Breakpoints

Breakpoints episodes:

• 12.17.2021

  #50 – Moving to the Algo-rhythm of IDWeek 2021: Highlights in SoMe and ASP

  Episode Notes Drs. Timothy Gauthier (@IDstewardship) and Jillian Hayes (@thejillianhayes) join Dr. Zahra Kassamali Escobar (@zkePharmD) to recap some IDWeek 2021 highlights on social media and antimicrobial stewardship. The views and opinions expressed in this podcast are that of the speakers and...

  
• 12.03.2021

  #49 – A PGY-What Now? A Primer on ID Pharmacy Fellowships

  Episode Notes Drs. Keith Rodvold and Taylor Morrisette (@TayMorrisette) join Dr. Julie Ann Justo (@julie_justo) to discuss ID pharmacy fellowships, their pros and cons compared to other post-graduate training opportunities, the ID "pharmily tree," and Mai Tais. Find more information on ID...

  
• 11.19.2021

  #48 – Aligning Goals: Antibiotics in End of Life Care

  Drs. Molly Sinert and Jon Furuno join Dr. David Ha (@DHpharmd) to discuss the prevalence of antibiotic use and its harms and benefits in reducing suffering and providing comfort during end-of-life care. Learn more about the Society of Infectious Diseases...

  
• 10.29.2021

  #47 – A Nefarious Orchestra: Gram-Negative Resistance Mechanisms Part 2

  From generating 150 liters-worth of E. coli to the first X-ray crystallography of an ESBL, Drs. Robert Bonomo, Ryan Shields (@ryankshields), and Erin McCreary (@ErinMcCreary) take a deep dive into beta-lactamases like AmpCs, KPCs, and more.

  
• 10.22.2021

  #46 – A Nefarious Orchestra: Gram-Negative Resistance Mechanisms Part 1

  Mechanisms of antibiotic resistance help us understand and recognize antibiotic susceptibility patterns that don't make sense. Robert Bonomo and Ryan Shields (@ryankshields) join Erin McCreary (@ErinMcCreary) to discuss efflux and porin mechanisms of resistance in Gram negative bacteria and their...

  
• 09.24.2021

  #45 – Expectation vs. Reality: An Insider look at the OVERCOME and MERINO-2 trials

  Pathogen-directed trials are among the most important trials that clinicians need to guide therapy but are also incredibly difficult to design and enroll. Rachel Britt (@RachelBPharmD) gets a behind-the-scenes interview with Adam Stewart (@adm_stewart), lead investigator of MERINO-2, and...

  
• 09.17.2021

  #44 – The VaxScene, a review of the COVID-19 vaccine landscape in the US with a focus on equitable distribution and vaccine hesitancy

  Jacinda Abdul-Mutakabbir (@jayCdoesID) and Jeannette Bouchard (@jlbouchard001) join Erin McCreary (@ErinMcCreary) to discuss COVID vaccines, including access to, confidence in, and hesitancy around them.    This episode was sponsored by an unrestricted educational grant from Janssen Therapeutics, Division of Janssen Products, LP References: Polack...

  
• 08.27.2021

  #43 – Level Up: Implementation of Beta-lactam Therapeutic Drug Monitoring

  Erin McCreary (@erinmccreary) reviews clinical data and implementation strategies for therapeutic drug monitoring of beta-lactam antibiotics with Veena Venugopalan (@Veena_PharmD), Joseph Kuti, Jason Roberts (@jasonroberts_pk), and Marc Scheetz (@IDPharmacometrx). Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About Twitter: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm...

  
• 08.20.2021

  #42 – The Level is in the Details: Beta-lactam Therapeutic Drug Monitoring

  Erin McCreary (@erinmccreary) discusses clinical rationale behind therapeutic drug monitoring of beta-lactam antibiotics with Veena Venugopalan (@Veena_PharmD), Joseph Kuti, Jason Roberts (@jasonroberts_pk), and Marc Scheetz (IDPharmacometrx). For BCIDP credit, visit https://sidp.org/BCIDP References: https://pubmed.ncbi.nlm.nih.gov/32383061/ 2.    https://clicktime.symantec.com/3BcGw6g11AZY2rSUu7KpT1D7Vc?u=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F34136822%2F3. https://pubmed.ncbi.nlm.nih.gov/33480024/ https://pubmed.ncbi.nlm.nih.gov/32910809/ Learn more about the Society of Infectious Diseases Pharmacists:...

