There is a good chance you have a bottle somewhere in the house, a better than even chance it says five or ten milligrams, and an almost certain chance nobody ever told you when to take it. That last part turns out to matter more than the amount.
Melatonin is not a sedative — it is a signal about timing, which means it behaves like two different drugs depending on when you send it. We go through what the dose-response trials actually show (the benefit climbs to around four milligrams, which is not the advice you usually hear), the much smaller dose that shifts your body clock instead, and the 2017 analysis that measured what is really inside the bottle: content ranging from eighty-three percent below the label to four hundred and seventy-eight percent above it.
SOURCES:
Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug — systematic review and dose-response meta-analysis, Journal of Pineal Research, 2024
Low-dose melatonin timed to dim light melatonin onset in delayed sleep-wake phase disorder — Journal of Clinical Sleep Medicine
Erland & Saxena — Melatonin Natural Health Products and Supplements, Journal of Clinical Sleep Medicine, 2017;13(2):275
Written and fact-checked by Brent Burgess. Narration uses a synthetic voice model of his own voice.
This episode is general education and is not medical advice. Sleep problems can have serious underlying causes — talk to your doctor before changing medication, supplements, or treatment.