With Mirvat Alasnag, King Fahd Armed Forces Hospital, Jeddah - Saudi Arabia and Thomas Kümler, Steno Diabetes Center, Copenhagen, Herlev - Denmark

In this podcast, Mirvat Alasnag joins Thomas Kumler to discuss TAVI in women. References: 1. Tchetche D, Pibarot P, Bax JJ, Bonaros N, Windecker S, Dumonteil N, Nietlispach F, Messika-Zeitoun D, Pocock SJ, Berthoumieu P, Swaans MJ, Timmers L, Rudolph TK, Bleiziffer S, Leroux L, Modine T, van der Kley F, Auffret V, Tomasi J, Stastny L, Hengstenberg C, Andreas M, Leclercq F, Gandet T, Mascherbauer J, Trescher K, Prendergast B, Vasa-Nicotera M, Chieffo A, Mares J, Wesselink W, Rakova R, Kurucova J, Bramlage P, Eltchaninoff H. Transcatheter vs. surgical aortic valve replacement in women: the RHEIA trial. Eur Heart J. 2025;46:2079–88. doi:10.1093/eurheartj/ehaf133. https://academic.oup.com/eurheartj/article/46/22/2079/8103699 2. Eltchaninoff H, Bonaros N, Prendergast B, Nietlispach F, Vasa-Nicotera M, Chieffo A, Pibarot P, Bramlage P, Sykorova L, Kurucova J, Bax JJ, Windecker S, Dumonteil N, Tchetche D. Rationale and design of a prospective, randomized, controlled, multicenter study to evaluate the safety and efficacy of transcatheter heart valve replacement in female patients with severe symptomatic aortic stenosis requiring aortic valve intervention (Randomized researcH in womEn all comers wIth Aortic stenosis [RHEIA] trial). Am Heart J. 2020;228:27–35. https://www.sciencedirect.com/science/article/pii/S0002870320301964 3. Silva I, Alperi A, Hecht S, Zanuttini A, Théron A, Giuliani C, Camacho B, Dahou A, Mares J, Bax J, Bonaros N, Windecker S, Messika-Zeitoun D, Wesselink W, Rakova R, Bramlage P, Tchétché D, Eltchaninoff H, Pibarot P; RHEIA Trial Investigators. Echocardiographic results of transcatheter versus surgical aortic valve replacement in women with severe aortic stenosis: the RHEIA trial. J Am Heart Assoc. 2025. doi:10.1161/JAHA.125.047196. https://www.ahajournals.org/doi/10.1161/JAHA.125.047196 4. Eltchaninoff H, Windecker S, Mack MJ, Pibarot P, Thourani VH, Bax JJ, Cohen DJ, Bonaros N, Makkar R, Bleiziffer S, Szeto WY, Berthoumieu P, Hahn RT, Hovorka T, Mareš J, Taylor J, Tchetche D, Leon MB. Aortic Valve Replacement in Women: A Pooled Analysis of the RHEIA and PARTNER 3 Trials. JACC Cardiovasc Interv. 2025;18:1540-53. https://www.jacc.org/doi/10.1016/j.jcin.2025.03.036 5. Herrmann HC, Mehran R, Blackman DJ, Bailey S, Möllmann H, Abdel-Wahab M, Ben Ali W, Mahoney PD, Ruge H, Wood DA, Bleiziffer S, Ramlawi B, Gada H, Petronio AS, Resor CD, Merhi W, Garcia Del Blanco B, Attizzani GF, Batchelor WB, Gillam LD, Guerrero M, Rogers T, Rovin JD, Szerlip M, Whisenant B, Deeb GM, Grubb KJ, Padang R, Fan MT, Althouse AD, Tchétché D; SMART Trial Investigators. Self-expanding or balloon-expandable TAVR in patients with a small aortic annulus (SMART trial). N Engl J Med. 2024;390:1959–71. https://www.nejm.org/doi/10.1056/NEJMoa2312573 6. Herrmann HC, Tchetche D, Mehran R, et al. SMART trial 2-year outcomes: continued superior valve performance for the self-expanding TAVR system in small annulus patients. Presented at CRT 2025: 8-11 March 2025, Washington, DC, USA 7. Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, Ajmone Marsan N, Barili F, Bonaros N, Cosyns B, De Paulis R, Gamra H, Jahangiri M, Jeppsson A, Klautz RJM, Mores B, Pérez-David E, Pöss J, Prendergast BD, Rocca B, Rossello X, Suzuki M, Thiele H, Tribouilloy CM, Wojakowski W; ESC/EACTS Scientific Document Group. 