  
• 07.16.2021

  #41 – The Gray Zone: Antimicrobial Stewardship in Immunocompromised Hosts

  Promoting evidence-based antimicrobial stewardship for patients with immunocompromising conditions can be tricky when they’re often excluded from clinical studies. Dr. Zahra Kassamali Escobar (@ZKEPharmD) explores this gray zone with Dr. Catherine Liu and Dr. Justine Ross (@abella_ross) References: Fluoroquinolone Prophylaxis  Bucaneve et al. Levofloxacin...

  
• 06.18.2021

  #40 – Breakpoints Talks Breakpoints: Microbiology Labs and Stewardship

  In this episode, host Dr. Erin McCreary (@erinmccreary) talks all things micro labs and stewardship with Dr. Romney Humphries (@romneyinla), Dr. Mary Hutton (@m3rkat), and Dr. Joseph Lutgring. From cascading results and breakpoint changes, to making connections within and outside...

  
• 05.21.2021

  #39 – A Little More on the Littles: What Adults Should Know about ID Pediatrics

  In this rapidfire episode Dr. Erin Weslander (@littlebugdrug), Dr. Laura Bio (@StanfordPedsASP), and Dr. Diana Yu (@dyupharmd) reveal their super-secret ID toolkit to figure out dosing and approaches to treatment in pediatric patients. Learn more about the Society of Infectious Diseases...

  
• 04.23.2021

  #38 – You're KID-ding! Myths in ID Pediatrics

  Dr. Erin Weslander (@littlebugdrug), Dr. Laura Bio (@StanfordPedsASP), and Dr. Diana Yu (@dyupharmd) breakdown common myths about antimicrobials in pediatric patients. Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About Twitter: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp/

  
• 04.16.2021

  #37 – A Gab about Cab: The Short on Long-Acting Antiretrovirals for HIV

  Dr. Fidelia Bernice, Dr. Rodrigo Burgos, and Dr. Neha Pandit, join Breakpoints to discuss the first available long-acting antiretroviral agent, cabotegravir/rilpivirine. Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About Twitter: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp/

  
• 03.26.2021

  #36 – Monoclonal Antibodies: Gateway Drugs for Future Care Delivery Models

  Dr. Susan Davis (@IDPharmProf), Dr. Emily Spivak (@EmilySpivak), and Dr. Minkey Wungwattana (@minkeyw) join Dr. Erin McCreary (@ErinMcCreary) to discuss individual and shared experiences operationalizing COVID-19 monoclonal antibody therapy across their institutions and states. They tackle big and small hurdles from finding ways to...

  
• 03.19.2021

  #35 – Oral Beta-Lactams, Are We Serious?

  Dr. Jill Cowper (@jillcowper), and Dr. Jesse Sutton, join host Dr. Zahra Kassamali Escobar (@zkePharmD) to discuss the data behind use of oral beta-lactams as step-down therapy for bacteremia and other serious infections.  Learn more about the Society of Infectious Diseases...

  
• 02.19.2021

  #34 – The New Scoop on Poop: Updates in the Management of C. difficile infections

  Dr. Kevin Garey (@GareyKgarey), Dr. Kelly Reveles (@KellyReveles), Dr. Mandelin Cooper, and host Dr. Rachel Britt (@RachelBPharmD) discuss proposed updates of the IDSA-SHEA C. difficile guidelines, including: fidaxomicin over oral vancomycin as first-line therapy, the roles and logistical hurdles of fecal...

  
• 01.15.2021

  #33 – A Lung Time Coming: Controversies in Community Acquired Pneumonia

  Join Dr. Elizabeth Covington (@ewood_1875), Dr. Brandon Dionne (@BWDionne), Dr. Jason Pogue (@jpogue1), and Dr. David Ha (@DHpharmd) as they discuss new and old antibiotic therapies for community acquired pneumonia, just how typical are atypicals, what happened to HCAP, and...

  
• 12.18.2020

  #32 – Unsolicited Advice: An Honest Discussion of Burnout in Stewardship

  Join Dr. Julie Szymczak @julieszymczak, Dr. Emily Heil @emilylheil, Dr. Zahra Kassamali Escobar @zkepharmd, and Dr. Erin McCreary @erinmccreary, for a discussion on stewardship burnout—what is it, who is at risk for it, and what can we do about it? Learn...

