🧬✨ Can we make the ageing immune system young again?

A fascinating Nature study shows that a three-part mRNA cocktail (DFI) can temporarily rejuvenate T cells in aged mice, improving responses to vaccines and cancer immunotherapy—without breaking immune tolerance. By turning the liver into a short-term factory for key immune signals (DLL1, FLT3L, IL-7), the authors demonstrate that immune ageing is modifiable, not fixed.

This elegant work—covered by Heidi Ledford in Nature—opens provocative questions about immune resilience, ageing biology, and the future of mRNA beyond vaccines. 🧠🛡️

📄 Friedrich MJ et al., Nature 2025 | News & Views: Ledford H.

🔗 doi:10.1038/s41586-025-09873-4 | doi:10.1038/d41586-025-04082-5