Calculating an accurate renal function in patients is crucial to ensure the right dose gets to the right patient. Previous equations to estimate glomerular filtration rate depended on a race variable. However, recent data suggests this underestimates the risk of chronic kidney disease in black patients. In this episode, host Geoff Wall discusses different methods to calculate kidney function and the relationship between mortality, kidney failure, and race 

The GameChanger 

The newly proposed eGFRcr-cys equation was the most accurate in estimating the relationship of GFR to poor outcomes regardless of race. However, even with this equation, black patients were almost uniformly found to have poorer outcomes than non-black patients 

Show Segments 
00:00 – Introductions 
01:30 – Kidney Function and Kidney Disease 
03:00 – Estimating Kidney Function Based on Race 
07:44 – Cystatin C vs Creatinine Clearance  
09:57 – Association of Estimated GFR Calculated Using Race-Free Equations with Kidney Failure and Mortality by Black vs Non-Black Race   
16:11 – The GameChanger  
19:25 – Connecting to Practice 
21:16 – Closing Remarks  

Host
Geoff Wall, PharmD, BCPS, FCCP, CGP 
Professor of Pharmacy Practice, Drake University 
Internal Medicine/Critical Care, UnityPoint Health 

 
References and Resources 

Association of Estimated GFR Calculated Using Race-Free Equations with Kidney Failure and Mortality by Black vs Non-Black Race 

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CE Information
Learning Objectives 

Upon successful completion of this knowledge-based activity, participants should be able to: 

1. Describe the equation that best estimates risk of poor outcomes in patients with chronic kidney disease regardless of race 

2. List barriers to implementing cystatin-C testing in clinic laboratories 

0.05 CEU/0.5 Hr 

UAN: 0107-0000-22-280-H01-P 

Initial release date: 08/01/2022 

Expiration date: 08/01/2023 

Additional CPE and CME details can be found here. 

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