2025 ESC/EACTS guidelines for the management of valvular heart disease. Eur Heart J. 2025;46:4635–736. https://academic.oup.com/eurheartj/article/46/44/4635/8234488 8. Mack MJ, Leon MB, Thourani VH, Makkar R, Kodali SK, Russo M, Kapadia SR, Malaisrie SC, Cohen DJ, Pibarot P, Leipsic J, Hahn RT, Blanke P, Williams MR, McCabe JM, Brown DL, Babaliaros V, Goldman S, Szeto WY, Genereux P, Pershad A, Pocock SJ, Alu MC, Webb JG, Smith CR; PARTNER 3 Investigators. Transcatheter aortic-valve replacement with a balloon-expandable valve in low-risk patients (PARTNER 3). N Engl J Med. 2019;380:1695–705. https://www.nejm.org/doi/10.1056/NEJMoa1814052 9. Kodali S, Williams MR, Doshi D, Hahn RT, Humphries KH, Nkomo VT, Cohen DJ, Douglas PS, Mack M, Xu K, Svensson L, Thourani VH, Tuzcu EM, Weissman NJ, Leon M, Kirtane AJ. Sex-specific differences at presentation and outcomes among patients undergoing transcatheter aortic valve replacement: a cohort study. Ann Intern Med. 2016;164:377–84. https://www.acpjournals.org/doi/10.7326/M15-0121 10. Chieffo A, Petronio AS, Mehilli J, Chandrasekhar J, Sartori S, Lefèvre T, Presbitero P, Capranzano P, Tchetche D, Iadanza A, Sardella G, Van Mieghem NM, Meliga E, Dumonteil N, Fraccaro C, Trabattoni D, Mikhail G, Sharma S, Ferrer MC, Naber C, Kievit P, Baber U, Snyder C, Sharma M, Morice MC, Mehran R; WIN-TAVI Investigators. 1-Year Clinical Outcomes in Women After Transcatheter Aortic Valve Replacement: Results From the First WIN-TAVI Registry. JACC Cardiovasc Interv. 2018;11:1–12. https://www.jacc.org/doi/10.1016/j.jcin.2017.09.034 11. Tateishi K, Hmoud H, De Gregorio I, Hastings R, De Gregorio J. The impact of gender on outcomes of transcatheter aortic valve implantation between self-expanding valve and balloon-expandable valve. Cardiovasc Revasc Med. 2024;63:38–42. https://www.sciencedirect.com/science/article/abs/pii/S1553838924000034 12. Iribarren AC, AlBadri A, Wei J, Nelson MD, Li D, Makkar R, Merz CNB. Sex differences in aortic stenosis: identification of knowledge gaps for sex-specific personalized medicine. Am Heart J Plus. 2022;21:100197. https://pmc.ncbi.nlm.nih.gov/articles/PMC9629620/ 13. Springhetti P, Abdoun K, Clavel M-A. Sex differences in aortic stenosis: from the pathophysiology to the intervention, current challenges, and future perspectives. J Clin Med. 2024;13:4237. https://www.mdpi.com/2077-0383/13/14/4237 14. Tastet L, Kwiecinski J, Pibarot P, Capoulade R, Everett RJ, Newby DE, Shen M, Guzzetti E, Arsenault M, Bédard É, Larose É, Beaudoin J, Dweck M, Clavel MA. Sex-related differences in the extent of myocardial fibrosis in patients with aortic valve stenosis. JACC Cardiovasc Imaging. 2020;13:699–711. https://www.jacc.org/doi/10.1016/j.jcmg.2019.06.014 15. Treibel TA, Kozor R, Schofield R, Benedetti G, Fontana M, Bhuva AN, Sheikh A, López B, González A, Manisty C, Lloyd G, Kellman P, Díez J, Moon JC. Reverse myocardial remodeling following valve replacement in patients with aortic stenosis. J Am Coll Cardiol. 2018;71:860–71. https://www.jacc.org/doi/10.1016/j.jacc.2017.12.035 16. Stangl V, Baldenhofer G, Laule M, Baumann G, Stangl K. Influence of sex on outcome following transcatheter aortic valve implantation (TAVI): systematic review and meta-analysis. J Interv Cardiol. 2014;27:531–9. https://onlinelibrary.wiley.com/doi/epdf/10.1111/joic.12150 17. Tribouilloy C, Bohbot Y, Rusinaru D, Belkhir K, Diouf M, Altes A, Delpierre Q, Serbout S, Kubala M, Levy F, Maréchaux S, Enriquez Sarano M. Excess mortality and undertreatment of women with severe aortic stenosis. J Am Heart Assoc. 2021;10:e018816. 18. Bienjonetti-Boudreau D, Fleury M-A, Voisine M, Paquin A, Chouinard I, Tailleur M, et al. Impact of sex on the management and outcome of aortic stenosis patients. Eur Heart J. 2021;42(27):2683–2691. https://www.ahajournals.org/doi/10.1161/JAHA.120.018816

