In this episode, Ehsan Rahimy, MD, talks to Sila Bal, MD, MPH, about a case of a 13-year-old girl who presented with floaters and decreased visual acuity for 2 weeks. Examination revealed 1+ vitreous cells with a focal area of necrotizing chorioretinitis. Dr. Rahimy outlines his approach to this case and his framework for making a diagnosis. He then explains how to navigate treatment strategies for rare infectious etiologies in the retina.