  
• 11.20.2020

  #31 – “Mind the Gap”: Antimicrobial Stewardship at Transitions of Care

  Antimicrobial stewardship is often an inpatient effort and overlooked at transitions of care. Dr. April Dyer (@aprildyerid) and Dr. Rachel Kenney (@rkenneypharmd) share insight with host Dr. David Ha (@DHpharmD) on current practice and barriers, and strategies for pharmacists to...

  
• 10.09.2020

  #30 – Is More Better? The Role of Combination Therapy for MRSA

  Host Erin McCreary (@erinmccreary) and expert panelists Dr. Katie Barber (@IDKatieBarb), Dr. Warren Rose (@Warren_E_Rose), and Dr. Steven Tong (@syctong) discuss data from early laboratory work to randomized, clinical trials for various antibiotic combinations used in the treatment of MRSA...

  
• 09.11.2020

  #29 – What You May Have Missed Due to COVID-19: ID Literature Updates 2020 Part 2

  Erin McCreary (@erinmccreary) and Ryan Shields (@ryankshields) discuss notable infectious diseases publications from the first half of 2020. Papers discussed: 1) Van Duin D, et al. Lancet Infect Dis. 2020 Jun;20(6):731-741. doi: 10.1016/S1473-3099(19)30755-8. 2) Livermore DM, et al. Clin Infect Dis. 2020...

  
• 09.04.2020

  #28 – What You May Have Missed Due to COVID-19: ID Literature Updates 2020 Part 1

  Erin McCreary (@erinmccreary) and Ryan Shields (@ryankshields) discuss notable infectious diseases publications from the first half of 2020! Papers discussed: 1) Rybak MJ, et al. Am J Health Syst Pharm. 2020 May 19;77(11):835-864. doi: 10.1093/ajhp/zxaa036. 2) Scheetz MH. Am J Health Syst Pharm....

  
• 07.31.2020

  #27 – Expert Updates in Gram Negative Resistance: Q&A Session

  This is part 2 of a continuing education series produced in partnership with the SIDP Education Center (SIDPEC) on gram-negative bacterial resistance. It features expert speakers, Drs. Keith Kaye (@Keith_S_Kaye) and Kimberly Claeys (@ClaeysKcclaeys) and host Julie Ann Justo (@julie_justo)....

  
• 06.19.2020

  #26 – OPAT - The Final Frontier, Part 2

  Gain insight into Outpatient Parenteral Antibiotic Therapy (OPAT) practices across the country from Drs. Jessie Ortwine (@jkortwine), Monica Mahoney (@mmpharmd), Keenan Ryan (@keenanconazole), Monica Donnelley (@DonnelleyMonica), and Meera Mehta. Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About Twitter: @SIDPharm (https://twitter.com/SIDPharm) Instagram:...

  
• 06.18.2020

  #25 – Remdesivir: Ethical and Practical Considerations for Allocation, Tracking, and More

  Drs. Julie Ann Justo (@julie_justo), Erin McCreary (@erinmccreary), and Helen Newland (@helennewland) discuss ethical allocation of Emergency Use Authorization remdesivir for patients with COVID-19. Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About Twitter: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook: https://www.facebook.com/sidprx LinkedIn: https://www.linkedin.com/company/sidp/

  
• 06.12.2020

  #24 – OPAT – The Final Frontier, Part 1

  Gain insight into Outpatient Parenteral Antibiotic Therapy (OPAT) practices across the country from Drs. Jessie Ortwine (@jkortwine), Monica Mahoney (@mmpharmd), Keenan Ryan (@keenanconazole), Monica Donnelley (@DonnelleyMonica), and Meera Mehta. Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About Twitter: @SIDPharm (https://twitter.com/SIDPharm) Instagram:...

  
• 05.22.2020

  #23 – Taking a “BITE” Out of Antibiotic Prescribing: Strategies to Improve Antimicrobial Usage in Dentistry

  Dr. Katie Suda (@sudamonas) and Dr. Erinne Kennedy join Dr. Zahra Escobar (@zkepharmd) of the Breakpoints team to discuss strategies to improve antibiotic utilization and forge connections with our dental colleagues to achieve a common goal of improved patient outcomes....

  
• 05.15.2020

  #22 – Taking a “BITE” Out of Antibiotic Prescribing: The Need for Antimicrobial Stewardship in Dentistry

  Dr. Katie Suda (@sudamonas) and Dr. Erinne Kennedy join Dr. Zahra Escobar (@zkepharmd) of the Breakpoints team to discuss why dentists prescribe 1 in 10 of all antibiotics in the United States and how COVID-19 risks are being managed among...

