When Hannah was a baby, she was diagnosed with a rare eye disease that usually leaves patients completely blind. But Hannah’s story turned out differently thanks to an incredible gene therapy developed at Children’s Hospital of Philadelphia and Penn Medicine. In this episode of The Breakthrough Chronicles, 11-year-old Hannah and her mom, Amy, share their family’s inspiring story with Madeline – and talk about how this breakthrough treatment changed Hannah’s life.

Emily was just 6 years old when she received CAR T cell immunotherapy for relapsed leukemia at Children’s Hospital of Philadelphia. Emily was the very first child to receive this groundbreaking treatment – and in 2022, she celebrated 10 years cancer free. In this episode of The Breakthrough Chronicles, Emily and her father, Tom, speak with Madeline about what it’s like to be part of a medical breakthrough – and share what Emily’s life is like today.

When Addy and Lily Altobelli were born in CHOP’s Garbose Family Special Delivery Unit, they needed highly specialized care because they were conjoined – their bodies were connected at the chest wall, diaphragm and liver. After spending almost a year in intensive care at CHOP, they were separated during a 10-hour surgery – and today, they’re thriving. Their parents, Dom and Maggie, join Madeline to share their daughters’ incredible story.

Incredible stories like Addy and Lily's would not be possible without continued advancement by dedicated researchers and clinicians at CHOP and generous philanthropic support from partners like you. Click here to donate.

Hematologist and oncologist Denise Adams, MD, specializes in treating vascular anomalies, which occur when arteries, capillaries, veins or lymphatic vessels fail to develop correctly. She joins Madeline to discuss what the future holds for her field – and the surprising advice that inspired her to move forward in her career.  

Our mitochondria make the energy that keeps us alive. Geneticist Marni Falk, MD, joins Madeline to discuss what happens when our mitochondria don’t work properly, the breakthroughs she and her team are making for patients with mitochondrial disease, and the importance of having a strong vision for your career.

While growing up in Panama, Diva DeLeón-Crutchlow, MD, MSCE, always wanted to understand how things worked. She speaks to Madeline about how her curiosity led her to pursue a career in medicine – and the work she’s doing today to develop new treatments for congenital hyperinsulinism and diabetes.

Pediatric and fetal surgeon Holly Hedrick, MD, has made life-changing breakthroughs for children with congenital diaphragmatic hernia and other rare birth defects. She joins Madeline to talk about the advice her mentors shared with her along the way – and the children who continue to inspire her every day.

In 2021, Susan Furth, MD, PhD, was named CHOP’s Chief Scientific Officer, becoming the first woman in CHOP’s 166-year history to hold this prestigious role. She joins Madeline to discuss CHOP’s trailblazing Frontier Programs, the importance of mentorship, and what the future holds for research at CHOP.

The team at CHOP’s Cardiac Center has been making life-changing breakthroughs for children for many years. The center’s co-director, pediatric heart surgeon Dr. Jonathan Chen, joins Madeline to discuss his team’s latest innovations – and to share his vision for the future of pediatric cardiac care.

This fall, CHOP will celebrate an important milestone: the grand opening of its new hospital in King of Prussia, Pa. Dr. Jan Boswinkel, the Chief Operating Officer of the King of Prussia hospital, joins Madeline to talk about what this milestone means for patients, families and the community – and shares what it’s like to build a new hospital from the ground up.