With Tiziana Claudia Aranzulla, Mauriziano Umberto Hospital, Turin - Italy and Ricardo Asteggiano, Laboratorio Analisi Ricerca Clinica, Turin - Italy.

In this podcast, Tiziana Aranzulla joins Ricardo Asteggiano to discuss the management of women's heart health. REFERENCES:

1. Greenwood BN, Carnahan S, Huang L. Patient-physician gender concordance and increased mortality among female heart attack patients. Proc Natl Acad Sci USA. 2018 Aug 21;115(34):8569-74. https://www.pnas.org/doi/10.1073/pnas.1800097115
2. CardioDonna Project:

1. https://www.youtube.com/watch?v=V4dauT9OMUc
2. https://www.insalutenews.it/in-salute/medicina-di-genere-salvata-la-prima-paziente-al-centro-cardiodonna-del-mauriziano-di-torino

1. Noelle Russell: https://www.youtube.com/watch?v=4ZRdje_TZFo

With Eva Gerdts, University of Bergen, Bergen - Norway and Marc Ferrini, CH Saint Joseph and Saint Luc, Lyon - France. In this podcast, Eva Gerdts joins Marc Ferrini to discuss menopause and cardiovascular risk. REFERENCES:

1. Swan study: El Khoudary SR, Greendale G, Crawford SL, Avis NE, Brooks MM, Thurston RC, Karvonen-Gutierrez C, Waetjen LE, Matthews K. The menopause transition and women's health at midlife: a progress report from the Study of Women's Health Across the Nation (SWAN). Menopause. 2019;26:1213-27.
2. Joint analysis of four population cohorts in the USA: Ji H, Kim A, Ebinger JE, Niiranen TJ, Claggett BL, Bairey Merz CN, Cheng S. Sex Differences in Blood Pressure Trajectories Over the Life Course. JAMA Cardiol. 2020 Mar 1;5:19-26. Erratum in: JAMA Cardiol. 2020 Mar 1;5(3):364.
3. Women's Health Initiative
4. HERS study: Grady D, Applegate W, Bush T, Furberg C, Riggs B, Hulley SB. Heart and Estrogen/progestin Replacement Study (HERS): design, methods, and baseline characteristics. Control Clin Trials. 1998 Aug;19(4):314-35.