  
• 04.27.2020

  #21 – Frontline Allies: Emergency Medicine and Critical Care Insights into COVID19

  Dr. Jenny Koehl (@jlkoehl), Dr. Karen Berger (@karenccrx), and Dr. Karen Dohr join host Erin McCreary (@erinmccreary) to discuss taking care of patients with COVID-19 in the Emergency Department and Intensive Care Unit. Listen as the team reflects on their...

  
• 04.13.2020

  #20 – What is Happening Right Now? COVID-19 Challenges and Silver Linings

  Julie Ann Justo (@julie_justo), Jason Pogue (@jpogue1), and Erin McCreary (@erinmccreary) discuss critically evaluating COVID-19 literature, staying calm in the storm, strategies for team education and communication, and the role of social media in a pandemic. Learn more about the...

  
• 02.21.2020

  #19 – Push and Pull: Combating Antibiotic Resistance from Discovery to Market Reform

  Dr. Mike Dudley (@MikeMndudley), President and CEO of Qpex Biopharma, joins Dr. Erin McCreary (@erinmccreary) to discuss the thrills and failures of antibiotic discovery and development along with the critical need for antibiotic market reform. We discuss the complexity of...

  
• 01.17.2020

  #18 – Waking the Sleeping Giant: Engaging Nurses in Antimicrobial Stewardship

  Dr. David Ha (@DHpharmd) interviews Dr. Rita Olans (@RitaOlans) and Dr. Elizabeth Monsees (@eamonsees) about the critical role nurses play in antimicrobial stewardship. They discuss how nursing practice overlaps with stewardship teams, case examples of nurse integration in stewardship in...

  
• 12.20.2019

  #17 – See C. diff: A Discussion on Patient Advocacy

  Christian John Lillis, co-founder and Executive Director of the Peggy Lillis Foundation (@peggyfund), joins Erin McCreary (@erinmccreary) to share his mother’s story and discuss opportunities and challenges for patient advocacy and antimicrobial resistance. Get involved with the Peggy Lillis Foundation: https://peggyfoundation.org/get-involved/take-action/ Learn...

  
• 11.20.2019

  #16 – 5 Ways Hospital Pharmacists Can Be Antibiotics Aware

  Dr. Susan Davis (@IDPharmProf) and Dr. Jason Pogue (@jpogue1) celebrate Antibiotic Awareness Week by discussing the 5 Ways Hospital Pharmacists Can Be Antibiotics Aware, including: verify penicillin allergy, avoid duplicate anaerobic coverage, reassess antibiotic therapy, avoid treatment of asymptomatic bacteriuria,...

  
• 11.18.2019

  #15 – CDC Core Elements of Hospital Antibiotic Stewardship Programs: 2019 Update

  Dr. Arjun Srinivasan and Dr. Melinda Neuhauser join host Dr. Erin McCreary (@erinmccreary) to discuss the updated Core Elements of Hospital Antibiotic Stewardship Programs from the Centers for Disease Control and Prevention. These updates emphasize the importance of pharmacist and...

  
• 11.08.2019

  #14 – Pumpkin-Spiced Lessons: Phages, Posters, and Paul Sax

  Erin McCreary (@erinmccreary) and Ryan Shields (@ryankshields) are joined by Dr. Paul Sax (@PaulSaxMD) to review important updates in HIV care from IDWeek 2019. They also go “rapid fire” through posters and oral abstracts presented at IDWeek 2019, nerd out...

  
• 11.08.2019

  #13 – Provocative Titles and Pro-Con Debates

  Erin McCreary (@erinmccreary) and Ryan Shields (@ryankshields) discuss the IDWeek 2019 session "We're Part of the Problem: How ID Killed Antibiotic Development' and other hot topics including pro-con debates, behavioral approaches to antimicrobial stewardship, and more. Learn more about the Society...

  
• 11.01.2019

  #12 – Late Breaker Trials and #WhyIVaccinate

  Erin McCreary (@erinmccreary) and Ryan Shields (@ryankshields) share some big announcements from IDWeek 2019 including the #WhyIVaccinate movement, data from late-breaking clinical trials, new partnerships, and more! Learn more about the Society of Infectious Diseases Pharmacists: https://sidp.org/About Twitter: @SIDPharm (https://twitter.com/SIDPharm) Instagram: @SIDPharm (https://www.instagram.com/sidpharm/) Facebook:...

