Breakpoints

Breakpoints

By Society of Infectious Diseases PharmacistsScienceEducation
Download on the App Store

Breakpoints episodes

  • #50 – Moving to the Algo-rhythm of IDWeek 2021: Highlights in SoMe and ASP
    Episode Notes

    Drs. Timothy Gauthier (@IDstewardship) and Jillian Hayes (@thejillianhayes) join Dr. Zahra Kassamali Escobar (@zkePharmD) to recap some IDWeek 2021 highlights on social media and antimicrobial stewardship.

    The views and opinions expressed in this podcast are that of the speakers and do not necessarily reflect those of any past, current, or potential future employer.

    Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About

    Twitter: @SIDPharm (https://twitter.com/SIDPharm)
    Instagram: @SIDPharm (https://www.instagram.com/sidpharm/)
    Facebook: https://www.facebook.com/sidprx
    LinkedIn: https://www.linkedin.com/company/sidp/ 

    References:

    1. Vosoughi S et al. The spread of true and false news online. Science 2018;359:1146-1151. doi: 10.1126/science.aap9559.
    2. Solis Arce JS et al. COVID-19 vaccine acceptance and hesitancy in low-and middle-income countries. Nature Medicine 2021;27:1385-1394. doi: 10.1038/s41591-021-01454-y.
    3. Metlay JP et al. Tensions in antibiotic prescribing: pitting social concerns against the interests of individual patients. J Gen Intern Med 2002;17(2):87-94. doi: 10.1046/j.1525-1497.2002.10711.x.
    4. Wang et al. Development of Multifaceted Antimicrobial Stewardship Curriculum for Undergraduate Medical Education: The Antibiotic Stewardship, Safety, utilization, Resistance, and Evaluation (ASSURE) Elective. _Open Forum Infect Dis _2021;8(6): ofab231. https://doi.org/10.1093/ofid/ofab231.
    5. Charani E et al. Understanding the Determinants of Antimicrobial Prescribing Within Hospitals: The Role of “Prescribing Etiquette.” Clin Infect Dis 2013;57(2):188-196. doi: 10.1093/cid/cit212.
    6. Lines TH et al. Driving antimicrobial use improvement: attitudes of providers of adult hospital care on optimal attribution and feedback. Infect Control Hosp Epidemiol 2018;39(8):983-985. doi: 10.1017/ice.2018.113.
    7. Teshome BF et al. Duration of Exposure to Antipseudomonal B-Lactam Antibiotics in the Critically Ill and Development of New Resistance. Pharmacotherapy 2019;39(3):261-270. doi: 10.1002/phar.2201.
    8. Teshome BF et al. Evaluation of a ceiling effect on the association of new resistance development to antipseudomonal beta-lactam exposure in the critically ill. Infect Control Hosp Epidemiol 2020;41(4):484-485.
    9. Leone M et al. De-escalation versus continuation of empirical antimicrobial treatment in severe sepsis: a multicenter non-blinded randomized noninferiority trial. Intensive Care Med 2014;40: 1399-1408. doi: 10.1007/s00134-014-3411-8.
    10. Stevens V et al. Cumulative antibiotic exposures over time and the risk of Clostridium difficile infection. Clin Infect Dis 2011;53(1):42-48. doi: 10.1093/cid/cir301.
    11. Bhalodi A et al. Impact of antimicrobial therapy on the gut microbiome. J Antimicrob Chemother 2019;74(Suppl 1):i6-i15. doi: 10.1093/jac/dky530.
      12. 1 hr 2 min
    12. #49 – A PGY-What Now? A Primer on ID Pharmacy Fellowships
      Episode Notes

      Drs. Keith Rodvold and Taylor Morrisette (@TayMorrisette) join Dr. Julie Ann Justo (@julie_justo) to discuss ID pharmacy fellowships, their pros and cons compared to other post-graduate training opportunities, the ID "pharmily tree," and Mai Tais.

      Find more information on ID pharmacy fellowships available in the United States here:

      -SIDP Fellowship Listings
      -ACCP Directory of Residencies, Fellowships, and Graduate Training Programs

      Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About

      Twitter: @SIDPharm (https://twitter.com/SIDPharm)
      Instagram: @SIDPharm (https://www.instagram.com/sidpharm/)
      Facebook: https://www.facebook.com/sidprx
      LinkedIn: https://www.linkedin.com/company/sidp/

      52 min
    13. #48 – Aligning Goals: Antibiotics in End of Life Care

      Drs. Molly Sinert and Jon Furuno join Dr. David Ha (@DHpharmd) to discuss the prevalence of antibiotic use and its harms and benefits in reducing suffering and providing comfort during end-of-life care.

      Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About

      Twitter: @SIDPharm (https://twitter.com/SIDPharm)
      Instagram: @SIDPharm (https://www.instagram.com/sidpharm/)
      Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp/

      References:

      1. Sinert et al. Guidance for Safe and Appropriate Use of Antibiotics in Hospice Using a Collaborative Decision Support Tool. Accessed October 6, 2021. https://oce-ovid-com.laneproxy.stanford.edu/article/00129191-202008000-00005/HTMLA
      2. Albrecht JS, McGregor JC, Fromme EK, Bearden DT, Furuno JP. A Nationwide Analysis of Antibiotic Use in Hospice Care in the Final Week of Life. Journal of Pain and Symptom Management. 2013;46(4):483-490. doi:10.1016/j.jpainsymman.2012.09.010
      3. Furuno JP, Noble BN, Fromme EK. Should we refrain from antibiotic use in hospice patients? Expert Review of Anti-infective Therapy. 2016;14(3):277-280. doi:10.1586/14787210.2016.1128823
      4. Servid SA, Noble BN, Fromme EK, Furuno JP. Clinical Intentions of Antibiotics Prescribed Upon Discharge to Hospice Care. Journal of the American Geriatrics Society. 2018;66(3):565-569. doi:10.1111/jgs.15246
      5. Gaw CE, Hamilton KW, Gerber JS, Szymczak JE. Physician Perceptions Regarding Antimicrobial Use in End-of-Life Care. Infection Control & Hospital Epidemiology. 2018;39(4):383-390. doi:10.1017/ice.2018.6
      6. Broom J, Broom A, Good P, Lwin Z. Why is optimisation of antimicrobial use difficult at the end of life? Internal Medicine Journal. 2019;49(2):269-271. doi:10.1111/imj.14200
      7. Kwon KT. Implementation of Antimicrobial Stewardship Programs in End-of-Life Care. Infect Chemother. 2019;51(2):89-97. doi:10.3947/ic.2019.51.2.89
      8. Datta R, Topal J, McManus D, et al. Perspectives on antimicrobial use at the end of life among antibiotic stewardship programs: A survey of the Society for Healthcare Epidemiology of America Research Network. Infection Control & Hospital Epidemiology. 2019;40(9):1074-1076. doi:10.1017/ice.2019.194
      9. Lopez S, Vyas P, Malhotra P, et al. A Retrospective Study Analyzing the Lack of Symptom Benefit With Antimicrobials at the End of Life. Am J Hosp Palliat Care. 2021;38(4):391-395. doi:10.1177/1049909120951748
      10. Ito H. Antibiotics in end-of-life care: What is the driving factor? Infectious Diseases Now. Published online July 7, 2021. doi:10.1016/j.idnow.2021.07.003
      11. Kates OS, Krantz EM, Lee J, et al. Association of Physician Orders for Life-Sustaining Treatment With Inpatient Antimicrobial Use at End of Life in Patients With Cancer. Open Forum Infectious Diseases. 2021;8(8). doi:10.1093/ofid/ofab361
      12. Hickman SE, Nelson CA, Moss AH, Tolle SW, Perrin NA, Hammes BJ. The consistency between treatments provided to nursing facility residents and orders on the physician orders for life-sustaining treatment form. J Am Geriatr Soc. 2011; 59(11): 2091–2099. doi:10.1111/j.1532-5415.2011.03656.x.
      13. Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clinical Infectious Diseases, Volume 62, Issue 10, 15 May 2016, Pages e51–e77, https://doi.org/10.1093/cid/ciw118
        14. 1 hr 1 min
      15. #46 – A Nefarious Orchestra: Gram-Negative Resistance Mechanisms Part 1

        Mechanisms of antibiotic resistance help us understand and recognize antibiotic susceptibility patterns that don't make sense. Robert Bonomo and Ryan Shields (@ryankshields) join Erin McCreary (@ErinMcCreary) to discuss efflux and porin mechanisms of resistance in Gram negative bacteria and their impact on antibacterial treatment.

        Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About

        Twitter: @SIDPharm (https://twitter.com/SIDPharm)
        Instagram: @SIDPharm (https://www.instagram.com/sidpharm/)
        Facebook: https://www.facebook.com/sidprx
        LinkedIn: https://www.linkedin.com/company/sidp/

        56 min
      16. #45 – Expectation vs. Reality: An Insider look at the OVERCOME and MERINO-2 trials

        Pathogen-directed trials are among the most important trials that clinicians need to guide therapy but are also incredibly difficult to design and enroll. Rachel Britt (@RachelBPharmD) gets a behind-the-scenes interview with Adam Stewart (@adm_stewart), lead investigator of MERINO-2, and Jason Pogue (@jpogue1), lead investigator of OVERCOME. They discuss original intentions and evolving expectations to investigate optimal antibiotic therapy for multidrug resistant bacteria. Listen in for the insider analysis!

        Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About

        Twitter: @SIDPharm (https://twitter.com/SIDPharm)
        Instagram: @SIDPharm (https://www.instagram.com/sidpharm/)
        Facebook: https://www.facebook.com/sidprx
        LinkedIn: https://www.linkedin.com/company/sidp/

        42 min
      17. #44 – The VaxScene, a review of the COVID-19 vaccine landscape in the US with a focus on equitable distribution and vaccine hesitancy

        Jacinda Abdul-Mutakabbir (@jayCdoesID) and Jeannette Bouchard (@jlbouchard001) join Erin McCreary (@ErinMcCreary) to discuss COVID vaccines, including access to, confidence in, and hesitancy around them. 

         
        This episode was sponsored by an unrestricted educational grant from Janssen Therapeutics, Division of Janssen Products, LP

        References:

        1. Polack FP, Thomas SJ, Kitchin N, et al. Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine. N Engl J Med 2020;383:2603-2615.
        2. Baden LR, El Sahly HM, Essink B, et al. Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine. N Engl J Med 2021;384:403-416.
        3. Sadoff J, Gray G, Vandebosch A, et al. Safety and Efficacy of Single-Dose Ad26.COV2.S Vaccine against Covid-19. N Engl J Med 2021
        4. Rosenblum HG, Hadler SC, Moulia D, et al. Use of COVID-19 Vaccines After Reports of Adverse Events Among Adult Recipients of Janssen (Johnson & Johnson) and mRNA COVID-19 Vaccines (Pfizer-BioNTech and Moderna): Update from the Advisory Committee on Immunization Practices — United States, July 2021. MMWR Morb Mortal Wkly Rep 2021;70:1094-1099. DOI: http://dx.doi.org/10.15585/mmwr.mm7032e4external icon.
        5. Rapaka RR, Hammershaimb EA, Neuzil KM. Are some COVID vaccines better than others? Interpreting and comparing estimates of efficacy in trials of COVID-19 vaccines [published online ahead of print, 2021 Mar 6]. Clin Infect Dis. 2021;ciab213. doi:10.1093/cid/ciab213
        6. ACIP Website: https://www.cdc.gov/vaccines/acip/index.html
        7. Marcelin JR, Swartz TH, Bernice F, et al. Addressing and Inspiring Vaccine Confidence in Black, Indigenous, and People of Color (BIPOC) during the COVID-19 Pandemic. [published online ahead of print, 2021 Aug 9]. Open Forum Infect Dis. 2021. Doi: 10.1093/ofid/ofab417
        8. Abdul-Mutakabbir JC, Casey S, Jews V, et al. A three-tiered approach to address barriers to COVID-19 vaccine delivery in the Black community. Lancet Glob Health. 2021 Jun;9(6):e749-e750. doi: 10.1016/S2214-109X(21)00099-1. Epub 2021 Mar 10.

          9. Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About

          Twitter: @SIDPharm (https://twitter.com/SIDPharm)
          Instagram: @SIDPharm (https://www.instagram.com/sidpharm/)
          Facebook: https://www.facebook.com/sidprx
          LinkedIn: https://www.linkedin.com/company/sidp/

          1 hr 2 min
        9. #43 – Level Up: Implementation of Beta-lactam Therapeutic Drug Monitoring

          Erin McCreary (@erinmccreary) reviews clinical data and implementation strategies for therapeutic drug monitoring of beta-lactam antibiotics with Veena Venugopalan (@Veena_PharmD), Joseph Kuti, Jason Roberts (@jasonroberts_pk), and Marc Scheetz (@IDPharmacometrx).

          Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About

          Twitter: @SIDPharm (https://twitter.com/SIDPharm)
          Instagram: @SIDPharm (https://www.instagram.com/sidpharm/)
          Facebook: https://www.facebook.com/sidprx
          LinkedIn: https://www.linkedin.com/company/sidp/

          1 hr 3 min
        10. #42 – The Level is in the Details: Beta-lactam Therapeutic Drug Monitoring

          Erin McCreary (@erinmccreary) discusses clinical rationale behind therapeutic drug monitoring of beta-lactam antibiotics with Veena Venugopalan (@Veena_PharmD), Joseph Kuti, Jason Roberts (@jasonroberts_pk), and Marc Scheetz (IDPharmacometrx).