With William John McKenna, University College London, London - UK and Marc Ferrini, CH Saint Joseph and Saint Luc, Lyon - France. In this podcast, William John McKenna joins Marc Ferrini to discuss how to implement a diagnosis of hypertrophic cardiomyopathy in 2026.

With Alex Horby Christensen, Copenhagen University Hospital - Rigshospitalet, Copenhagen - Denmark and Thomas Kumler, Herlev-Gentofte Hospital and Steno Diabetes Center, Herlev - Denmark.

In this podcast, Alex Horby Christensen joins Thomas Kumler to discuss the challenges of the treatment of hypertrophic cardiomyopathy in 2026.

With Konstantinos Toutouzas, National & Kapodistrian University of Athens - Greece and Stefano Nistri, CMSR Veneto Medica, Altavilla Vicentina - Italy.

In this podcast, Konstantinos Toutouzas joins Stefano Nistri to discuss the assessment of asymptomatic patients with aortic valve stenosis.

With Victoria Delgado, Germans Trias i Pujol Hospital, Barcelona - Spain and Stefano Nistri, CMSR Veneto Medica, Altavilla Vicentina - Italy. In this podcast, Victoria Delgado joins Stefano Nistri to discuss the management of heart failure in patients with aortic stenosis.

With Hector Bueno, Task Force Co-Chairperson of the "2025 ESC Clinical Consensus Statement on mental health and cardiovascular disease", National Centre for Cardiovascular Research (CNIC), Madrid - Spain and Ruxandra Christodorescu, CardioPractice Board member, University of Medicine and Pharmacy Victor Babes, Timisoara - Romania.

In this podcast, Hector Bueno joins Ruxandra Christodorescu to discuss sex and gender differences in mental health. Reference: Bueno H, Deaton C, Farrero M, Forsyth F, Braunschweig F, Buccheri S, Dragan S, Gevaert S, Held C, Kurpas D, Ladwig KH, Lionis CD, Maas AHEM, Merșa CO, Mindham R, Pedersen SS, Rojnic Kuzman M, Szmit S, Taylor RS, Uchmanowicz I, Vilchinsky N; ESC Scientific Document Group. 2025 ESC Clinical Consensus Statement on mental health and cardiovascular disease: developed under the auspices of the ESC Clinical Practice Guidelines Committee. Eur Heart J. 2025 Nov 3;46(41):4156-4225. doi: 10.1093/eurheartj/ehaf191.

With Marta Farrero, Task Force Coordinator of the "2025 ESC Clinical Consensus Statement on mental health and cardiovascular disease", Heart Failure and Transplant Unit, Hospital Clinic of Barcelona, Barcelona - Spain and Ruxandra Christodorescu, CardioPractice Board member, University of Medicine and Pharmacy Victor Babes, Timisoara - Romania.

In this podcast, Marta Farrero joins Ruxandra Christodorescu to discuss heart failure and mental health.

Reference: Bueno H, Deaton C, Farrero M, Forsyth F, Braunschweig F, Buccheri S, Dragan S, Gevaert S, Held C, Kurpas D, Ladwig KH, Lionis CD, Maas AHEM, Merșa CO, Mindham R, Pedersen SS, Rojnic Kuzman M, Szmit S, Taylor RS, Uchmanowicz I, Vilchinsky N; ESC Scientific Document Group. 2025 ESC Clinical Consensus Statement on mental health and cardiovascular disease: developed under the auspices of the ESC Clinical Practice Guidelines Committee. Eur Heart J. 2025 Nov 3;46(41):4156-4225. doi: 10.1093/eurheartj/ehaf191.

With Cecilia Linde, President-Elect of the ESC, Karolinska Institute, Stockholm - Sweden and Marc Ferrini, Editor-in-Chief CardioPractice, CH Saint Joseph and Saint Luc, Lyon - France.

In this podcast, Cecilia Linde joins Marc Ferrini to discuss general cardiology and cardiometabolic diseases.