  
• 11.01.2019

  #11 – Practice-changing Publications ft. David van Duin

  Erin McCreary (@erinmccreary) and Ryan Shields (@ryankshields) are joined by Dr. David van Duin (@davidvanduin) to review “Clinical Trials That Might Change Your Practice” in bacteriology, virology, and mycology from IDWeek 2019. Learn more about the Society of Infectious Diseases...

  
• 07.31.2019

  #10 – So You're an Antimicrobial Steward... Now What?

  Host Erin McCreary (@erinmccreary) and expert panelists Libby Dodds Ashley (@The_Real_LDA), Lisa Dumkow (@LisaIDpharmD), and Jamie Kisgen (@KisgenUF) share real-world experiences in order to empower new (and existing) practitioners as antimicrobial stewardship leaders. Find out how to get started based...

  
• 07.31.2019

  #9 – Show Me the Data!

  Host Erin McCreary (@erinmccreary) and expert panelists Libby Dodds Ashley (@The_Real_LDA), Lisa Dumkow (@LisaIDpharmD), and Jamie Kisgen (@KisgenUF) discuss how to market your stewardship program, with an emphasis on generating meaningful data to sustain and expand your program. Panelists share...

  
• 07.31.2019

  #8 – Stewardship is a Team Sport

  Journey with host Erin McCreary (@erinmccreary) and expert panelists Libby Dodds Ashley (@The_Real_LDA), Lisa Dumkow (@LisaIDpharmD), and Jamie Kisgen (@KisgenUF) through their lessons learned and favorite moments of their stewardship careers. We describe how to evolve as a stewardship team...

  
• 07.10.2019

  #7 – Rapid Fire Data from ECCMID 2019

  Erin McCreary (@erinmccreary) and Ryan Shields (@ryankshields) go “rapid fire” through posters and oral abstracts presented at ECCMID 2019, including: rapid diagnostics, the influence of leadership in antimicrobial stewardship, iPad technology and patient’s beliefs about antibiotics, imipenem-relebactam, cefiderocol, rezafungin, ibrexafungerp,...

  
• 07.10.2019

  #6 – Tazobactam and Tulips: Hot Topics from ECCMID 2019

  Erin McCreary (@erinmccreary) and Ryan Shields (@ryankshields) review expanded MERINO trial data including mortality by pathogen MIC, PK-PD principles, BLING III, beta-lactam therapeutic drug monitoring, linezolid dosing in renal impairment, microbiology issues, and updates from EUCAST. CORRECTION: Piperacillin-tazobactam was dosed 4.5g...

  
• 07.10.2019

  #5 – Nerding Out at ECCMID 2019

  Erin McCreary (@erinmccreary) and Ryan Shields (@ryankshields) share their secret passions and nerdiest moments from ECCMID 2019, including multi-omics data for Pseudomonas aeruginosa, the effects of chemotherapy on antimicrobial resistance, phage therapy, and more! Learn more about the Society of Infectious...

  
• 07.10.2019

  #4 – How ECCMID 2019 went viral

  Erin McCreary (@erinmccreary) and Ryan Shields (@ryankshields) review results of ASPECT-NP (Ceftolozane-tazobactam versus meropenem in patients with ventilated nosocomial pneumonia), CAMERA-2 (Combination therapy for methicillin-resistant Staphylococcus aureus bacteraemia), and Exebacase for patients with methicillin-resistant Staphylococcus aureus bacteraemia (Phase 2). Learn more...

  
• 06.26.2019

  #3 – Lessons Learned From the Front Line

  In the final part of our three part series on penicillin allergies host Jason Pogue (@jpogue1) and our expert panelists Julie Ann Justo (@julie_justo), Bruce Jones (@Bruce_M_Jones), and Mary Staicu (@marylynnstaicu) discuss important clinical pearls and lessons learned from the...

  
• 06.26.2019

  #2 – Implementing Penicillin Skin Testing

  In episode 2 host Jason Pogue (@jpogue1) and panelists Julie Ann Justo (@julie_justo), Bruce Jones (@Bruce_M_Jones), and Mary Staicu (@marylynnstaicu) discuss strategies for allergy reconciliation and implementation of penicillin skin testing. They discuss their experience with different penicillin skin testing...

  
• 06.26.2019

  #1 – Mythbusting

  In this episode host Jason Pogue (@jpogue1) discusses common misconceptions surrounding penicillin allergies, provides evidence to dispute these misgivings, and describes some of the consequences that arise from an inappropriate penicillin allergy label for a patient with expert panelists Julie...