals that foster mania or psychosis. Or poor function of certain enzymes, like NAD, a key to brain metabolism, underactivity of which may lead to voices, dementia or depression. This uniqueness is one reason why nothing we say here should be interpreted as a prescription: treatment must be tailored to individual requirements. What we are doing here is teaching, so a person can work with their physician to determine what nutrients are best for them at any given time.
Book: Biochemical Individuality by Roger Williams: 

The brain is made from, and runs on, nutrients. Enzymes, proteins, neurotransmitters, hormones, and all brain cells are made of nutrients. Nutrients protect the brain from oxidative stress and toxicity. Nutrients (and environment) determine genetic expression, regulating stimulating and inhibitory brain activity and other brain processes.  All of which underlies the effectiveness of nutrients in schizophrenia, as per the outcomes of Dr Carl Pfeiffer and Dr Abram Hoffer; and in bipolar, autism, learning disorders, violence, and other mental health conditions, as per the extensive database of Dr William Walsh.
https://www.walshinstitute.org/uploads/1/7/9/9/17997321/293801829-pyrrole-and-methyl.pdf

The foundations of orthomolecular psychiatry. Nutrient treatment of the anxiety, depression and psychosis in scurvy and pellagra. Dr Abram Hoffer’s niacin and vitamin C megavitamin therapy for schizophrenia. Dr Carl Pfeiffer’s histamine axis biotypes. The research on pyrrole disorder.  Dr William Walsh’s methylation imbalances and applications to bipolar, autism, violence, etc.  Nutritional psychiatry continues to evolve through the work of many noted researchers. 
Suggested books: Adventures in Psychiatry by Abram Hoffer
https://www.orthomolecular.org/library/jom/1974/pdf/1974-v03n04-p223.pdf