This episode is hosted by Josie Baker, MS, LGC, and features Maegan Roberts, MS, LGC, a Genetic Counselor from the Ohio State University.

The in-depth discussions focus on CDH1 and hereditary diffuse gastric cancer, covering the history of discovery, evolving penetrance estimates, and updated risk insights. They explore differences between IGCLC’s more conservative European approach and NCCN’s U.S.-focused guidelines, offering practical advice on which to follow. The conversation highlights the challenges of genetic counseling, including how to approach discussions with honesty and confidence. Megan Roberts also shares her perspective from her work with the ClinGen CDH1 Variant Curation Expert Panel, IGCLC, and the Ohio State University CDH1-Associated BCDS Registry.

Do you have a patient with a CDH1 variant and clinical features consistent with BCDS? The Ohio State University CDH1-Associated BCDS Registry is actively recruiting participants. This research initiative aims to better understand cancer risks and phenotypic characteristics associated with CDH1-related Blepharocheilodontic Syndrome (BCDS). Learn more HERE.

This episode is hosted by Emma Keel, MS, CGC, and features Ying Liu, MD, MPH, a Gynecologic Medical Oncologist & Clinical Geneticist, Memorial Sloan Kettering Cancer Center, and Nicole D. Edison, MD, Clinical Associate of Obstetrics & Gynecology, University of Chicago.

The in-depth discussion focuses on managing gynecologic cancer risk in patients with Lynch syndrome, spotlighting the significant updates to the National Comprehensive Cancer Network (NCCN) guidelines released in September 2024 that have shifted the clinical approach for these patients. 

In partnership, the CGA-IGC Education and Research Committees are pleased to present a three-part podcast series focused on research collaborations.

Emma Keel, MS, CCG spoke with Melyssa Aronson, MSc, CGC and Lucie Stengs, BSc, from the International Replication Repair Deficiency Consortium (IRRDC). 

This episode is essential listening for clinicians, researchers, and anyone interested in hereditary GI cancer syndromes research. Learn about this consortium's evolution from a local registry to an international collaboration studying rare genetic disorders, particularly CMMRD. It provides insights about the progress in developing diagnostic tools, establishing a biobank, and conducting research on potential treatments, including immunotherapy and vaccines. Also the challenges of managing the growing consortium, emphasized the importance of patient advocacy and international collaboration. 

If you have any questions or are interested in joining the consortium please contact or Melyssa Aronson ([email protected]) or Lucie Stengs ([email protected]).

In partnership, the CGA-IGC Education and Research Committees are pleased to present the second episode of a three-part series focused on Research Collaborations.

This episode is hosted by Emma Keel, MS, CCG, who spoke with Ophir Gilad, MD, the lead of the Gastric CDH1 Multicenter Consortium.

This episode is essential listening for clinicians, researchers, and anyone interested in hereditary cancer syndromes. It showcases the power of collaboration and the potential for building successful research consortiums to advance our understanding of complex genetic conditions like CDH1-related gastric cancer.

In partnership, the CGA-IGC Education and Research Committees are pleased to present the first episode of a three-part series focused on Research Collaborations. 

This episode is hosted by Joshua Melson, MD, and features CGA-IGC past president Swati Patel, MD, MS, along with recipients of the CGA-IGC & CCARE Lynch Syndrome Research Award and CGA-IGC committee members, Holli Loomans-Kropp, PhD, MPH and Zachariah H. Foda, MD, PhD, all of whom are part of the LINEAGE consortium.
 
This episode is essential listening for clinicians, researchers, and anyone interested in hereditary GI cancer syndromes, as well as the future of precision medicine, genetic epidemiology, and patient-centered research. It also offers valuable insights and tips for those looking to establish a research consortium or collaborative, emphasizing the importance of a solid governance structure, data use agreements, and the need to involve your institution's legal departments early in the process.

Este episodio está copresentado por Joshua Sommovilla, MD, y Thomas (T.J.) Slavin, MD, FACMGG, DABCC, y cuenta con la participación de Pål Møller, MD, PhD, científico principal del Hospital Universitario de Oslo (Noruega).

Juntos profundizan en el artículo del Dr. Møller «Incidencias de adenomas colorrectales y cánceres bajo vigilancia colonoscópica sugieren una vía acelerada “Big Bang” hacia el CCR en tres de los cuatro Síndromes de Lynch» (in English).

Lea la entrada de nuestro blog (in English) para saber más sobre este podcast AQUÍ

This episode is co-hosted by Joshua Sommovilla, MD and Thomas (T.J.) Slavin, MD, FACMGG, DABCC and features Pål Møller, MD, PhD, a Senior Scientist at the Oslo University Hospital, Norway

Together they delve into the Dr Møller's paper "Incidences of colorectal adenomas and cancers under colonoscopy surveillance suggest an accelerated "Big Bang" pathway to CRC in three of the four Lynch Syndromes."

Read our blog post to learn more about this podcast HERE

En colaboración con LA-GETH, este podcast, en el que participan Karin Álvarez Valenzuela, PhD, de Chile, y Adriana Della Valle, MD, de Uruguay. 

El podcast titulado "Acceso a la Atención Genética en Comunidades Diversas: La Experiencia Latinoamericana" explora los desafíos únicos y perspectivas relacionadas con el acceso a las pruebas genéticas en poblaciones diversas de América Latina. Los expertos discuten la importancia de enfoques adaptados culturalmente para las pruebas genéticas y el potencial para abordar las disparidades en el sistema de salud. Además, este podcast destaca la investigación en curso y la necesidad de datos inclusivos para servir mejor a las poblaciones diversas en América Latina.

In collaboration with LA-GETH, this podcast titled " Access to Genetic Care in Diverse Communities: The Latin American Experience" features Karin Álvarez Valenzuela, PhD from Chile, and Adriana Della Valle, MD, from Uruguay, and explores the unique challenges and insights surrounding genetic testing in diverse Latin American populations.  

Experts discuss the importance of culturally tailored approaches to genetic testing and the potential for addressing health disparities. Furthermore, this podcast also highlights ongoing research and the need for inclusive data to better serve diverse populations in Latin America.

This new podcast series, initiated by the CGA-IGC Research Committee in 2023, highlights the work of previous CGA-IGC Research Grant recipients.

The second episode is hosted by Catie Neumann, MS., LCGC, a Cancer Genetic Counselor at Fox Chase Cancer Center, and features the 2022 grant recipient, Giovana Torrezan, PhD, an associate researcher at A.C. Camargo Cancer Center in Sao Paulo, Brazil.

The podcast transcript is available here.