Heart failure is a serious condition that occurs when a damaged heart loses its ability to pump blood around the body. It affects as many as 100 million people worldwide and it is a progressive disease such that five years after a diagnosis, 50% of patients with heart failure will be dead.

The UK-based company Ceryx Medical has created a new bioelectronic device called Cysoni, which is designed to adjust the pace of the heart as a patient breathes in and out. This mimics a normal physiological process called respiratory sinus arrhythmia, which can be absent in people with heart failure. The company has just began the first trial of Cysoni on human subjects.

This podcast features the biomedical engineer Stuart Plant and the physicist Ashok Chauhan, who are Ceryx Medical’s CEO and senior scientist respectively. In a wide-ranging conversation with Physics World’s Margaret Harris, they talk about how bioelectronics could be used treat heart failure and some other diseases. Chauhan and Plant also chat about challenges and rewards of developing medical technologies within a small company.