Pastor Van sermon titled "Can We Trust the Bible?" addresses doubts about the Bible's reliability and emphasizes its significance in our lives. He discusses the history of the Bible's creation, the risks people took to share it, and references non-believers acknowledging its power. Pastor Van highlights the trustworthiness of the Bible through biblical references and encourages listeners to base their lives on its teachings. The sermon underscores the importance of living out biblical principles, applying Scripture in daily life, and ultimately finding a deeper relationship with Jesus through the Word.