It's the GameChangers' Birthday! This episode is a rapid review of a few subjects to celebrate the first year of GameChangers. From oral iron administration to the use of metronidazole with alcohol or serotonin syndrome, this episode has all the ingredients for a celebration!GameChangers' host, Geoff Wall, just released new music! Check out his latest EP here: https://open.spotify.com/artist/0J26ngHZz2cf6mQR3UiEHW?827= or wherever you listen to music!Reference: Stoffel NU, Cercamondi CI, Brittenham G, et al. Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials. Lancet Haematol. 2017 Nov;4(11):e524-e533. doi: 10.1016/S2352-3026(17)30182-5. Epub 2017 Oct 9. PMID: 29032957.Kaundal R, Bhatia P, Jain A, et al. Randomized controlled trial of twice-daily versus alternate-day oral iron therapy in the treatment of iron-deficiency anemia. Ann Hematol. 2020 Jan;99(1):57-63. doi: 10.1007/s00277-019-03871-z. Epub 2019 Dec 6. PMID: 31811360.Visapää JP, Tillonen JS, Kaihovaara PS, et al. Lack of disulfiram-like reaction with metronidazole and ethanol. Ann Pharmacother. 2002 Jun;36(6):971-4. doi: 10.1345/aph.1A066. PMID: 12022894.Orlova Y, Rizzoli P, Loder E. Association of Coprescription of Triptan Antimigraine Drugs and Selective Serotonin Reuptake Inhibitor or Selective Norepinephrine Reuptake Inhibitor Antidepressants With Serotonin Syndrome. JAMA Neurol. 2018 May 1;75(5):566-572. doi: 10.1001/jamaneurol.2017.5144. PMID: 29482205; PMCID: PMC5885255.CPE details for GameChangers Podcast April 2021Learning Objective: Discuss the evidence-based dosing of oral iron supplementation.0107-0000-21-158-H01-P0.2 CEU/2 Hrs (Knowledge)Initial Release Date: 04/06/21Expiration Date: 03/02/24Additional CPE information is located at https://www.ceimpact.com/podcast See omnystudio.com/listener for privacy information.

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Alzheimer's Disease and Related Dementias are a terrible disease on individuals, caregivers, and communities. There are no cures. However, new data has come out discussing the risk factors, polypharmacy, and a potential early detection opportunity. It's time to de-prescribe and follow the money.Reference: Nicholas LH, Langa KM, Bynum JPW, Hsu JW. Financial Presentation of Alzheimer Disease and Related Dementias. JAMA Intern Med. 2021;181(2):220–227. doi:10.1001/jamainternmed.2020.6432Maust DT, Strominger J, Kim HM, et al. Prevalence of Central Nervous System–Active Polypharmacy Among Older Adults With Dementia in the US. JAMA. 2021;325(10):952–961. doi:10.1001/jama.2021.1195CPE details for GameChangers Podcast April 2021Learning Objective: Discuss if adverse financial outcomes may be a risk factor for future dementia diagnosis.0107-0000-21-158-H01-P0.2 CEU/2 Hrs (Knowledge)Initial Release Date: 04/06/21Expiration Date: 03/02/24Additional CPE information is located at https://www.ceimpact.com/podcast Disclosure: Dr. Galdo is a member of the Board of Directors for the Alabama Chapter of the Alzheimer's Association.See omnystudio.com/listener for privacy information.

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More and more vaccines are getting authorization in the United States to prevent COVID-19. However, sometimes a vaccine trial is not always effective. But even failure can provide new insights. Learn about the Janssen COVID-19 vaccine and what happened with the recent Hepatitis C vaccine candidate.This podcast was recorded prior to the joint CDC and FDA statement on the Johnson & Johnson/Janssen COVID-19 vaccine on April 13th. On April 13th, 2021, the CDC and FDA issued a joint statement recommending a pause on the use of the Johnson & Johnson/Janssen COVID-19 vaccine until further notice. Click here for the full statement.Reference: Page K, Melia M, Veenhuis R, et al. Randomized Trial of a Vaccine Regimen to Prevent Chronic HCV Infection. N Engl J Med 2021; 384:541-549. DOI: 10.1056/NEJMoa2023345Fact Sheet for Healthcare Providers Administering Vaccine Emergency Use Authorization of the Janssen COVID-19 Vaccine to Prevent Coronavirus Disease 2019. https://www.fda.gov/media/146304/download CPE details for GameChangers Podcast April 2021Learning Objective: Describe the outcomes of a recently published trial on hepatitis C vaccine candidates.0107-0000-21-158-H01-P0.2 CEU/2 Hrs (Knowledge)Initial Release Date: 04/06/21Expiration Date: 03/02/24Additional CPE information is located at https://www.ceimpact.com/podcast See omnystudio.com/listener for privacy information.

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The battle against the COVID-19 pandemic has continued for over a year. The evidence continues to update and change, and more and more people are becoming vaccinated. This episode provides a review of the newest literature including guidance on vaccinated individuals. But, remember, don't stop wearing a mask now!Reference: Interim Public Health Recommendations for Fully Vaccinated People. Centers for Disease Control and Prevention. https://www.cdc.gov/coronavirus/2019-ncov/vaccines/fully-vaccinated-guidance.html.CPE details for GameChangers Podcast April 2021Learning Objective: Describe evidence-based recommendations to mitigate SARS-CoV-2 infections0107-0000-21-158-H01-P0.2 CEU/2 Hrs (Knowledge)Initial Release Date: 04/06/21Expiration Date: 03/02/24Additional CPE information is located at https://www.ceimpact.com/podcast See omnystudio.com/listener for privacy information.

