What it's Really Like to Join a Breast Cancer Clinical Trial

Laura Yang lives in Melbourne with her husband and her 6-year-old daughter, where she enjoys listening to music, playing piano, and spending time with her loved ones.

At the end of 2022, Laura was diagnosed with breast cancer, and we spoke to her about her diagnosis and her decision to participate in a clinical trial.

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Guest: Laura Yang, Trial Participant

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Find out more: www.breastcancertrials.org.au

Metastatic Breast Cancer & the TUGETHER Clinical Trial: What You Need to Know

Maria Bodnar is a retired nurse, living in Victoria, Australia, with her husband. In 2013, Maria went in for her routine Breast Screen test, and the following day she received a call from one of the nurses asking her to come in so they could review her results, and Maria knew it was breast cancer.

Maria is a participant in the TUGETHER clinical trial, which aims to find out if adding tucatinib and pembrolizumab to the usual treatment given to people with advanced (metastatic) HER2-positive breast cancer slows down the growth of the cancer. We spoke to Maria about her diagnosis and her decision to participate in a clinical trial.

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Guest: Maria Bodnar, Trial Participant

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Find out more: www.breastcancertrials.org.au

The Patient Experience: What it's Like to Undergo a Breast MRI

As part of Breast Cancer Trials Clinical Fellowship Program, Dr Julia Matheson is working on a project that will continue research on the existing clinical trial called the Breast MRI Evaluation Study, which aims to establish when breast MRIs improve patient outcomes.

The focus of this Clinical Fellowship project will be assessing the participant experience of undergoing Magnetic Resonance Imaging (MRI) using patient-reported outcome measures (PROMs). The hypothesis is that having a breast MRI will influence patient preferences for surgery, satisfaction with decision-making, and confidence in treatment.

Find out more about the aim of this research and some of the barriers to accessing breast MRIs in this episode.

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Guest: Dr Julia Matheson

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Find out more: www.breastcancertrials.org.au

How New Breast Cancer Treatments are Impacting Tumor Biology

Breast Cancer Trials International Clinical Fellowship Support aims to financially assist promising junior researchers to gain international experience and connections.

Dr Julia Dixon-Douglas has been awarded support in the first year of the program and is heading to France to study novel therapies for breast cancer. Her research may help improve our understanding of which patients will have the greatest benefit from these treatments and how they are best administered to patients.

We asked Dr Dixon-Douglas to give an overview of her project and explain the importance of this research.

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Guest: Dr Julia Dixon-Douglas

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Metastatic Breast Cancer & the CAPTURE Clinical Trial: What You Need to Know

Sham was born in Iraq in the Middle East, but has lived in Melbourne with her parents and 2 children for the last 7 years. In 2019, Sham was diagnosed with breast cancer after noticing some pain in her right breast while at work.

She is a participant in the CAPTURE clinical trial, which aims to identify women and men with hormone-receptor-positive, metastatic breast cancer who may benefit from a novel combination of drugs that may improve progression-free survival and offer a new treatment option.

We spoke to Sham about her diagnosis and her decision to participate in a clinical trial.

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Guest: Sham, Clinical Trial Participant

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Can We Improve Breast Cancer Treatment with Fewer Side Effects?

As part of the Breast Cancer Trials clinical fellowship program, Dr Adam Ofri is working on two research projects focusing on the de-escalation of treatment. His first study, called the ‘Targeted Axillary Dissection Based Study’, aims to evaluate the armpit nodes after chemotherapy, in the hopes that fewer nodes will need to be removed during surgery, whilst still providing the same control of cancer in the armpit area.

His second study, called the ‘Decision RT Based Study’ focuses on Decision RT which is a test that is being developed to examine breast tissue from patients with DCIS to measure the benefit they would receive from radiotherapy, in the hopes of potentially avoiding patients receiving unnecessary radiotherapy. Find out more in our latest podcast episode.

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Guest: Dr Adam Ofri

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Triple-Negative Breast Cancer: What New Clinical Trials are Uncovering

Diane Barker lives in Sydney with her husband Mike, their daughter Eva, and their dog Boston. In December 2020, at just 44 years of age, Diane was diagnosed with locally advanced triple negative breast cancer.

We spoke with Diane about her diagnosis, her decision to participate in a clinical trial and the importance of supporting breast cancer clinical trials research.

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Guest: Diane Barker

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Developing Breakthrough Treatments for Invasive Lobular Carcinoma

Since 1978, Breast Cancer Trials has conducted a number of clinical trials which have changed the way we treat breast cancer, save lives and improve patient quality of life. We spoke with one of our founders, Professor Alan Coates AM, about the ANZ8101 and BIG 1-98 clinical trials, which were practice-changing research and still have relevance today.

Professor Coates discusses the changes he has seen to breast cancer treatments as a result of these trials and his excitement about the future of breast cancer research.

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Guest: Professor Alan Coates AM

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Developing Breakthrough Treatments for Invasive Lobular Carcinoma

Invasive Lobular Carcinoma (ILC) is the second most common subtype of breast cancer, with 2,400 new cases each year in Australia. Patients with ILC may have a poorer outcome over time and the cancer has a tendency to metastasize to atypical sites such as the gastrointestinal tract, gynaecological organs or orbit (eye). 

We spoke with Dr Sokolova about her research project, which will examine a new treatment approach directed at ILC.

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Guest: Dr Anna Sokolova

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How to Ease the Fear of Breast Cancer Recurrence

Approximately 70% of women experience moderate to high levels of fear of cancer recurrence (FCR) and up to 15% experience severe, disabling FCR characterised by constant, intrusive thoughts about cancer; interpretation of mild, unrelated symptoms as a sign of recurrence; a belief that cancer will return regardless of actual prognosis; and an inability to plan for the future due to cancer worry.

FCR is a routine reason for seeking professional clinical support and is associated with psychological distress, poorer social and occupational functioning, and increased health care costs.

This study will provide useful exploratory data from the PROSPECT clinical trial about the association between therapy de-escalation by omitting radiation therapy and FCR. It will also examine FCR and quality of life in women with DCIS.

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Guest: Dr Michelle Sinclair

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