Matt Maiocco and Jennifer Lee Chan discuss who can replace rookie running back Isaac Guerendo's production if he can't overcome his sprained foot on a short week. Under the microscope this week, can Deebo Samuel shed the criticism and help the 49ers' offense repeat its high-octane performance vs. Chicago, or will backup Patrick Taylor Jr. emerge from anonymity as the 5th-string running back this season for San Francisco. Later, Matt and Greg Papa discuss how the 49ers' adjust their game plans and practice schedules on a short week and the possibility of linebacker Dre Greenlaw making his 2024 season debut in Week 15 vs. the Rams.

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(1:00) Must win territory, have to play desperation football
(3:30) Deebo a big topic of conversation this week, production down, but big opportunity in Week 15
(13:00)  Injury Update – Big three going into this week Guerendo, Bosa, Trent are questionable
(14:00)  Runnings back room depth chart
(17:00)  If Greenlaw returns there will be a boost in the stands and on the field
(27:00) 18 teams in the NFL run Kyle’s offense now