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Recently the American Gastroenterological Society updated their guidelines for treatment for a true medical emergency: gastric and esophageal bleeding. This episode reviews the guidelines and highlights the importance of several changes to management. Today's episode is sponsored by a special CEimpact FREE Law focused webinar:Make sure to save your spot for FREE LIVE LAW CE April 1st. 7PM. https://ceimpact.com/law Reference: Henry Z, Patel K, Patton H, et al. AGA Clinical Practice Update on Management of Bleeding Gastric Varices: Expert Review. Clinical Gastroenterology and Hepatology. 2021. https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S154235652100077X?returnurl=null&referrer=null CPE details for GameChangers Podcast March 2021Learning Objective: Identify appropriate therapy for individuals with variceal bleeds based on the new guidelines0107-0000-21-097-H01-P0.25 CEU/2.5 Hrs (Knowledge)Initial Release Date: 03/02/21Expiration Date: 03/02/24Additional CPE information is located at https://www.ceimpact.com/podcast See omnystudio.com/listener for privacy information.

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Aspirgillosis is a deadly fungal infection that is a major cause of mortality in patients with impaired immune systems. The current standard of care has been voriconazole due to the favorable side effect profile compared to amphotericin. However, posaconazole may not have there adverse effects and be a reasonable course of therapy. Is voriconazole just just a phase?Today's episode is sponsored by a special CEimpact FREE Law focused webinar: Save your spot - FREE LIVE LAW CEwebinar on April 1st.  SPOTS ARE LIMITED!https://ceimpact.com/law Reference: Maertens JA, Rahav G, Lee DG, et al. Posaconazole versus voriconazole for primary treatment of invasive aspergillosis: a phase 3, randomised, controlled, non-inferiority trial. Lancet. 2021 Feb 6;397(10273):499-509. doi: 10.1016/S0140- 6736(21)00219-1. PMID: 33549194.Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America, Clinical Infectious Diseases, Volume 63, Issue 4, 15 August 2016, Pages e1–e60, hMps://doi.org/10.1093/cid/ciw326CPE details for GameChangers Podcast March 2021Learning Objective: Develop appropriate treatment of aspergillosis infections based on clinical studies.0107-0000-21-097-H01-P0.25 CEU/2.5 Hrs (Knowledge)Initial Release Date: 03/02/21Expiration Date: 03/02/24Additional CPE information is located at https://www.ceimpact.com/podcastSee omnystudio.com/listener for privacy information.

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The recently published STEP trial showed a dramatic effect on weight loss with the weekly injectable semaglutide versus placebo. Lay media picked up the headlines from this potential "GameChanger" medication for weight loss. With this one shot will patient lose themselves?Reference: Wilding J, Batterham R, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. February 10, 2021. DOI: 10.1056/NEJMoa2032183CPE details for GameChangers Podcast March 2021Learning Objective: Discuss the design of the STEP trial0107-0000-21-097-H01-P0.25 CEU/2.5 Hrs (Knowledge)Initial Release Date: 03/02/21Expiration Date: 03/02/24Additional CPE information is located at https://www.ceimpact.com/podcast See omnystudio.com/listener for privacy information.

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The endocannabinoid system is influenced by compounds found the Cannabis genus of plants and involves two compounds: cannabidiol (CBD) and tetrahydrocannabinol (THC). Federal and state regulation is changing, so the medicinal and recreatoinal use of cannabis-related prodcuts continues to increase. Although not life-threatening, some patients may experience Cannabis Hyperemesis Syndrome. Fortunately, a narrative review outlines the causes and treatment to help get out the weeds of treatment.Reference: Perisetti A, Gajendran M, Dasari C, et al. Cannabis hyperemesis syndrome: an update on the pathophysiology and management. Annals of Gastroenterology (2020) 33, 1-8. http://www.annalsgastro.gr/files/journals/1/earlyview/2020/ev-09-2020-01-AG_5230-0528.pdf CPE details for GameChangers Podcast March 2021Learning Objective: Describe the potential mechanisms and treatment options for Cannabis Hyperemesis Syndrome.0107-0000-21-097-H01-P0.25 CEU/2.5 Hrs (Knowledge)Initial Release Date: 03/02/21Expiration Date: 03/02/24Additional CPE information is located at https://www.ceimpact.com/podcast See omnystudio.com/listener for privacy information.

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The recently published (in a pre-print server) COLCORONA study, sponsored by the Montreal Heart institute and conducted in 6 countries aimed to show if using colchicine would decrease risk of hospitalization and death in outpatients with COVID-19. Will it work? How's the study design? Learn the facts.Reference: Tardif J, Bouabdallaoui N, L'Allier P, et al. Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19. Pre-Print. https://www.medrxiv.org/content/10.1101/2021.01.26.21250494v1CPE details for GameChangers Podcast March 2021Learning Objective: Apply the results of the CORCORONA study to patients with COVID-19 disease.0107-0000-21-097-H01-P0.25 CEU/2.5 Hrs (Knowledge)Initial Release Date: 03/02/21Expiration Date: 03/02/24Additional CPE information is located at https://www.ceimpact.com/podcast See omnystudio.com/listener for privacy information.

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