Jordan Deaner, MD, vitreoretinal surgeon and uveitis specialist at Wills Eye Hospital, talks to Ogul Uner, MD, about white dot syndromes, a group of inflammatory chorioretinopathies. In the discussed case, a 35-year-old woman presented with photopsias in both eyes, and dilated examination showed 1+ vitreous cells and gray-white lesions in both eyes. Dr. Deaner explains what additional questions he would ask about this patient’s history and how he would start to build a differential diagnosis. Drs. Uner and Deaner further discuss the typical presentations of white dot syndromes, including acute posterior multifocal placoid pigment epitheliopathy (APMPPE), multiple evanescent white dot syndrome (MEWDS), and others.