          For BCIDP credit, visit https://sidp.org/BCIDP

          References:

          1. https://pubmed.ncbi.nlm.nih.gov/32383061/

            2.    https://clicktime.symantec.com/3BcGw6g11AZY2rSUu7KpT1D7Vc?u=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34136822%2F3. https://pubmed.ncbi.nlm.nih.gov/33480024/

          2. https://pubmed.ncbi.nlm.nih.gov/32910809/

            Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About

            Twitter: @SIDPharm (https://twitter.com/SIDPharm)
            Instagram: @SIDPharm (https://www.instagram.com/sidpharm/)
            Facebook: https://www.facebook.com/sidprx
            LinkedIn: https://www.linkedin.com/company/sidp/

            56 min
          3. #41 – The Gray Zone: Antimicrobial Stewardship in Immunocompromised Hosts

            Promoting evidence-based antimicrobial stewardship for patients with immunocompromising conditions can be tricky when they’re often excluded from clinical studies. Dr. Zahra Kassamali Escobar (@ZKEPharmD) explores this gray zone with Dr. Catherine Liu and Dr. Justine Ross (@abella_ross)

            References:

            Fluoroquinolone Prophylaxis 

            • Bucaneve et al. Levofloxacin to prevent bacterial infection in patients with cancer and neutropenia. N Engl J Med 2005; 353:977-87. DOI: 10.1056/NEJMoa044097 
            • Cullen et al. Antibacterial prophylaxis after chemotherapy for solid tumors and lymphomas. N Engl J Med 2005; 353:988-98. DOI: 10.1056/NEJMoa050078 
            • Drayson et al. Levofloxacin prophylaxis in patients with newly diagnosed myeloma (TEAMM): a multicenter, double-blind, placebo-controlled, randomized, phase 3 trial. Lancet Oncology  2019; 20(12):1760-72. DOI: 10.1016/S1470-2045(19)30506-6
            • Satlin et al. Colonization with fluoroquinolone-resistant enterobacterales decreases the effectiveness of fluoroquinolone prophylaxis in hematopoietic cell transplant recipients. Clin Infect Dis 2021 May 6. doi: 10.1093/cid/ciab404. 

              • Antibiotic Treatment and Microbiome Implications

              • Aguilar-Guisado M, et al. Optimisation of empirical antimicrobial therapy in patients with haemotological malignancies and febrile neutropenia (How Long study): an open-label, randomized, controlled, phase 4 trial. Lancet Haematol. 2017 Dec;4(12):e573-83. doi: 10.1016/S2352-3026(17)30211-9.
              • Shono et al. Gut microbiome injury in allogeneic haematopoietic stem cell transplantation. Nat Rev Cancer. 2018;18(5):283-95. doi: 10.1038/nrc.2018.10. 
              • Weber et al. Microbiome disruption induced by early use of broad-spectrum antibiotics is an independent risk factor of outcome after allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2017;23(5):845-52. doi: 10.1016/j.bbmt.2017.02.006 
              • Pinato et al. Association of prior antibiotic treatment with survival and response to immune checkpoint inhibitor therapy in patients with cancer. JAMA Oncol. 2019;5(12):1774-78. doi:10.1001/jamaoncol.2019.2785  

                • Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About

                Twitter: @SIDPharm (https://twitter.com/SIDPharm)
                Instagram: @SIDPharm (https://www.instagram.com/sidpharm/)
                Facebook: https://www.facebook.com/sidprx
                LinkedIn: https://www.linkedin.com/company/sidp/

                1 hr

              About Breakpoints

              From the publisher's feed

              The SIDP Podcast

              More shows like Breakpoints

              NEJM This Week by NEJM Group

              NEJM This Week

              319 Listeners

              This Week in Virology by Vincent Racaniello

              This Week in Virology

              2,052 Listeners

              JAMA Clinical Reviews by JAMA Network

              JAMA Clinical Reviews

              496 Listeners

              Let's Talk ID by Infectious Diseases Society of America (IDSA)

              Let's Talk ID

              129 Listeners

              The Curbsiders Internal Medicine Podcast by The Curbsiders Internal Medicine Podcast

              The Curbsiders Internal Medicine Podcast

              3,343 Listeners

              Core IM | Internal Medicine Podcast by Core IM Team

              Core IM | Internal Medicine Podcast

              1,157 Listeners

              The Clinical Problem Solvers by The Clinical Problem Solvers

              The Clinical Problem Solvers

              520 Listeners

              Critical Care Scenarios by Brandon Oto, PA-C, FCCM and Bryan Boling, DNP, ACNP, FCCM

              Critical Care Scenarios

              256 Listeners

              Cardionerds: A Cardiology Podcast by CardioNerds

              Cardionerds: A Cardiology Podcast

              431 Listeners

              Febrile by Sara Dong

              Febrile

              190 Listeners

              ID:IOTS - Infectious Disease Insight Of Two Specialists by Infectious Disease: Insights of Two Specialists

              ID:IOTS - Infectious Disease Insight Of Two Specialists

              29 Listeners

              Infectious Disease Puscast by Vincent Racaniello

              Infectious Disease Puscast

              92 Listeners

              Critical Care Time by Critical Care Time Podcast

              Critical Care Time

              270 Listeners

              Communicable by CMI Communications

              Communicable

              4 Listeners

              Joint Approach by Musculoskeletal Infection Society

              Joint Approach

              10 Listeners