Sila Bal, MD, MPH, welcomes Daniel S. Choi, MD, to discuss the case of a 65-year-old woman with Fuchs endothelial dystrophy who was interested in a corneal transplant. Dr. Choi outlines the surgical steps and indications for penetrating keratoplasty (PKP), Descemet stripping endothelial keratoplasty (DSEK), and Descemet membrane endothelial keratoplasty (DMEK). He also explains the potential postoperative complications one might experience following each procedure and reveals how he would approach this case. Drs. Bal and Choi also touch on newer developments for treating endothelial dystrophy such as Descemet stripping only (DSO).