The Mississippi River is the second longest river in North America, flowing 2,350 miles from its source at Lake Itasca through the center of the continental United States to the Gulf of Mexico. The Missouri River, a tributary of the Mississippi River, is about 100 miles longer. Some describe the Mississippi River as being the third longest river system in the world, if the length of Missouri and Ohio Rivers are added to the Mississippi's main stem. But the father you get from the head, the more things are adding into it and polluting it.